Synthesis, Characterization and Elucidation of the Structure–Activity Relationship of Heteroatom Donor Ligands and Their Complexes Derived From Substituted Dithiocarbazate Derivatives
Four new substituted dithiocarbazate ligands [S-napthalen-2-ylmethyldithiocarbazate (SNMDTC), S-quinolin-2-ylmethyl-dithiocarbazate (SQ2MDTC), Sbenzyl- N-benzyldithiocarbazate (SBNBDTC) and S-methyl-N-benzyldithiocarbazate (SMNBDTC)], eight series of isomeric Schiff bases derived from different t...
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| Format: | Thesis |
| Language: | English English |
| Published: |
2008
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/5106/1/FS_2008_11.pdf |
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| Summary: | Four new substituted dithiocarbazate ligands [S-napthalen-2-ylmethyldithiocarbazate
(SNMDTC), S-quinolin-2-ylmethyl-dithiocarbazate (SQ2MDTC), Sbenzyl-
N-benzyldithiocarbazate (SBNBDTC) and S-methyl-N-benzyldithiocarbazate
(SMNBDTC)], eight series of isomeric Schiff bases derived from different types of
S-substituted dithiocarbazate and their metal complexes were successfully
synthesized and characterized. Eighteen structures were determined using single
crystal X-ray diffraction analysis. These newly synthesized compounds were
systematically designed to form structurally heterogeneous compounds for QSAR
study.
Schiff bases were derived from condensation of isomeric aldehydes and ketones, 3-
and 4-methylacetophenone and 2-, 3- and 4-acetylpyridine with different substituted
dithiocarbazate compounds. Upon complexation, all Schiff bases formed bis chelated (NS donor) complexes except for the uninegative tridentate, S-napthalen-
2yl methyl-β-N-(2-acetylpyridine)dithiocarbazate (SNM2AP) that coordinated with
metal ions via the azomethine nitrogen atom, the pyridyl nitrogen atom and the
thiolo sulfur (NNS donor)
Some of these newly synthesized compounds exhibited significant activities towards
selective strains of pathogens and marked cytotoxicity when assayed against breast
cancer estrogen receptor positive, MCF-7 and breast cancer estrogen receptor
negative, MDA-MB-231 cell lines. The biological activities of the isomeric Schiff
bases and their complexes were investigated. Most of the complexes exhibited
higher activity compared to their parent ligands upon complexation with metal ions.
The cytotoxicity data for all the compounds were used to construct QSAR model in
an attempt to elucidate the relationship between structure and bioactivity.
Satisfactory QSAR models were developed focusing on a few of the informative
descriptors based on a wide set of relatively heterogeneous compounds as evidenced
with value r2>0.6 and r2
CV> 0.5. |
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