In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit

In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit

Pharmacological studies were conducted with the aqueous extract of Tamarindus indica L. fruits (TFAE) on experimental animals for evaluating the analgesic, antipyretic, anti-inflammatory activities and to elucidate its mechanism of action. In the analgesic test, three experimental models of nocicept...

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Main Author: Md Khalid, Syamimi Md Khalid
Format: Thesis
Language:English
English
Published: 2011
Subjects:
Analgesics
Online Access:http://psasir.upm.edu.my/id/eprint/21447/1/FPSK%28m%29_2011_30R.pdf
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spelling my-upm-ir.214472022-01-26T04:42:50Z In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit 2011-06 Md Khalid, Syamimi Md Khalid Pharmacological studies were conducted with the aqueous extract of Tamarindus indica L. fruits (TFAE) on experimental animals for evaluating the analgesic, antipyretic, anti-inflammatory activities and to elucidate its mechanism of action. In the analgesic test, three experimental models of nociception used to study the analgesic activity of extract namely, acetic acid-induced abdominal constrictions test and hot-plate test in mice and formalin test in rats. TFAE produced inhibitory effect in all experimental models used. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. In addition, TFAE also produced significant inhibition effect (p<0.001) in glutamate and capsaicin-induced paw licking models. Pre-treatment with 5 mg/kg naloxone, a non-selective opioid receptor antagonist, significantly (p<0.001) antagonised the antinociceptive effect of the extract in all tests. This shows the analgesic effect is associated with stimulation of opioid receptors in central brain system. In addition, TFAE also showed anti-inflammatory activity through carrageenan-induced paw edema model and significantly (p<0.001) inhibited inflammation-induced by carrageenan edemogens. In acute chronic inflammation model, Tamarind provoked a significant reduction of both proliferative and transudative phase when tested on cotton pellet-induced granuloma model. At 600mg/kg, TFAE caused maximum inhibition of granuloma with 22.00%. TFAE also elicited antipyretic action when tested in yeast-induced hyperthermia in mice. In the rota rod test, TFAE treated mice did not show any significant motor performance alterations with the dose of 600 mg/kg and this shows that TFAE has no sedative effect. Furthermore, subacute toxicity of 28 consecutive days also shown, there were no deaths or toxic signs recorded in the rats given 1.5, 2.25 and 5.0 g/kg of TFAE. Analgesics 2011-06 Thesis http://psasir.upm.edu.my/id/eprint/21447/ http://psasir.upm.edu.my/id/eprint/21447/1/FPSK%28m%29_2011_30R.pdf application/pdf en public masters Universiti Putra Malaysia Analgesics Faculty of Medicine and Health Sciences English
institution Universiti Putra Malaysia
collection PSAS Institutional Repository
language English
English
topic Analgesics
spellingShingle Analgesics


Md Khalid, Syamimi Md Khalid
In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit
description Pharmacological studies were conducted with the aqueous extract of Tamarindus indica L. fruits (TFAE) on experimental animals for evaluating the analgesic, antipyretic, anti-inflammatory activities and to elucidate its mechanism of action. In the analgesic test, three experimental models of nociception used to study the analgesic activity of extract namely, acetic acid-induced abdominal constrictions test and hot-plate test in mice and formalin test in rats. TFAE produced inhibitory effect in all experimental models used. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. In addition, TFAE also produced significant inhibition effect (p<0.001) in glutamate and capsaicin-induced paw licking models. Pre-treatment with 5 mg/kg naloxone, a non-selective opioid receptor antagonist, significantly (p<0.001) antagonised the antinociceptive effect of the extract in all tests. This shows the analgesic effect is associated with stimulation of opioid receptors in central brain system. In addition, TFAE also showed anti-inflammatory activity through carrageenan-induced paw edema model and significantly (p<0.001) inhibited inflammation-induced by carrageenan edemogens. In acute chronic inflammation model, Tamarind provoked a significant reduction of both proliferative and transudative phase when tested on cotton pellet-induced granuloma model. At 600mg/kg, TFAE caused maximum inhibition of granuloma with 22.00%. TFAE also elicited antipyretic action when tested in yeast-induced hyperthermia in mice. In the rota rod test, TFAE treated mice did not show any significant motor performance alterations with the dose of 600 mg/kg and this shows that TFAE has no sedative effect. Furthermore, subacute toxicity of 28 consecutive days also shown, there were no deaths or toxic signs recorded in the rats given 1.5, 2.25 and 5.0 g/kg of TFAE.
format Thesis
qualification_level Master's degree
author Md Khalid, Syamimi Md Khalid
author_facet Md Khalid, Syamimi Md Khalid
author_sort Md Khalid, Syamimi Md Khalid
title In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit
title_short In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit
title_full In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit
title_fullStr In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit
title_full_unstemmed In vivo Evaluation of Analgesic, Anti-Inflammatory and Antipyretic Activities of Aqueous Extract from Tamarindus Indica l. Fruit
title_sort in vivo evaluation of analgesic, anti-inflammatory and antipyretic activities of aqueous extract from tamarindus indica l. fruit
granting_institution Universiti Putra Malaysia
granting_department Faculty of Medicine and Health Sciences
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/21447/1/FPSK%28m%29_2011_30R.pdf
_version_ 1747811494804848640

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