Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones

This thesis describes the coordination chemistry of organotin(IV) with hydrazone and thiosemicarbarzone ligands. A comprehensive survey of the literature, focusing on works most pertinent and complementary to the synthesis, chemical reactivities, structures of organotin(IV) complexes and biological...

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Main Author:	Liew, Yew Zion.
Format:	Thesis
Language:	English
Published:	2008
Subjects:	QD Chemistry
Online Access:	http://ir.unimas.my/id/eprint/28959/2/Liew%20Yew%20Zion.pdf
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spelling	my-unimas-ir.289592023-03-07T08:03:52Z Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones 2008 Liew, Yew Zion. QD Chemistry This thesis describes the coordination chemistry of organotin(IV) with hydrazone and thiosemicarbarzone ligands. A comprehensive survey of the literature, focusing on works most pertinent and complementary to the synthesis, chemical reactivities, structures of organotin(IV) complexes and biological studies containing ONN, ONO, and ONS-donor is described extensively. New chelating hydrazone and thiosemicarbazone ligands, namely carbohydrazone bis(salicylaldehyde) [H4CBS] (1), pyruvic acid isonicotinoyl hydrazone [~PAI] (8), 2-hydroxyacetophenone thiosemicarbazone [H4APT] (14) and 3-hydroxy-2 butanone thiosemicarbazone [H4BT] (15) have been synthesized and characterized. In general, an interesting series of new organotin(IV) complexes has been synthesized by the direct reaction of RnSnC14-n (R = Me, Bu, Ph; n = 1, 2) with these hydrazone/thiosemicarbazone ligands (1, 8, 14 & 15) in the presence of base and refluxing in 1:2:1 mole ratio (metal:base:ligand) under Schlenk Vacuum line technique. Universiti Malaysia Sarawak (UNIMAS) 2008 Thesis http://ir.unimas.my/id/eprint/28959/ http://ir.unimas.my/id/eprint/28959/2/Liew%20Yew%20Zion.pdf text en validuser masters Universiti Malaysia Sarawak (UNIMAS) Faculty of Resource Science and Technology
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Liew, Yew Zion. Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones
description	This thesis describes the coordination chemistry of organotin(IV) with hydrazone and thiosemicarbarzone ligands. A comprehensive survey of the literature, focusing on works most pertinent and complementary to the synthesis, chemical reactivities, structures of organotin(IV) complexes and biological studies containing ONN, ONO, and ONS-donor is described extensively. New chelating hydrazone and thiosemicarbazone ligands, namely carbohydrazone bis(salicylaldehyde) [H4CBS] (1), pyruvic acid isonicotinoyl hydrazone [~PAI] (8), 2-hydroxyacetophenone thiosemicarbazone [H4APT] (14) and 3-hydroxy-2 butanone thiosemicarbazone [H4BT] (15) have been synthesized and characterized. In general, an interesting series of new organotin(IV) complexes has been synthesized by the direct reaction of RnSnC14-n (R = Me, Bu, Ph; n = 1, 2) with these hydrazone/thiosemicarbazone ligands (1, 8, 14 & 15) in the presence of base and refluxing in 1:2:1 mole ratio (metal:base:ligand) under Schlenk Vacuum line technique.
format	Thesis
qualification_level	Master's degree
author	Liew, Yew Zion.
author_facet	Liew, Yew Zion.
author_sort	Liew, Yew Zion.
title	Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones
title_short	Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones
title_full	Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones
title_fullStr	Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones
title_full_unstemmed	Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones
title_sort	synthesis, characterization and toxicity study of novel organotin (iv) complexes with hydrazone / thiosemicarbazones
granting_institution	Universiti Malaysia Sarawak (UNIMAS)
granting_department	Faculty of Resource Science and Technology
publishDate	2008
url	http://ir.unimas.my/id/eprint/28959/2/Liew%20Yew%20Zion.pdf
_version_	1783728365785579520

Synthesis, characterization and toxicity study of novel organotin (IV) complexes with hydrazone / Thiosemicarbazones

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