Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance

Chloroquine (CQ) resistant P. falciparum was first reported in the 1960s at the Thai-Cambodia border. Gradually CQ resistance has spread and is found in all regions where P. falciparum transmission occurs. The emergence of CQ resistance due to excessive CQ selection pressure on the parasite populati...

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主要作者:	Lau, Hui Chong
格式:	Thesis
語言:	English
出版:	2008
主題:	R Medicine (General) RB Pathology
在線閱讀:	http://ir.unimas.my/id/eprint/23/8/Molecular%20characterisation%20of%20the%20plasmodium%20falciparum%20pfcrt%20gene%20involved%20in%20chloroquine%20resistance.pdf
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id	my-unimas-ir.23
record_format	uketd_dc
spelling	my-unimas-ir.232023-03-07T07:30:30Z Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance 2008 Lau, Hui Chong R Medicine (General) RB Pathology Chloroquine (CQ) resistant P. falciparum was first reported in the 1960s at the Thai-Cambodia border. Gradually CQ resistance has spread and is found in all regions where P. falciparum transmission occurs. The emergence of CQ resistance due to excessive CQ selection pressure on the parasite populations has become an important issue because of the higher mortality and morbidity associated with drug resistance. Currently CQ is no longer recommended to treat falciparum malaria. CQ resistance in P. falciparum has been attributed to a single amino acid substitution on the P. falciparum chloroquine resistant transporter (pfcrt) at position 76 where Iysine is substituted with threonine (K76T). Molecular studies showed that CQ resistance emerged independently at five different geographical locations namely: Southeast Asia, two sites in South America, Papua New Guinea and the Philippines. Further analysis of resistant isolates revealed 22 additional non-silent amino acid substitutions on the pfcrt gene with a new amino acid substitution detected in the study reported here. Universiti Malaysia Sarawak, (UNIMAS) 2008 Thesis http://ir.unimas.my/id/eprint/23/ http://ir.unimas.my/id/eprint/23/8/Molecular%20characterisation%20of%20the%20plasmodium%20falciparum%20pfcrt%20gene%20involved%20in%20chloroquine%20resistance.pdf text en validuser masters Universiti Malaysia Sarawak Faculti of Medicine and Human Science
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Lau, Hui Chong Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
description	Chloroquine (CQ) resistant P. falciparum was first reported in the 1960s at the Thai-Cambodia border. Gradually CQ resistance has spread and is found in all regions where P. falciparum transmission occurs. The emergence of CQ resistance due to excessive CQ selection pressure on the parasite populations has become an important issue because of the higher mortality and morbidity associated with drug resistance. Currently CQ is no longer recommended to treat falciparum malaria. CQ resistance in P. falciparum has been attributed to a single amino acid substitution on the P. falciparum chloroquine resistant transporter (pfcrt) at position 76 where Iysine is substituted with threonine (K76T). Molecular studies showed that CQ resistance emerged independently at five different geographical locations namely: Southeast Asia, two sites in South America, Papua New Guinea and the Philippines. Further analysis of resistant isolates revealed 22 additional non-silent amino acid substitutions on the pfcrt gene with a new amino acid substitution detected in the study reported here.
format	Thesis
qualification_level	Master's degree
author	Lau, Hui Chong
author_facet	Lau, Hui Chong
author_sort	Lau, Hui Chong
title	Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_short	Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_full	Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_fullStr	Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_full_unstemmed	Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
title_sort	molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance
granting_institution	Universiti Malaysia Sarawak
granting_department	Faculti of Medicine and Human Science
publishDate	2008
url	http://ir.unimas.my/id/eprint/23/8/Molecular%20characterisation%20of%20the%20plasmodium%20falciparum%20pfcrt%20gene%20involved%20in%20chloroquine%20resistance.pdf
_version_	1783727872937033728

Molecular characterisation of the plasmodium falciparum pfcrt gene involved in chloroquine resistance

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