Effect of Toxicity of Phthalate Esters during Early Vertebrate Development of Zebrafish (Danio rerio)

Dially I phthalate (DAP) and dipropy I phthalate (DPP) belong to a group of chemicals called phthalate esters (P AEs) which are commonly used as plasticisers. However, higher temperature of the environment is able to break the weak bond of the weak bonding between these chemical with polyvinyl chlor...

Full description

Saved in:

Bibliographic Details
Main Author:	Mohamad Shamil Faris, Mohamad Khalid
Format:	Thesis
Language:	English English
Published:	2018
Subjects:	QP Physiology
Online Access:	http://ir.unimas.my/id/eprint/37887/1/Mohamad%20Shamil%20Faris%20Bin%20Mohamad%20Khalid%2024pgs.pdf http://ir.unimas.my/id/eprint/37887/4/Mohamad%20Shamil%20Faris%20Bin%20Mohamad%20Khalid%20ft.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-unimas-ir.37887
record_format	uketd_dc
spelling	my-unimas-ir.378872023-03-23T08:06:45Z Effect of Toxicity of Phthalate Esters during Early Vertebrate Development of Zebrafish (Danio rerio) 2018 Mohamad Shamil Faris, Mohamad Khalid QP Physiology Dially I phthalate (DAP) and dipropy I phthalate (DPP) belong to a group of chemicals called phthalate esters (P AEs) which are commonly used as plasticisers. However, higher temperature of the environment is able to break the weak bond of the weak bonding between these chemical with polyvinyl chloride (PVC) allow it to leak into the environment. These two chemical was listed as carcinogenicity and endocrine disrupting potentials. This study was set out to study the LCso and the morphological d feet of DAP, DPP and DPP+DAP chemical on zebrafish embryonic development. Toxicity of the chemicals is determined by using pro bit analysis. The LC50 are measured at 96 hpf. Morphological defect sllch as unhatched, pericardia edema, yolk sac edema, uninflated swim bladder and tail defonnation, which were measured at 96 hpf. The LCso was determined to be at 6.58 mg/I for DPP, 5.12 mg/I for DAP and 1.71 mg/I for 0 P+DPP with 95% confidence level. The LClO was determined to be at 3.80 mg/I for DPP, 3.60 mgll for DAP, 0.92 mg/l for DAP + DPP with 95% confidence level. The thyroid hormone (TH) gene marker used in this study are; diodinase I(dio_l), diodinase 2(dio_2), Tli receptor alpha (Iro), TH receptor beta (trfJ), thyroid stimulating honnone beta (tshjJ) and transthyreiin (ttr). This study demonstrated that DPP, DAP, DPP+DAP indllced developmental toxicity, impaired the structure and functions of developing organ, and altered the expression of the thyroid hormone gene marker. Universiti Malaysia Sarawak, (UNIMAS) 2018 Thesis http://ir.unimas.my/id/eprint/37887/ http://ir.unimas.my/id/eprint/37887/1/Mohamad%20Shamil%20Faris%20Bin%20Mohamad%20Khalid%2024pgs.pdf text en public http://ir.unimas.my/id/eprint/37887/4/Mohamad%20Shamil%20Faris%20Bin%20Mohamad%20Khalid%20ft.pdf text en validuser masters Universiti Malaysia Sarawak, (UNIMAS) Faculty of Resource Science and Technology
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English English
topic	QP Physiology
spellingShingle	QP Physiology Mohamad Shamil Faris, Mohamad Khalid Effect of Toxicity of Phthalate Esters during Early Vertebrate Development of Zebrafish (Danio rerio)
description	Dially I phthalate (DAP) and dipropy I phthalate (DPP) belong to a group of chemicals called phthalate esters (P AEs) which are commonly used as plasticisers. However, higher temperature of the environment is able to break the weak bond of the weak bonding between these chemical with polyvinyl chloride (PVC) allow it to leak into the environment. These two chemical was listed as carcinogenicity and endocrine disrupting potentials. This study was set out to study the LCso and the morphological d feet of DAP, DPP and DPP+DAP chemical on zebrafish embryonic development. Toxicity of the chemicals is determined by using pro bit analysis. The LC50 are measured at 96 hpf. Morphological defect sllch as unhatched, pericardia edema, yolk sac edema, uninflated swim bladder and tail defonnation, which were measured at 96 hpf. The LCso was determined to be at 6.58 mg/I for DPP, 5.12 mg/I for DAP and 1.71 mg/I for 0 P+DPP with 95% confidence level. The LClO was determined to be at 3.80 mg/I for DPP, 3.60 mgll for DAP, 0.92 mg/l for DAP + DPP with 95% confidence level. The thyroid hormone (TH) gene marker used in this study are; diodinase I(dio_l), diodinase 2(dio_2), Tli receptor alpha (Iro), TH receptor beta (trfJ), thyroid stimulating honnone beta (tshjJ) and transthyreiin (ttr). This study demonstrated that DPP, DAP, DPP+DAP indllced developmental toxicity, impaired the structure and functions of developing organ, and altered the expression of the thyroid hormone gene marker.
format	Thesis
qualification_level	Master's degree
author	Mohamad Shamil Faris, Mohamad Khalid
author_facet	Mohamad Shamil Faris, Mohamad Khalid
author_sort	Mohamad Shamil Faris, Mohamad Khalid
title	Effect of Toxicity of Phthalate Esters during Early Vertebrate Development of Zebrafish (Danio rerio)
title_short	Effect of Toxicity of Phthalate Esters during Early Vertebrate Development of Zebrafish (Danio rerio)
title_full	Effect of Toxicity of Phthalate Esters during Early Vertebrate Development of Zebrafish (Danio rerio)
title_fullStr	Effect of Toxicity of Phthalate Esters during Early Vertebrate Development of Zebrafish (Danio rerio)
title_full_unstemmed	Effect of Toxicity of Phthalate Esters during Early Vertebrate Development of Zebrafish (Danio rerio)
title_sort	effect of toxicity of phthalate esters during early vertebrate development of zebrafish (danio rerio)
granting_institution	Universiti Malaysia Sarawak, (UNIMAS)
granting_department	Faculty of Resource Science and Technology
publishDate	2018
url	http://ir.unimas.my/id/eprint/37887/1/Mohamad%20Shamil%20Faris%20Bin%20Mohamad%20Khalid%2024pgs.pdf http://ir.unimas.my/id/eprint/37887/4/Mohamad%20Shamil%20Faris%20Bin%20Mohamad%20Khalid%20ft.pdf
_version_	1783728492862504960

Effect of Toxicity of Phthalate Esters during Early Vertebrate Development of Zebrafish (Danio rerio)

Similar Items