The Fabrication of Sago (Metroxylon sagu) Starch/ Poly (vinyl alcohol) (PVA)/ Carboxymethyl cellulose (CMC) Nanofibers for Drug Delivery Application

This study reported the fabrication of starch-based nanofibers derived from various weight ratios (w:w) of native sago starch (SS), poly (vinyl alcohol) (PVA) and carboxymethyl cellulose (CMC) using the electrospinning technique. The effects of electrospinning operation parameters on the surface mor...

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Main Author:	Khairool Azhar, Tuah
Format:	Thesis
Language:	English
Published:	2021
Subjects:	QD Chemistry
Online Access:	http://ir.unimas.my/id/eprint/36625/5/Khairool%20Azhar%20Bin%20Tuah.pdf
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id	my-unimas-ir.36625
record_format	uketd_dc
spelling	my-unimas-ir.366252023-05-29T04:33:00Z The Fabrication of Sago (Metroxylon sagu) Starch/ Poly (vinyl alcohol) (PVA)/ Carboxymethyl cellulose (CMC) Nanofibers for Drug Delivery Application 2021-12-17 Khairool Azhar, Tuah QD Chemistry This study reported the fabrication of starch-based nanofibers derived from various weight ratios (w:w) of native sago starch (SS), poly (vinyl alcohol) (PVA) and carboxymethyl cellulose (CMC) using the electrospinning technique. The effects of electrospinning operation parameters on the surface morphology of SS/PVA and SS/PVA/CMC nanofibers were observed by using Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FT-IR) Spectroscopy. The smooth and bead-free SS/PVA nanofibers with fibers diameters within the range of 90 nm to 150 nm were produced under the optimized conditions. The paracetamol (PCM) was encapsulated into both SS/PVA and SS/PVA/CMC nanofibers via the blending process. The SS/PVA nanofibers exhibited a maximum PCM loading capacity of 0.96 mg.mg-1 while, SS/PVA/CMC showed only 0.61 mg.mg-1 of SS/PVA/CMC. PCM was observed to release out from SS/PVA and SS/PVA/CMC nanofibers slowly and steadily for 72 hours. Finally, drug release mechanism shows the result for both SS/PVA and SS/PVA/CMC nanofibers more to First Order rather than Zero Order and belong to non-Fickian transport in within (0.43<n<0.85). Universiti Malaysia Sarawak (UNIMAS) 2021-12 Thesis http://ir.unimas.my/id/eprint/36625/ http://ir.unimas.my/id/eprint/36625/5/Khairool%20Azhar%20Bin%20Tuah.pdf text en validuser masters Universiti Malaysia Sarawak Faculty of Resource Science and Technology
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Khairool Azhar, Tuah The Fabrication of Sago (Metroxylon sagu) Starch/ Poly (vinyl alcohol) (PVA)/ Carboxymethyl cellulose (CMC) Nanofibers for Drug Delivery Application
description	This study reported the fabrication of starch-based nanofibers derived from various weight ratios (w:w) of native sago starch (SS), poly (vinyl alcohol) (PVA) and carboxymethyl cellulose (CMC) using the electrospinning technique. The effects of electrospinning operation parameters on the surface morphology of SS/PVA and SS/PVA/CMC nanofibers were observed by using Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FT-IR) Spectroscopy. The smooth and bead-free SS/PVA nanofibers with fibers diameters within the range of 90 nm to 150 nm were produced under the optimized conditions. The paracetamol (PCM) was encapsulated into both SS/PVA and SS/PVA/CMC nanofibers via the blending process. The SS/PVA nanofibers exhibited a maximum PCM loading capacity of 0.96 mg.mg-1 while, SS/PVA/CMC showed only 0.61 mg.mg-1 of SS/PVA/CMC. PCM was observed to release out from SS/PVA and SS/PVA/CMC nanofibers slowly and steadily for 72 hours. Finally, drug release mechanism shows the result for both SS/PVA and SS/PVA/CMC nanofibers more to First Order rather than Zero Order and belong to non-Fickian transport in within (0.43<n<0.85).
format	Thesis
qualification_level	Master's degree
author	Khairool Azhar, Tuah
author_facet	Khairool Azhar, Tuah
author_sort	Khairool Azhar, Tuah
title	The Fabrication of Sago (Metroxylon sagu) Starch/ Poly (vinyl alcohol) (PVA)/ Carboxymethyl cellulose (CMC) Nanofibers for Drug Delivery Application
title_short	The Fabrication of Sago (Metroxylon sagu) Starch/ Poly (vinyl alcohol) (PVA)/ Carboxymethyl cellulose (CMC) Nanofibers for Drug Delivery Application
title_full	The Fabrication of Sago (Metroxylon sagu) Starch/ Poly (vinyl alcohol) (PVA)/ Carboxymethyl cellulose (CMC) Nanofibers for Drug Delivery Application
title_fullStr	The Fabrication of Sago (Metroxylon sagu) Starch/ Poly (vinyl alcohol) (PVA)/ Carboxymethyl cellulose (CMC) Nanofibers for Drug Delivery Application
title_full_unstemmed	The Fabrication of Sago (Metroxylon sagu) Starch/ Poly (vinyl alcohol) (PVA)/ Carboxymethyl cellulose (CMC) Nanofibers for Drug Delivery Application
title_sort	fabrication of sago (metroxylon sagu) starch/ poly (vinyl alcohol) (pva)/ carboxymethyl cellulose (cmc) nanofibers for drug delivery application
granting_institution	Universiti Malaysia Sarawak
granting_department	Faculty of Resource Science and Technology
publishDate	2021
url	http://ir.unimas.my/id/eprint/36625/5/Khairool%20Azhar%20Bin%20Tuah.pdf
_version_	1783728478331338752

The Fabrication of Sago (Metroxylon sagu) Starch/ Poly (vinyl alcohol) (PVA)/ Carboxymethyl cellulose (CMC) Nanofibers for Drug Delivery Application

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