Wound Healing and Antioxidant Properties of Eucheuma Cottonii Extract on Sprague Dawley Rats

Wounds and their treatment are a big burden on the healthcare system, both in terms of cost, time and energy of care required. The lost in productivity and decreased quality of life is immeasurable. This study reports on the potential wound healing and antioxidant properties of oral consumption o...

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Main Author: Fard, Samaneh Ghasemi
Format: Thesis
Language:English
English
Published: 2009
Subjects:
Online Access:http://psasir.upm.edu.my/id/eprint/12008/1/FSTM_2009_31_A.pdf
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spelling my-upm-ir.120082013-05-27T07:50:46Z Wound Healing and Antioxidant Properties of Eucheuma Cottonii Extract on Sprague Dawley Rats 2009 Fard, Samaneh Ghasemi Wounds and their treatment are a big burden on the healthcare system, both in terms of cost, time and energy of care required. The lost in productivity and decreased quality of life is immeasurable. This study reports on the potential wound healing and antioxidant properties of oral consumption of ethanolic and aqueous extracts of Eucheuma cottonii. Two cm diameter excision of skin wound model was used, with honey (100 mg/kg body weight) as positive control and untreated normal rats as negative control groups. Both extracts significantly (P<0.05) increased the rate of wound contraction, better than honey. The extracts decreased lipid peroxidation in the plasma and increased erythrocyte antioxidant enzyme activities (superoxide dismutase) and reduced glutathione compared to both the positive and negative control groups. The ethanolic extract was more effective than the aqueous extract by 20%. Histopathological wound tissue observations showed both extracts significantly Wound healing Rats Marine algae - Case studies 2009 Thesis http://psasir.upm.edu.my/id/eprint/12008/ http://psasir.upm.edu.my/id/eprint/12008/1/FSTM_2009_31_A.pdf application/pdf en public masters Universiti Putra Malaysia Wound healing Rats Marine algae - Case studies Faculty of Food Science and Biotechnology English
institution Universiti Putra Malaysia
collection PSAS Institutional Repository
language English
English
topic Wound healing
Rats
Marine algae - Case studies
spellingShingle Wound healing
Rats
Marine algae - Case studies
Fard, Samaneh Ghasemi
Wound Healing and Antioxidant Properties of Eucheuma Cottonii Extract on Sprague Dawley Rats
description Wounds and their treatment are a big burden on the healthcare system, both in terms of cost, time and energy of care required. The lost in productivity and decreased quality of life is immeasurable. This study reports on the potential wound healing and antioxidant properties of oral consumption of ethanolic and aqueous extracts of Eucheuma cottonii. Two cm diameter excision of skin wound model was used, with honey (100 mg/kg body weight) as positive control and untreated normal rats as negative control groups. Both extracts significantly (P<0.05) increased the rate of wound contraction, better than honey. The extracts decreased lipid peroxidation in the plasma and increased erythrocyte antioxidant enzyme activities (superoxide dismutase) and reduced glutathione compared to both the positive and negative control groups. The ethanolic extract was more effective than the aqueous extract by 20%. Histopathological wound tissue observations showed both extracts significantly
format Thesis
qualification_level Master's degree
author Fard, Samaneh Ghasemi
author_facet Fard, Samaneh Ghasemi
author_sort Fard, Samaneh Ghasemi
title Wound Healing and Antioxidant Properties of Eucheuma Cottonii Extract on Sprague Dawley Rats
title_short Wound Healing and Antioxidant Properties of Eucheuma Cottonii Extract on Sprague Dawley Rats
title_full Wound Healing and Antioxidant Properties of Eucheuma Cottonii Extract on Sprague Dawley Rats
title_fullStr Wound Healing and Antioxidant Properties of Eucheuma Cottonii Extract on Sprague Dawley Rats
title_full_unstemmed Wound Healing and Antioxidant Properties of Eucheuma Cottonii Extract on Sprague Dawley Rats
title_sort wound healing and antioxidant properties of eucheuma cottonii extract on sprague dawley rats
granting_institution Universiti Putra Malaysia
granting_department Faculty of Food Science and Biotechnology
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/12008/1/FSTM_2009_31_A.pdf
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