Synthesis and Characterization of Amine-Modified Starch Nanoparticles for Potential Drug Delivery Applications

Amine-modified starch nanoparticles were prepared from native sago starch (Metroxylon sagu) by reacting sago starch with sodium periodate and followed by the addition of ethylenediamine for the preparation of amine-modified starch. Characteristic peaks of dialdehyde s...

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Main Author:	Awangku Abdullah Kamarol, Awg Suhai
Format:	Thesis
Language:	English
Published:	2021
Subjects:	QD Chemistry
Online Access:	http://ir.unimas.my/id/eprint/37848/1/Awangku%20Abdullah%20Kamarol%20bin%20Awang%20Suhai%20ft.pdf
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spelling	my-unimas-ir.378482023-03-06T00:44:31Z Synthesis and Characterization of Amine-Modified Starch Nanoparticles for Potential Drug Delivery Applications 2021 Awangku Abdullah Kamarol, Awg Suhai QD Chemistry Amine-modified starch nanoparticles were prepared from native sago starch (Metroxylon sagu) by reacting sago starch with sodium periodate and followed by the addition of ethylenediamine for the preparation of amine-modified starch. Characteristic peaks of dialdehyde sago starch were observed at 1738 cm-1, 576 cm-1, and 789 cm-1 indicating the presence of C=O, hemiacetal formation dialdehyde sago starch and vibration of skeletal pyranose glucose chain, respectively. FTIR spectra of amine-modified starch showed the absorption peaks at around 3400 cm-1 and 1640 cm-1 which was attributed to N-H stretching and the presence of C=N functional group. Mean particle diameter of the aminemodified starch nanoparticles obtained by controlled nanoprecipitation method through drop-wise addition of amine-modified starch solution into excess ethanol solution were between 170 - 280 nm. It was also found that amine-modified starch nanoparticles achieved maximum loading efficiency and capacity of curcumin at 74.6% and 3.27 mg.mg1 , respectively. Further assessment was carried out on the in – vitro releases in which the curcumin was released within 10 hours at pH 1.2 (simulated gastric fluid condition), 12 hours at pH 7.4 (simulated blood condition), and 18 hours at pH 8.6 (simulated intestinal fluid condition). The release of curcumin from amine-modified starch nanoparticles were best - fitted with Zero - order kinetic model, which indicated that curcumin was release through diffusion and influenced by surface erosion and swelling of the nanoparticles. Universiti Malaysia Sarawak (UNIMAS) 2021 Thesis http://ir.unimas.my/id/eprint/37848/ http://ir.unimas.my/id/eprint/37848/1/Awangku%20Abdullah%20Kamarol%20bin%20Awang%20Suhai%20ft.pdf text en validuser masters Universiti Malaysia Sarawak Faculty of Resource Science and Technology
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Awangku Abdullah Kamarol, Awg Suhai Synthesis and Characterization of Amine-Modified Starch Nanoparticles for Potential Drug Delivery Applications
description	Amine-modified starch nanoparticles were prepared from native sago starch (Metroxylon sagu) by reacting sago starch with sodium periodate and followed by the addition of ethylenediamine for the preparation of amine-modified starch. Characteristic peaks of dialdehyde sago starch were observed at 1738 cm-1, 576 cm-1, and 789 cm-1 indicating the presence of C=O, hemiacetal formation dialdehyde sago starch and vibration of skeletal pyranose glucose chain, respectively. FTIR spectra of amine-modified starch showed the absorption peaks at around 3400 cm-1 and 1640 cm-1 which was attributed to N-H stretching and the presence of C=N functional group. Mean particle diameter of the aminemodified starch nanoparticles obtained by controlled nanoprecipitation method through drop-wise addition of amine-modified starch solution into excess ethanol solution were between 170 - 280 nm. It was also found that amine-modified starch nanoparticles achieved maximum loading efficiency and capacity of curcumin at 74.6% and 3.27 mg.mg1 , respectively. Further assessment was carried out on the in – vitro releases in which the curcumin was released within 10 hours at pH 1.2 (simulated gastric fluid condition), 12 hours at pH 7.4 (simulated blood condition), and 18 hours at pH 8.6 (simulated intestinal fluid condition). The release of curcumin from amine-modified starch nanoparticles were best - fitted with Zero - order kinetic model, which indicated that curcumin was release through diffusion and influenced by surface erosion and swelling of the nanoparticles.
format	Thesis
qualification_level	Master's degree
author	Awangku Abdullah Kamarol, Awg Suhai
author_facet	Awangku Abdullah Kamarol, Awg Suhai
author_sort	Awangku Abdullah Kamarol, Awg Suhai
title	Synthesis and Characterization of Amine-Modified Starch Nanoparticles for Potential Drug Delivery Applications
title_short	Synthesis and Characterization of Amine-Modified Starch Nanoparticles for Potential Drug Delivery Applications
title_full	Synthesis and Characterization of Amine-Modified Starch Nanoparticles for Potential Drug Delivery Applications
title_fullStr	Synthesis and Characterization of Amine-Modified Starch Nanoparticles for Potential Drug Delivery Applications
title_full_unstemmed	Synthesis and Characterization of Amine-Modified Starch Nanoparticles for Potential Drug Delivery Applications
title_sort	synthesis and characterization of amine-modified starch nanoparticles for potential drug delivery applications
granting_institution	Universiti Malaysia Sarawak
granting_department	Faculty of Resource Science and Technology
publishDate	2021
url	http://ir.unimas.my/id/eprint/37848/1/Awangku%20Abdullah%20Kamarol%20bin%20Awang%20Suhai%20ft.pdf
_version_	1783728491399741440

Synthesis and Characterization of Amine-Modified Starch Nanoparticles for Potential Drug Delivery Applications

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