Wound Healing and Antioxidant Properties of Eucheuma Cottonii Extract on Sprague Dawley Rats
Wounds and their treatment are a big burden on the healthcare system, both in terms of cost, time and energy of care required. The lost in productivity and decreased quality of life is immeasurable. This study reports on the potential wound healing and antioxidant properties of oral consumption o...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English English |
| Published: |
2009
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/12008/1/FSTM_2009_31_A.pdf |
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| Summary: | Wounds and their treatment are a big burden on the healthcare system, both in terms
of cost, time and energy of care required. The lost in productivity and decreased
quality of life is immeasurable. This study reports on the potential wound healing and
antioxidant properties of oral consumption of ethanolic and aqueous extracts of
Eucheuma cottonii. Two cm diameter excision of skin wound model was used, with
honey (100 mg/kg body weight) as positive control and untreated normal rats as
negative control groups. Both extracts significantly (P<0.05) increased the rate of
wound contraction, better than honey. The extracts decreased lipid peroxidation in the
plasma and increased erythrocyte antioxidant enzyme activities (superoxide
dismutase) and reduced glutathione compared to both the positive and negative
control groups. The ethanolic extract was more effective than the aqueous extract by
20%. Histopathological wound tissue observations showed both extracts significantly |
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