Chromosome fragility in nasopharyngeal carcinoma (NPC)

Nasopharyngeal carcinoma (NPC) is reported to be associated with Epstein-Barr virus (EBV) infection as well as genetic alterations in the nasopharyngeal epithelium. These include common deletions at 3p, 9p, 11q, 13q and 14q; and additions at 1q, 3q, 8q, 11q and 12p. The 11q23 which contains the Mixe...

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Main Author:	Yee, Peter Han Chung
Format:	Thesis
Language:	English
Published:	2007
Subjects:	RC0254 Neoplasms Tumors Oncology (including Cancer)
Online Access:	http://ir.unimas.my/id/eprint/603/2/Peter%20Han%20Chung.pdf
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id	my-unimas-ir.603
record_format	uketd_dc
spelling	my-unimas-ir.6032023-06-12T07:04:58Z Chromosome fragility in nasopharyngeal carcinoma (NPC) 2007 Yee, Peter Han Chung RC0254 Neoplasms. Tumors. Oncology (including Cancer) Nasopharyngeal carcinoma (NPC) is reported to be associated with Epstein-Barr virus (EBV) infection as well as genetic alterations in the nasopharyngeal epithelium. These include common deletions at 3p, 9p, 11q, 13q and 14q; and additions at 1q, 3q, 8q, 11q and 12p. The 11q23 which contains the Mixed Lineage Leukaemia (MLL) gene appears to be the common region of deletion. Till date, the mechanism of chromosome rearrangements (addition or deletion) is unknown. However, apoptosis induced chromosome break within the MLL gne have been reported in the leukaemia cells. Thus, the aim of this project is to elucidate the role of apoptosis /EBV-induced apoptosis which may lead to chromosomal rearrangement in NPC. Materials and Methods: NPC cell line was treated with apoptotic stimuli and purified DNA fragments were separated on agarose gel. Universiti Malaysia Sarawak, (UNIMAS) 2007 Thesis http://ir.unimas.my/id/eprint/603/ http://ir.unimas.my/id/eprint/603/2/Peter%20Han%20Chung.pdf text en validuser masters Universiti Malaysia Sarawak (UNIMAS) Faculty of Medicine and Human Sciences
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	RC0254 Neoplasms Tumors Oncology (including Cancer)
spellingShingle	RC0254 Neoplasms Tumors Oncology (including Cancer) Yee, Peter Han Chung Chromosome fragility in nasopharyngeal carcinoma (NPC)
description	Nasopharyngeal carcinoma (NPC) is reported to be associated with Epstein-Barr virus (EBV) infection as well as genetic alterations in the nasopharyngeal epithelium. These include common deletions at 3p, 9p, 11q, 13q and 14q; and additions at 1q, 3q, 8q, 11q and 12p. The 11q23 which contains the Mixed Lineage Leukaemia (MLL) gene appears to be the common region of deletion. Till date, the mechanism of chromosome rearrangements (addition or deletion) is unknown. However, apoptosis induced chromosome break within the MLL gne have been reported in the leukaemia cells. Thus, the aim of this project is to elucidate the role of apoptosis /EBV-induced apoptosis which may lead to chromosomal rearrangement in NPC. Materials and Methods: NPC cell line was treated with apoptotic stimuli and purified DNA fragments were separated on agarose gel.
format	Thesis
qualification_level	Master's degree
author	Yee, Peter Han Chung
author_facet	Yee, Peter Han Chung
author_sort	Yee, Peter Han Chung
title	Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_short	Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_full	Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_fullStr	Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_full_unstemmed	Chromosome fragility in nasopharyngeal carcinoma (NPC)
title_sort	chromosome fragility in nasopharyngeal carcinoma (npc)
granting_institution	Universiti Malaysia Sarawak (UNIMAS)
granting_department	Faculty of Medicine and Human Sciences
publishDate	2007
url	http://ir.unimas.my/id/eprint/603/2/Peter%20Han%20Chung.pdf
_version_	1783727894814523392

Chromosome fragility in nasopharyngeal carcinoma (NPC)

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