Curcumin Loaded Amino-Starch Nanoparticles as a Controlled Release Antimicrobial Agent

Native starch is well known to be cheap, non-toxic, renewable, and biodegradable biopolymer. In Malaysia, starch industries had been one of the important revenues, comprising native sago starch trading that are well established. Therefore, apart from being as a choice of staple food, starch could al...

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Main Author:	Lionel Victor, Kemin
Format:	Thesis
Language:	English
Published:	2021
Subjects:	Q Science (General) QD Chemistry TP Chemical technology
Online Access:	http://ir.unimas.my/id/eprint/37105/1/Lionel.pdf
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spelling	my-unimas-ir.371052023-06-23T03:11:42Z Curcumin Loaded Amino-Starch Nanoparticles as a Controlled Release Antimicrobial Agent 2021 Lionel Victor, Kemin Q Science (General) QD Chemistry TP Chemical technology Native starch is well known to be cheap, non-toxic, renewable, and biodegradable biopolymer. In Malaysia, starch industries had been one of the important revenues, comprising native sago starch trading that are well established. Therefore, apart from being as a choice of staple food, starch could also potentially be utilized as an alternative source of materials. In accordance with that, increase in human population had cause depletion of unrenewable natural resources which made mankind turning their focuses on alternative resource such as starch. In recent years, biomedical industries also in need of versatile material which could be easily moulded according to the desired applications. This make native starch as a suitable candidate in being an alternative material that suited biomedical field. However, despite being highly feasible, native starch lacked in its functionalities, which require proper modification and fabrication before it is suitable to be utilized. Therefore, in this study sago starch was modified by etherification and then fabricated by nanoprecipitation process, which formed amino-starch nanoparticles with particles size of 163 nm. Potential application of the prepared nanoparticles as controlled release nanocarrier of curcumin then were evaluated. Enhanced curcumin loading capacity of 0.76 mg.mg-1, as well as slow release of the turmeric derivatives over a period of 12 h were observed. The prepared nanomaterial was further tested for its antimicrobial properties. When tested against bacterial strain the curcumin loaded amino-starch nanoparticles showed inhibiting properties on both gram-negative (Salmonella typhimurium, Escherichia coli) and gram-positive bacteria (methicillin resistant Staphylococcus aureus). Antifungal study also exhibits supressing action of the loaded nanoparticles when tested against fungal strain of Aspergillus niger and Aspergillus flavus. In short, not only the functionality of the modified starch improved, the prepared amino-starch nanoparticles also showed high potential as a controlled release nanocarrier of curcumin and concurrently exhibit antimicrobial properties. Universiti Malaysia Sarawak (UNIMAS) 2021 Thesis http://ir.unimas.my/id/eprint/37105/ http://ir.unimas.my/id/eprint/37105/1/Lionel.pdf text en validuser masters Universiti Malaysia Sarawak Faculty of Resource Science and Technology
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	Q Science (General) QD Chemistry TP Chemical technology
spellingShingle	Q Science (General) QD Chemistry TP Chemical technology Lionel Victor, Kemin Curcumin Loaded Amino-Starch Nanoparticles as a Controlled Release Antimicrobial Agent
description	Native starch is well known to be cheap, non-toxic, renewable, and biodegradable biopolymer. In Malaysia, starch industries had been one of the important revenues, comprising native sago starch trading that are well established. Therefore, apart from being as a choice of staple food, starch could also potentially be utilized as an alternative source of materials. In accordance with that, increase in human population had cause depletion of unrenewable natural resources which made mankind turning their focuses on alternative resource such as starch. In recent years, biomedical industries also in need of versatile material which could be easily moulded according to the desired applications. This make native starch as a suitable candidate in being an alternative material that suited biomedical field. However, despite being highly feasible, native starch lacked in its functionalities, which require proper modification and fabrication before it is suitable to be utilized. Therefore, in this study sago starch was modified by etherification and then fabricated by nanoprecipitation process, which formed amino-starch nanoparticles with particles size of 163 nm. Potential application of the prepared nanoparticles as controlled release nanocarrier of curcumin then were evaluated. Enhanced curcumin loading capacity of 0.76 mg.mg-1, as well as slow release of the turmeric derivatives over a period of 12 h were observed. The prepared nanomaterial was further tested for its antimicrobial properties. When tested against bacterial strain the curcumin loaded amino-starch nanoparticles showed inhibiting properties on both gram-negative (Salmonella typhimurium, Escherichia coli) and gram-positive bacteria (methicillin resistant Staphylococcus aureus). Antifungal study also exhibits supressing action of the loaded nanoparticles when tested against fungal strain of Aspergillus niger and Aspergillus flavus. In short, not only the functionality of the modified starch improved, the prepared amino-starch nanoparticles also showed high potential as a controlled release nanocarrier of curcumin and concurrently exhibit antimicrobial properties.
format	Thesis
qualification_level	Master's degree
author	Lionel Victor, Kemin
author_facet	Lionel Victor, Kemin
author_sort	Lionel Victor, Kemin
title	Curcumin Loaded Amino-Starch Nanoparticles as a Controlled Release Antimicrobial Agent
title_short	Curcumin Loaded Amino-Starch Nanoparticles as a Controlled Release Antimicrobial Agent
title_full	Curcumin Loaded Amino-Starch Nanoparticles as a Controlled Release Antimicrobial Agent
title_fullStr	Curcumin Loaded Amino-Starch Nanoparticles as a Controlled Release Antimicrobial Agent
title_full_unstemmed	Curcumin Loaded Amino-Starch Nanoparticles as a Controlled Release Antimicrobial Agent
title_sort	curcumin loaded amino-starch nanoparticles as a controlled release antimicrobial agent
granting_institution	Universiti Malaysia Sarawak
granting_department	Faculty of Resource Science and Technology
publishDate	2021
url	http://ir.unimas.my/id/eprint/37105/1/Lionel.pdf
_version_	1783728482736406528

Curcumin Loaded Amino-Starch Nanoparticles as a Controlled Release Antimicrobial Agent

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