Nutritional Composition, Toxic ad Antioxidant Properties of Aqueous Extracts of Anacardium Occidentale Linn. Leaves and their Potential Benefits in Atherosclerosis-Induced Rabbits

Atherosclerosis is the main underlying pathology behind cardiovascular diseases (CVD), which is a major cause of disability and premature death in the world. This present study aimed to investigate the anti-atherosclerotic, hypocholesterolemic, changes in the erythrocyte antioxidant enzymes, hepatop...

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Main Author:	Fazil, Muhammad Nor Fazali
Format:	Thesis
Language:	English English
Published:	2011
Subjects:	Nutritional Physiological Phenomena
Online Access:	http://psasir.upm.edu.my/id/eprint/21441/1/FPSK%28m%29_2011_24R.pdf
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id	my-upm-ir.21441
record_format	uketd_dc
spelling	my-upm-ir.214412022-01-26T04:40:28Z Nutritional Composition, Toxic ad Antioxidant Properties of Aqueous Extracts of Anacardium Occidentale Linn. Leaves and their Potential Benefits in Atherosclerosis-Induced Rabbits 2011-09 Fazil, Muhammad Nor Fazali Atherosclerosis is the main underlying pathology behind cardiovascular diseases (CVD), which is a major cause of disability and premature death in the world. This present study aimed to investigate the anti-atherosclerotic, hypocholesterolemic, changes in the erythrocyte antioxidant enzymes, hepatoprotective and toxicity effects of the aqueous extract of the leaves of Anacardium occidentale Linn. (AOE) in atherosclerosis-induced rabbits. In vitro antioxidative properties of AOE were assessed via DPPH free radical scavenging and ferric reducing antioxidant power assay (FRAP) while in vitro toxicity potential of AOE was determined via brine shrimp lethality test (BSLT). The total phenolic content of AOE was evaluated via Folin-Ciocalteau method. Atherosclerosis was induced by giving 0.5% high cholesterol diet and AOE of various doses (100, 200 and 400 mg/kg) were administered via force-feeding once daily for 12 weeks. Blood samples were withdrawn via ear vein lobe every 4 weeks. It was demonstrated that AOE was not toxic, contain phenolic compounds and posses comparable antioxidant properties with Buthylated Hydroxytoluene (BHT) in free radical scavenging and FRAP assay. Supplementation of AOE to the experimental animals compared to the rabbits receiving the high cholesteriol diet alone significantly retarded (p<0.05) the atheromatous plaque formation and significantly lower (p<0.05) the low density lipoprotein and triglycerides levels. The extract also posses antioxidative effects in vivo by significantly lower (p<0.05) the lipid peroxidation product (malondialdehyde) and was able to significantly increased (p<005) the catalase levels. The extract also exerts hepatoprotective effect by normalizing the liver enzymes (aspartate transaminase, alkaline phosphatase, alanine transaminase and gamma-glutamyltransferase). In conclusion, this study indicates the potential of AOE as anti-atherosclerotic, hypocholesterolemic and antioxidative agent. Nutritional Physiological Phenomena 2011-09 Thesis http://psasir.upm.edu.my/id/eprint/21441/ http://psasir.upm.edu.my/id/eprint/21441/1/FPSK%28m%29_2011_24R.pdf application/pdf en public masters Universiti Putra Malaysia Nutritional Physiological Phenomena Faculty of Medicine and Health Sciences English
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English English
topic	Nutritional Physiological Phenomena
spellingShingle	Nutritional Physiological Phenomena Fazil, Muhammad Nor Fazali Nutritional Composition, Toxic ad Antioxidant Properties of Aqueous Extracts of Anacardium Occidentale Linn. Leaves and their Potential Benefits in Atherosclerosis-Induced Rabbits
description	Atherosclerosis is the main underlying pathology behind cardiovascular diseases (CVD), which is a major cause of disability and premature death in the world. This present study aimed to investigate the anti-atherosclerotic, hypocholesterolemic, changes in the erythrocyte antioxidant enzymes, hepatoprotective and toxicity effects of the aqueous extract of the leaves of Anacardium occidentale Linn. (AOE) in atherosclerosis-induced rabbits. In vitro antioxidative properties of AOE were assessed via DPPH free radical scavenging and ferric reducing antioxidant power assay (FRAP) while in vitro toxicity potential of AOE was determined via brine shrimp lethality test (BSLT). The total phenolic content of AOE was evaluated via Folin-Ciocalteau method. Atherosclerosis was induced by giving 0.5% high cholesterol diet and AOE of various doses (100, 200 and 400 mg/kg) were administered via force-feeding once daily for 12 weeks. Blood samples were withdrawn via ear vein lobe every 4 weeks. It was demonstrated that AOE was not toxic, contain phenolic compounds and posses comparable antioxidant properties with Buthylated Hydroxytoluene (BHT) in free radical scavenging and FRAP assay. Supplementation of AOE to the experimental animals compared to the rabbits receiving the high cholesteriol diet alone significantly retarded (p<0.05) the atheromatous plaque formation and significantly lower (p<0.05) the low density lipoprotein and triglycerides levels. The extract also posses antioxidative effects in vivo by significantly lower (p<0.05) the lipid peroxidation product (malondialdehyde) and was able to significantly increased (p<005) the catalase levels. The extract also exerts hepatoprotective effect by normalizing the liver enzymes (aspartate transaminase, alkaline phosphatase, alanine transaminase and gamma-glutamyltransferase). In conclusion, this study indicates the potential of AOE as anti-atherosclerotic, hypocholesterolemic and antioxidative agent.
format	Thesis
qualification_level	Master's degree
author	Fazil, Muhammad Nor Fazali
author_facet	Fazil, Muhammad Nor Fazali
author_sort	Fazil, Muhammad Nor Fazali
title	Nutritional Composition, Toxic ad Antioxidant Properties of Aqueous Extracts of Anacardium Occidentale Linn. Leaves and their Potential Benefits in Atherosclerosis-Induced Rabbits
title_short	Nutritional Composition, Toxic ad Antioxidant Properties of Aqueous Extracts of Anacardium Occidentale Linn. Leaves and their Potential Benefits in Atherosclerosis-Induced Rabbits
title_full	Nutritional Composition, Toxic ad Antioxidant Properties of Aqueous Extracts of Anacardium Occidentale Linn. Leaves and their Potential Benefits in Atherosclerosis-Induced Rabbits
title_fullStr	Nutritional Composition, Toxic ad Antioxidant Properties of Aqueous Extracts of Anacardium Occidentale Linn. Leaves and their Potential Benefits in Atherosclerosis-Induced Rabbits
title_full_unstemmed	Nutritional Composition, Toxic ad Antioxidant Properties of Aqueous Extracts of Anacardium Occidentale Linn. Leaves and their Potential Benefits in Atherosclerosis-Induced Rabbits
title_sort	nutritional composition, toxic ad antioxidant properties of aqueous extracts of anacardium occidentale linn. leaves and their potential benefits in atherosclerosis-induced rabbits
granting_institution	Universiti Putra Malaysia
granting_department	Faculty of Medicine and Health Sciences
publishDate	2011
url	http://psasir.upm.edu.my/id/eprint/21441/1/FPSK%28m%29_2011_24R.pdf
_version_	1747811493332647936

Nutritional Composition, Toxic ad Antioxidant Properties of Aqueous Extracts of Anacardium Occidentale Linn. Leaves and their Potential Benefits in Atherosclerosis-Induced Rabbits

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