Synthesis, Characterization, Liquid Crystalline and Antibacterial Properties of Pyrimidine Derivatives

Pyrimidine and its derivatives are commonly synthesized due to their reactive and rigid which employ in many applications such as liquid crystal and biological properties. A series of pyrimidine derivatives bearing alkyl chain (50a-c, 53a-c) and halogen 56a-f substituents has been successfully synth...

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Main Author:	Tasya Ezzati, Binti Busrah @ Affendi
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://ir.unimas.my/id/eprint/21159/1/Tasya.pdf
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id	my-unimas-ir.21159
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spelling	my-unimas-ir.211592023-08-23T06:26:22Z Synthesis, Characterization, Liquid Crystalline and Antibacterial Properties of Pyrimidine Derivatives 2017 Tasya Ezzati, Binti Busrah @ Affendi Q Science (General) QD Chemistry Pyrimidine and its derivatives are commonly synthesized due to their reactive and rigid which employ in many applications such as liquid crystal and biological properties. A series of pyrimidine derivatives bearing alkyl chain (50a-c, 53a-c) and halogen 56a-f substituents has been successfully synthesized via nucleophilic reaction with 17-78% yield. The alkylated (49a-c, 52a-c) and halogenated (55a-f) chalcone were earlier prepared via Claisen Schmidt condensation prior to the synthesis of pyrimidine. The successfully synthesized pyrimidine derivatives were illustrated in the FTIR and 13C NMR spectra whereby the presence of absorptions and resonances attributed to C=S and C-N group while 1H NMR showed resonances of singlet for N-H group. The DSC thermogram showed thermotropic liquid crystal properties of pyrimidine 53a-b gave direct transition from Cr-I phase while 53c exhibited Cr-Cr and Cr-I transition. Antibacterial studies against bacteria Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) of pyrimidine derivatives bearing alkyl group (53a-c) however not exhibit antibacterial activities towards both bacteria. unimas 2017 Thesis http://ir.unimas.my/id/eprint/21159/ http://ir.unimas.my/id/eprint/21159/1/Tasya.pdf text en validuser masters UNIMAS
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Tasya Ezzati, Binti Busrah @ Affendi Synthesis, Characterization, Liquid Crystalline and Antibacterial Properties of Pyrimidine Derivatives
description	Pyrimidine and its derivatives are commonly synthesized due to their reactive and rigid which employ in many applications such as liquid crystal and biological properties. A series of pyrimidine derivatives bearing alkyl chain (50a-c, 53a-c) and halogen 56a-f substituents has been successfully synthesized via nucleophilic reaction with 17-78% yield. The alkylated (49a-c, 52a-c) and halogenated (55a-f) chalcone were earlier prepared via Claisen Schmidt condensation prior to the synthesis of pyrimidine. The successfully synthesized pyrimidine derivatives were illustrated in the FTIR and 13C NMR spectra whereby the presence of absorptions and resonances attributed to C=S and C-N group while 1H NMR showed resonances of singlet for N-H group. The DSC thermogram showed thermotropic liquid crystal properties of pyrimidine 53a-b gave direct transition from Cr-I phase while 53c exhibited Cr-Cr and Cr-I transition. Antibacterial studies against bacteria Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) of pyrimidine derivatives bearing alkyl group (53a-c) however not exhibit antibacterial activities towards both bacteria.
format	Thesis
qualification_level	Master's degree
author	Tasya Ezzati, Binti Busrah @ Affendi
author_facet	Tasya Ezzati, Binti Busrah @ Affendi
author_sort	Tasya Ezzati, Binti Busrah @ Affendi
title	Synthesis, Characterization, Liquid Crystalline and Antibacterial Properties of Pyrimidine Derivatives
title_short	Synthesis, Characterization, Liquid Crystalline and Antibacterial Properties of Pyrimidine Derivatives
title_full	Synthesis, Characterization, Liquid Crystalline and Antibacterial Properties of Pyrimidine Derivatives
title_fullStr	Synthesis, Characterization, Liquid Crystalline and Antibacterial Properties of Pyrimidine Derivatives
title_full_unstemmed	Synthesis, Characterization, Liquid Crystalline and Antibacterial Properties of Pyrimidine Derivatives
title_sort	synthesis, characterization, liquid crystalline and antibacterial properties of pyrimidine derivatives
granting_institution	UNIMAS
publishDate	2017
url	http://ir.unimas.my/id/eprint/21159/1/Tasya.pdf
_version_	1783728227133423616

Synthesis, Characterization, Liquid Crystalline and Antibacterial Properties of Pyrimidine Derivatives

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