Synthesis, And Physico-Chemical and Biological Charaterization of New Schiff Bases Derived From Thiophene and Their Transition Metal Complexes

Several new Schiff bases formed from S-benzyldithiocarbazate (SBDTC) and S- methyldithiocarbazate (SMDTC) with selected aldehyde/ketones containing a thiophene ring namely, 1-(2-thienyl)-1-propanone and thiophene-2-carbaldehyde in 95 % of ethanol have been synthesized. Complexes of Cobalt(III), Nick...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Osman, Md.Uwaisulqarni
التنسيق: أطروحة
اللغة:English
English
منشور في: 2007
الموضوعات:
الوصول للمادة أونلاين:http://psasir.upm.edu.my/id/eprint/4986/1/FS_2007_8.pdf
الوسوم: إضافة وسم
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id my-upm-ir.4986
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spelling my-upm-ir.49862013-05-27T07:19:35Z Synthesis, And Physico-Chemical and Biological Charaterization of New Schiff Bases Derived From Thiophene and Their Transition Metal Complexes 2007 Osman, Md.Uwaisulqarni Several new Schiff bases formed from S-benzyldithiocarbazate (SBDTC) and S- methyldithiocarbazate (SMDTC) with selected aldehyde/ketones containing a thiophene ring namely, 1-(2-thienyl)-1-propanone and thiophene-2-carbaldehyde in 95 % of ethanol have been synthesized. Complexes of Cobalt(III), Nickel(II), Copper(II), Zinc(II) and Cadmium(II) with these Schiff bases were prepared. These compounds were characterized by elemental analyses and various physico-chemical techniques. Their thermal behaviour was also investigated. Single crystal X-ray analysis was carried out on nine single crystals. The Co(III) complexes are six-coordinated whereas, Ni(II), Zn(II) and Cd(II) complexes are four-coordinated. Unfortunately, none of the Cu(II) complexes produced single crystals but, it is proposed, that they are also four-coordinated. The Schiff bases and their metal complexes were evaluated for their cytotoxic and antimicrobial activities. Cytotoxic screening was carried out against Human ovarian cancer cells (CaOV-3), Human breast carcinoma cells with negative estrogen receptor (MDA-MB-231) and Human liver carcinoma cells (HEP-G2). Antimicrobial screening was carried out against four bacteria and three fungi. All compounds were found to have low or no activity except for Cu(SBT2P)2. H2O which is active against Bacillus subtilis-wild type (B29). Schiff bases - Synthesis. Thiophenes. Transition metals. 2007 Thesis http://psasir.upm.edu.my/id/eprint/4986/ http://psasir.upm.edu.my/id/eprint/4986/1/FS_2007_8.pdf application/pdf en public masters Universiti Putra Malaysia Schiff bases - Synthesis. Thiophenes. Transition metals. Science English
institution Universiti Putra Malaysia
collection PSAS Institutional Repository
language English
English
topic Schiff bases - Synthesis.
Thiophenes.
Transition metals.
spellingShingle Schiff bases - Synthesis.
Thiophenes.
Transition metals.
Osman, Md.Uwaisulqarni
Synthesis, And Physico-Chemical and Biological Charaterization of New Schiff Bases Derived From Thiophene and Their Transition Metal Complexes
description Several new Schiff bases formed from S-benzyldithiocarbazate (SBDTC) and S- methyldithiocarbazate (SMDTC) with selected aldehyde/ketones containing a thiophene ring namely, 1-(2-thienyl)-1-propanone and thiophene-2-carbaldehyde in 95 % of ethanol have been synthesized. Complexes of Cobalt(III), Nickel(II), Copper(II), Zinc(II) and Cadmium(II) with these Schiff bases were prepared. These compounds were characterized by elemental analyses and various physico-chemical techniques. Their thermal behaviour was also investigated. Single crystal X-ray analysis was carried out on nine single crystals. The Co(III) complexes are six-coordinated whereas, Ni(II), Zn(II) and Cd(II) complexes are four-coordinated. Unfortunately, none of the Cu(II) complexes produced single crystals but, it is proposed, that they are also four-coordinated. The Schiff bases and their metal complexes were evaluated for their cytotoxic and antimicrobial activities. Cytotoxic screening was carried out against Human ovarian cancer cells (CaOV-3), Human breast carcinoma cells with negative estrogen receptor (MDA-MB-231) and Human liver carcinoma cells (HEP-G2). Antimicrobial screening was carried out against four bacteria and three fungi. All compounds were found to have low or no activity except for Cu(SBT2P)2. H2O which is active against Bacillus subtilis-wild type (B29).
format Thesis
qualification_level Master's degree
author Osman, Md.Uwaisulqarni
author_facet Osman, Md.Uwaisulqarni
author_sort Osman, Md.Uwaisulqarni
title Synthesis, And Physico-Chemical and Biological Charaterization of New Schiff Bases Derived From Thiophene and Their Transition Metal Complexes
title_short Synthesis, And Physico-Chemical and Biological Charaterization of New Schiff Bases Derived From Thiophene and Their Transition Metal Complexes
title_full Synthesis, And Physico-Chemical and Biological Charaterization of New Schiff Bases Derived From Thiophene and Their Transition Metal Complexes
title_fullStr Synthesis, And Physico-Chemical and Biological Charaterization of New Schiff Bases Derived From Thiophene and Their Transition Metal Complexes
title_full_unstemmed Synthesis, And Physico-Chemical and Biological Charaterization of New Schiff Bases Derived From Thiophene and Their Transition Metal Complexes
title_sort synthesis, and physico-chemical and biological charaterization of new schiff bases derived from thiophene and their transition metal complexes
granting_institution Universiti Putra Malaysia
granting_department Science
publishDate 2007
url http://psasir.upm.edu.my/id/eprint/4986/1/FS_2007_8.pdf
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