Ecotoxicity Assessment of Zinc Oxide Nanoparticles in Embryo Stages of Zebrafish (Danio rerio)

High demand of nanonmaterials have produced enormous applications in global industries. However, due to their extensive productions, release of different size of zinc oxide nanoparticles (ZnO NPs) into the environment has raised concerns in which the environment might pose ecotoxicological risk to t...

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Main Author:	Nuraqeelah, Binti Mohammad Shamhari
Format:	Thesis
Language:	English
Published:	2020
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://ir.unimas.my/id/eprint/29026/3/Ecotoxicity%20Assessment%20of%20Zinc%20Oxide%20Nanoparticles%20in%20Embryo%20Stages%20of.pdf
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spelling	my-unimas-ir.290262023-04-18T03:17:57Z Ecotoxicity Assessment of Zinc Oxide Nanoparticles in Embryo Stages of Zebrafish (Danio rerio) 2020 Nuraqeelah, Binti Mohammad Shamhari Q Science (General) QD Chemistry High demand of nanonmaterials have produced enormous applications in global industries. However, due to their extensive productions, release of different size of zinc oxide nanoparticles (ZnO NPs) into the environment has raised concerns in which the environment might pose ecotoxicological risk to the aquatic organisms. Presence of natural organic matter (NOM) mainly humic acid (HA) has also gain interest. As HA affect behavior of ZnO NPs which eventually affect the level of toxicity of ZnO NPs. Thus, this study was carried out in order to determine the toxicity level of different size (7.4 nm, 36 nm, and 73 nm) of ZnO NPs with different concentrations (1, 5, 10, 30, 50, and 100 mg/L) in embryonic zebrafish (5 hpf -96 hpf) with and without the presence of HA. This study was also carried out to investigate the behaviour of ZnO NPs in embryo water in terms of aggregation and dissolution. Findings showed that smaller ZnO NPs (7.4 nm) has a higher toxicity than larger NPs (36 nm and 73 nm) in which low survival rate was observed in embryo exposed to smaller ZnO NPs with 0% hatching rate. However, the presence of HA has greatly alleviated the toxicity of three sizes of ZnO NPs as more than 50 % of the survival rates as well as the hatching rates of embryonic zebrafish were observed. Other than that, dissolution and aggregation were found to be one of the most important role that contribute to toxicity. Finding demonstrated that smaller ZnO NPs has high dissolution as compared to larger ZnO NPs in which aggregation has occurred. The presence of HA has surprisingly increased the dissolution of ZnO NPs and stabilized the ZnO NPs in water. Therefore, presence of HA did influence the toxicity and the fate of ZnO NPs in the environment regardless of their particle sizes. Universiti Malaysia Sarawak (UNIMAS) 2020 Thesis http://ir.unimas.my/id/eprint/29026/ http://ir.unimas.my/id/eprint/29026/3/Ecotoxicity%20Assessment%20of%20Zinc%20Oxide%20Nanoparticles%20in%20Embryo%20Stages%20of.pdf text en validuser masters University Malaysia Sarawak, UNIMAS Faculty of Resource Science and Technology
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Nuraqeelah, Binti Mohammad Shamhari Ecotoxicity Assessment of Zinc Oxide Nanoparticles in Embryo Stages of Zebrafish (Danio rerio)
description	High demand of nanonmaterials have produced enormous applications in global industries. However, due to their extensive productions, release of different size of zinc oxide nanoparticles (ZnO NPs) into the environment has raised concerns in which the environment might pose ecotoxicological risk to the aquatic organisms. Presence of natural organic matter (NOM) mainly humic acid (HA) has also gain interest. As HA affect behavior of ZnO NPs which eventually affect the level of toxicity of ZnO NPs. Thus, this study was carried out in order to determine the toxicity level of different size (7.4 nm, 36 nm, and 73 nm) of ZnO NPs with different concentrations (1, 5, 10, 30, 50, and 100 mg/L) in embryonic zebrafish (5 hpf -96 hpf) with and without the presence of HA. This study was also carried out to investigate the behaviour of ZnO NPs in embryo water in terms of aggregation and dissolution. Findings showed that smaller ZnO NPs (7.4 nm) has a higher toxicity than larger NPs (36 nm and 73 nm) in which low survival rate was observed in embryo exposed to smaller ZnO NPs with 0% hatching rate. However, the presence of HA has greatly alleviated the toxicity of three sizes of ZnO NPs as more than 50 % of the survival rates as well as the hatching rates of embryonic zebrafish were observed. Other than that, dissolution and aggregation were found to be one of the most important role that contribute to toxicity. Finding demonstrated that smaller ZnO NPs has high dissolution as compared to larger ZnO NPs in which aggregation has occurred. The presence of HA has surprisingly increased the dissolution of ZnO NPs and stabilized the ZnO NPs in water. Therefore, presence of HA did influence the toxicity and the fate of ZnO NPs in the environment regardless of their particle sizes.
format	Thesis
qualification_level	Master's degree
author	Nuraqeelah, Binti Mohammad Shamhari
author_facet	Nuraqeelah, Binti Mohammad Shamhari
author_sort	Nuraqeelah, Binti Mohammad Shamhari
title	Ecotoxicity Assessment of Zinc Oxide Nanoparticles in Embryo Stages of Zebrafish (Danio rerio)
title_short	Ecotoxicity Assessment of Zinc Oxide Nanoparticles in Embryo Stages of Zebrafish (Danio rerio)
title_full	Ecotoxicity Assessment of Zinc Oxide Nanoparticles in Embryo Stages of Zebrafish (Danio rerio)
title_fullStr	Ecotoxicity Assessment of Zinc Oxide Nanoparticles in Embryo Stages of Zebrafish (Danio rerio)
title_full_unstemmed	Ecotoxicity Assessment of Zinc Oxide Nanoparticles in Embryo Stages of Zebrafish (Danio rerio)
title_sort	ecotoxicity assessment of zinc oxide nanoparticles in embryo stages of zebrafish (danio rerio)
granting_institution	University Malaysia Sarawak, UNIMAS
granting_department	Faculty of Resource Science and Technology
publishDate	2020
url	http://ir.unimas.my/id/eprint/29026/3/Ecotoxicity%20Assessment%20of%20Zinc%20Oxide%20Nanoparticles%20in%20Embryo%20Stages%20of.pdf
_version_	1783728367941451776

Ecotoxicity Assessment of Zinc Oxide Nanoparticles in Embryo Stages of Zebrafish (Danio rerio)

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