Synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities

Two series of bis-substituted thiourea derivatives 40a-e and tri-substituted thiourea derivatives 42a-i have been successfully synthesised by reaction of isothiocyanate intermediates with series of amines. 1,3-benzenedicarbonyl chloride 9 and 1,3,5- benzenetricarbonyl chloride 46 were utilized as a...

Full description

Saved in:

Bibliographic Details
Main Author:	Wan Sharifatun Handayani, binti Wan Zullkiplee
Format:	Thesis
Language:	English
Published:	2014
Subjects:	QD Chemistry
Online Access:	http://ir.unimas.my/id/eprint/8356/4/Sharifatun%20%28full%29.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-unimas-ir.8356
record_format	uketd_dc
spelling	my-unimas-ir.83562024-02-27T07:56:22Z Synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities 2014 Wan Sharifatun Handayani, binti Wan Zullkiplee QD Chemistry Two series of bis-substituted thiourea derivatives 40a-e and tri-substituted thiourea derivatives 42a-i have been successfully synthesised by reaction of isothiocyanate intermediates with series of amines. 1,3-benzenedicarbonyl chloride 9 and 1,3,5- benzenetricarbonyl chloride 46 were utilized as a scaffold to prepare the isothiocyanate intermediates and formed 40a-e and 42a-i respectively. The synthesis of proposed hexasubstituted thiourea derivatives was done by reacting hexachlorocyclotriphosphazene 4 as a precursor and formed six unexpected thiourea derivatives 43a-f. The preparation of unexpected thiourea products was triggered by the formation of HCl in the reaction system due to existence of free chlorine atoms which mildly dissociated from 4. The synthesis of the proposed hexa-substituted thiourea derivatives was continued via aminolysis reaction of 4 with single thiourea compounds 43a-i but the reaction was unsuccessful. All synthesised products were characterised using CHNS elemental analysis, FTIR, 1H NMR, 13C NMR and 31P NMR spectroscopic techniques. Antibacterial assay of all synthesised products was carried out using turbidimetric method against the growth of Escherichia Coliform sp. (E. coli). The results indicated that only compounds 42a-i which bear three thiourea moieties showed significant antibacterial activities. The effects of constituents and structure of the investigated compounds on the antibacterial performance were discussed. Universiti Malaysia Sarawak, (UNIMAS) 2014 Thesis http://ir.unimas.my/id/eprint/8356/ http://ir.unimas.my/id/eprint/8356/4/Sharifatun%20%28full%29.pdf text en validuser masters Universiti Malaysia Sarawak, (UNIMAS) Faculty of Resource Science and Technology.
institution	Universiti Malaysia Sarawak
collection	UNIMAS Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Wan Sharifatun Handayani, binti Wan Zullkiplee Synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities
description	Two series of bis-substituted thiourea derivatives 40a-e and tri-substituted thiourea derivatives 42a-i have been successfully synthesised by reaction of isothiocyanate intermediates with series of amines. 1,3-benzenedicarbonyl chloride 9 and 1,3,5- benzenetricarbonyl chloride 46 were utilized as a scaffold to prepare the isothiocyanate intermediates and formed 40a-e and 42a-i respectively. The synthesis of proposed hexasubstituted thiourea derivatives was done by reacting hexachlorocyclotriphosphazene 4 as a precursor and formed six unexpected thiourea derivatives 43a-f. The preparation of unexpected thiourea products was triggered by the formation of HCl in the reaction system due to existence of free chlorine atoms which mildly dissociated from 4. The synthesis of the proposed hexa-substituted thiourea derivatives was continued via aminolysis reaction of 4 with single thiourea compounds 43a-i but the reaction was unsuccessful. All synthesised products were characterised using CHNS elemental analysis, FTIR, 1H NMR, 13C NMR and 31P NMR spectroscopic techniques. Antibacterial assay of all synthesised products was carried out using turbidimetric method against the growth of Escherichia Coliform sp. (E. coli). The results indicated that only compounds 42a-i which bear three thiourea moieties showed significant antibacterial activities. The effects of constituents and structure of the investigated compounds on the antibacterial performance were discussed.
format	Thesis
qualification_level	Master's degree
author	Wan Sharifatun Handayani, binti Wan Zullkiplee
author_facet	Wan Sharifatun Handayani, binti Wan Zullkiplee
author_sort	Wan Sharifatun Handayani, binti Wan Zullkiplee
title	Synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities
title_short	Synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities
title_full	Synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities
title_fullStr	Synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities
title_full_unstemmed	Synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities
title_sort	synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities
granting_institution	Universiti Malaysia Sarawak, (UNIMAS)
granting_department	Faculty of Resource Science and Technology.
publishDate	2014
url	http://ir.unimas.my/id/eprint/8356/4/Sharifatun%20%28full%29.pdf
_version_	1794023012684529664

Synthesis and characterisation of multi-substituted thiourea derivatives and their antibacterial activities

Similar Items