Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep

Signal grass (Brachiaria decumbens) is widely grown on livestock farms in many countries including Malaysia due to its high productivity and nutritive value. Unfortunately, it is toxic to sheep and goats causing a severe hepatic and renal damage, and death. Two experiments were conducted to deter...

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Main Author:	Hussain, Mohd Khairi
Format:	Thesis
Language:	English English
Published:	2003
Subjects:
Online Access:	http://psasir.upm.edu.my/id/eprint/11261/1/FPSK_M_2003_15.pdf
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id	my-upm-ir.11261
record_format	uketd_dc
spelling	my-upm-ir.112612024-06-13T02:50:31Z Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep 2003-07 Hussain, Mohd Khairi Signal grass (Brachiaria decumbens) is widely grown on livestock farms in many countries including Malaysia due to its high productivity and nutritive value. Unfortunately, it is toxic to sheep and goats causing a severe hepatic and renal damage, and death. Two experiments were conducted to determine the effect of the toxicity of signal grass (B. decumbens) on the activity of drug-metabolizing enzymes (DME) in sheep and cattle. It was hypothesized that the activities of selected enzymes would be affected during intoxication and that differences in the activity level of the enzymes in the two species might explain why cattle were safe from the toxic effect of the grass. Twenty-three healthy Wiltshire-Malin crossed rams, aged 1 4- 1 6 months were used, fifteen for the first experiment and eight for the later. In the first experiment, aniline 4-hydroxylase (A4H), aminopyrine N-demethylase (AND), UDP-glucuronyl transferase (UDPGT), glutathione S-transferase (GST) and cytochrome P450 of the liver and kidney of the control and intoxicated sheep were 2003-07 Thesis http://psasir.upm.edu.my/id/eprint/11261/ http://psasir.upm.edu.my/id/eprint/11261/1/FPSK_M_2003_15.pdf text en public masters Universiti Putra Malaysia Faculty of Medicine and Health Science English
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English English
topic
spellingShingle	Hussain, Mohd Khairi Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep
description	Signal grass (Brachiaria decumbens) is widely grown on livestock farms in many countries including Malaysia due to its high productivity and nutritive value. Unfortunately, it is toxic to sheep and goats causing a severe hepatic and renal damage, and death. Two experiments were conducted to determine the effect of the toxicity of signal grass (B. decumbens) on the activity of drug-metabolizing enzymes (DME) in sheep and cattle. It was hypothesized that the activities of selected enzymes would be affected during intoxication and that differences in the activity level of the enzymes in the two species might explain why cattle were safe from the toxic effect of the grass. Twenty-three healthy Wiltshire-Malin crossed rams, aged 1 4- 1 6 months were used, fifteen for the first experiment and eight for the later. In the first experiment, aniline 4-hydroxylase (A4H), aminopyrine N-demethylase (AND), UDP-glucuronyl transferase (UDPGT), glutathione S-transferase (GST) and cytochrome P450 of the liver and kidney of the control and intoxicated sheep were
format	Thesis
qualification_level	Master's degree
author	Hussain, Mohd Khairi
author_facet	Hussain, Mohd Khairi
author_sort	Hussain, Mohd Khairi
title	Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep
title_short	Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep
title_full	Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep
title_fullStr	Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep
title_full_unstemmed	Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep
title_sort	toxic effects of signal grass (brachiaria decumbens) on drug- metabolizing enzyme activities in sheep
granting_institution	Universiti Putra Malaysia
granting_department	Faculty of Medicine and Health Science
publishDate	2003
url	http://psasir.upm.edu.my/id/eprint/11261/1/FPSK_M_2003_15.pdf
_version_	1804888633414516736

Toxic Effects Of Signal Grass (Brachiaria Decumbens) On Drug- Metabolizing Enzyme Activities In Sheep

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