Role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients

FDG-PET/CT is a combined functional and structural multi modality imaging tool that can be utilized to detect atherosclerotic plaques. This study observed the prevalence of active and calcified plaques in selected arteries during whole-body 18F-FDG PET-CT and correlate the findings with risk factors...

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Main Author:	Shaharuddin, Shazreen
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Fluorodeoxyglucose F18
Online Access:	http://psasir.upm.edu.my/id/eprint/38698/1/FPSK%28m%29%202013%2027%20IR.pdf
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spelling	my-upm-ir.386982016-03-15T09:10:02Z Role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients 2013-10 Shaharuddin, Shazreen FDG-PET/CT is a combined functional and structural multi modality imaging tool that can be utilized to detect atherosclerotic plaques. This study observed the prevalence of active and calcified plaques in selected arteries during whole-body 18F-FDG PET-CT and correlate the findings with risk factors in coronary artery disease. Beside that, the relationship of active and calcified plaque activity with inflammatory biomarker were determine from the blood marker. The record of 47 patients, which were divided into 17 patients retrospectively and 30 patient prospectively alongside serum inflammatory marker (eg.IL-6 and CRP) and cholesterol (eg lipid profile) undergone whole body FDG PET-CT study in various oncology cases were reviewed. To evaluate the cutoff value for abnormal uptake, retrospective study was conducted to identify patient at risk of developing vascular disease. Mean age was 58±10.3 years old. The presence of 18F-FDG uptake and calcification in selected vascular walls were evaluated. The composition of plaque were recorded using CT value in Housfield unit (HU max). The intensity of 18F-FDG uptake was measured as maximum blood-normalized standardize uptake value (SUVmax). 18F-FDG uptake (SUVmax) and calcification (HUmax) was significantly highest in the carotid walls with (1.91±0.11) and (631.7±215.5) respectively. There was significant relationship between high BMI (overweight) with 18FDG uptake, while calcified artery significant related with hyperlipidemia, diabetes mellitus and hypertension. However the blood marker (such as C-reactive protein) showed significant with high 18FDG uptake and high calcified artery. Beside that, calcified artery showed there was no significant and direct correlation with inflamed vascular wall (SUVmax). This study showed that 18F-FDG PET-CT can be utilized in detecting focal high FDG uptake within vascular plaque in early recognition of high risk patients having coronary artery disease. Fluorodeoxyglucose F18 2013-10 Thesis http://psasir.upm.edu.my/id/eprint/38698/ http://psasir.upm.edu.my/id/eprint/38698/1/FPSK%28m%29%202013%2027%20IR.pdf application/pdf en public masters Universiti Putra Malaysia Fluorodeoxyglucose F18
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Fluorodeoxyglucose F18
spellingShingle	Fluorodeoxyglucose F18 Shaharuddin, Shazreen Role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients
description	FDG-PET/CT is a combined functional and structural multi modality imaging tool that can be utilized to detect atherosclerotic plaques. This study observed the prevalence of active and calcified plaques in selected arteries during whole-body 18F-FDG PET-CT and correlate the findings with risk factors in coronary artery disease. Beside that, the relationship of active and calcified plaque activity with inflammatory biomarker were determine from the blood marker. The record of 47 patients, which were divided into 17 patients retrospectively and 30 patient prospectively alongside serum inflammatory marker (eg.IL-6 and CRP) and cholesterol (eg lipid profile) undergone whole body FDG PET-CT study in various oncology cases were reviewed. To evaluate the cutoff value for abnormal uptake, retrospective study was conducted to identify patient at risk of developing vascular disease. Mean age was 58±10.3 years old. The presence of 18F-FDG uptake and calcification in selected vascular walls were evaluated. The composition of plaque were recorded using CT value in Housfield unit (HU max). The intensity of 18F-FDG uptake was measured as maximum blood-normalized standardize uptake value (SUVmax). 18F-FDG uptake (SUVmax) and calcification (HUmax) was significantly highest in the carotid walls with (1.91±0.11) and (631.7±215.5) respectively. There was significant relationship between high BMI (overweight) with 18FDG uptake, while calcified artery significant related with hyperlipidemia, diabetes mellitus and hypertension. However the blood marker (such as C-reactive protein) showed significant with high 18FDG uptake and high calcified artery. Beside that, calcified artery showed there was no significant and direct correlation with inflamed vascular wall (SUVmax). This study showed that 18F-FDG PET-CT can be utilized in detecting focal high FDG uptake within vascular plaque in early recognition of high risk patients having coronary artery disease.
format	Thesis
qualification_level	Master's degree
author	Shaharuddin, Shazreen
author_facet	Shaharuddin, Shazreen
author_sort	Shaharuddin, Shazreen
title	Role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients
title_short	Role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients
title_full	Role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients
title_fullStr	Role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients
title_full_unstemmed	Role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients
title_sort	role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients
granting_institution	Universiti Putra Malaysia
publishDate	2013
url	http://psasir.upm.edu.my/id/eprint/38698/1/FPSK%28m%29%202013%2027%20IR.pdf
_version_	1747811746742009856

Role of 18fluorine fluorodeoxyglucose in vulnerable plaque detection for identifying high risk patients

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