Screening Of Malaysian Medicinal Plants For Immunomodulatory And Haemolytic Activities
Twenty-six water-soluble extracts from eighteen local medicinal plant specirs and fourteen methanol extracts from ten medicinal plants were screened in order to find new immunomodulating substances from those medicinal plants. Effects on lymphocyte proliferation and macrophage function in host de...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English English |
| Published: |
2003
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/11249/1/FPSK_M_2003_6_A.pdf |
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| Summary: | Twenty-six water-soluble extracts from eighteen local medicinal plant specirs
and fourteen methanol extracts from ten medicinal plants were screened in
order to find new immunomodulating substances from those medicinal plants.
Effects on lymphocyte proliferation and macrophage function in host defense
mechanism including the nitric oxide (NO) production, phagocytic activity and
intracellular killing ability were tested. Lymphocyte or macrophage was treated
with those extracts at the concentration of 2.5 - 50J..lg/ ml. Four of the water-soluble
extracts shows mitogenicity where it causes highest mitogenicity at
different concentrations. Both methanol and water-soluble extracts failed to
alter or improve macrophage function neither of its phagocytic activity nor its
intracellular killing ability. The water extracts of S. torvum (stem bark), C.
asiatica, S. grandiflora, U. lobata (stem bark) and G. vulgaris (leaves) produce NO
significantly. Apart from that, haemolyti c activity was also determined. |
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