Effect of Breast Cyst Fluid on Oestrone Sulphatase Activity in Breast Cancer Celllines

Effect of Breast Cyst Fluid on Oestrone Sulphatase Activity in Breast Cancer Celllines

Breast cancer is the most common cancer in women worldwide. Although breast cancers are generally oestrogen receptor positive initially, a substantial proportion become oestrogen receptor negative. Oestrogen receptor positive breast cancers are associated with a better prognosis than oestrogen re...

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Main Author: El-Sadig, Rasha El-Hag
Format: Thesis
Language:English
English
Published: 2000
Subjects:
Online Access:http://psasir.upm.edu.my/id/eprint/11207/1/FPSK_M_2000_4.pdf
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spelling my-upm-ir.112072024-06-10T04:23:03Z Effect of Breast Cyst Fluid on Oestrone Sulphatase Activity in Breast Cancer Celllines 2000-09 El-Sadig, Rasha El-Hag Breast cancer is the most common cancer in women worldwide. Although breast cancers are generally oestrogen receptor positive initially, a substantial proportion become oestrogen receptor negative. Oestrogen receptor positive breast cancers are associated with a better prognosis than oestrogen receptor negative breast cancers as they are more responsive to hormonal therapy. Breast cyst fluid (BCF) is known to be a rich source of steroid hormones and growth factors. These substances may have significant effects on mammary epithelial cell growth and oestrogen metabolism in the breast and may, thus, play important roles in the pathophysiology and development of breast cancer. Oestrone sulphate acts as a large reservoir of active oestrogens in the breast and is converted to oestrone by the enzyme oestrone sulphatase. The aims of the present study were to assess the effects of BCF on cell growth of, and oestrone sulphatase activity in the MCF-7 oestrogen 2000-09 Thesis http://psasir.upm.edu.my/id/eprint/11207/ http://psasir.upm.edu.my/id/eprint/11207/1/FPSK_M_2000_4.pdf text en public masters Universiti Putra Malaysia Faculty of Medicine and Health Science Lai, Leslie C. English
institution Universiti Putra Malaysia
collection PSAS Institutional Repository
language English
English
advisor Lai, Leslie C.
topic


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El-Sadig, Rasha El-Hag
Effect of Breast Cyst Fluid on Oestrone Sulphatase Activity in Breast Cancer Celllines
description Breast cancer is the most common cancer in women worldwide. Although breast cancers are generally oestrogen receptor positive initially, a substantial proportion become oestrogen receptor negative. Oestrogen receptor positive breast cancers are associated with a better prognosis than oestrogen receptor negative breast cancers as they are more responsive to hormonal therapy. Breast cyst fluid (BCF) is known to be a rich source of steroid hormones and growth factors. These substances may have significant effects on mammary epithelial cell growth and oestrogen metabolism in the breast and may, thus, play important roles in the pathophysiology and development of breast cancer. Oestrone sulphate acts as a large reservoir of active oestrogens in the breast and is converted to oestrone by the enzyme oestrone sulphatase. The aims of the present study were to assess the effects of BCF on cell growth of, and oestrone sulphatase activity in the MCF-7 oestrogen
format Thesis
qualification_level Master's degree
author El-Sadig, Rasha El-Hag
author_facet El-Sadig, Rasha El-Hag
author_sort El-Sadig, Rasha El-Hag
title Effect of Breast Cyst Fluid on Oestrone Sulphatase Activity in Breast Cancer Celllines
title_short Effect of Breast Cyst Fluid on Oestrone Sulphatase Activity in Breast Cancer Celllines
title_full Effect of Breast Cyst Fluid on Oestrone Sulphatase Activity in Breast Cancer Celllines
title_fullStr Effect of Breast Cyst Fluid on Oestrone Sulphatase Activity in Breast Cancer Celllines
title_full_unstemmed Effect of Breast Cyst Fluid on Oestrone Sulphatase Activity in Breast Cancer Celllines
title_sort effect of breast cyst fluid on oestrone sulphatase activity in breast cancer celllines
granting_institution Universiti Putra Malaysia
granting_department Faculty of Medicine and Health Science
publishDate 2000
url http://psasir.upm.edu.my/id/eprint/11207/1/FPSK_M_2000_4.pdf
_version_ 1804888624107356160

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