Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole

Breast cancer is the most common cancer diagnosed and the second leading cause of cancer death among women after lung cancer. This fact had led the researchers to continuously synthesize new drugs to treat breast cancer. Thus, with this aim, new mixed-ligand metal complexes have been synthesized and...

Full description

Saved in:

Bibliographic Details
Main Author:	Mazlan, Nurul Ain
Format:	Thesis
Language:	English
Published:	2014
Subjects:	Ligands Imidazole Benzimidazoles
Online Access:	http://psasir.upm.edu.my/id/eprint/52096/1/FS%202014%2010RR.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-upm-ir.52096
record_format	uketd_dc
spelling	my-upm-ir.520962017-05-03T03:20:05Z Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole 2014-06 Mazlan, Nurul Ain Breast cancer is the most common cancer diagnosed and the second leading cause of cancer death among women after lung cancer. This fact had led the researchers to continuously synthesize new drugs to treat breast cancer. Thus, with this aim, new mixed-ligand metal complexes have been synthesized and evaluated for their biological activities in this research. Three series of tridentate Schiff bases derived from 4-methyl-3-thiosemicarbazide, 4-ethyl-3-thiosemicarbazide and 4-phenyl-3-thiosemicarbazide were synthesized using three aldehydes via condensation reactions, to form tridentate Oxygen-Nitrogen-Sulphur (ONS) containing ligands. The Schiff bases were then complexed with the imidazole or benzimidazole and Cu(II) and Ni(II) salts to produce new mixed-ligand transition metal complexes. These compounds were characterized by elemental analysis, molar conductivity,magnetic susceptibility and various spectroscopic techniques including Fourier- Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR),UltraViolet/Visible (UV/Vis) and Inductively Coupled Plasma – Atomic Emission Spectroscopy (ICP-AES) analyses. The elemental analyses support the proposed formulae for the synthesized compounds while the molar conductance values indicated that the metal complexes were essentially non-electrolytes in DMSO solution. The magnetic susceptibility measurements and spectral results support the four-coordinate (square planar) geometry in which the Schiff bases behave as the tridentate ONS donor ligand coordinating via the hydroxyl oxygen, azomethine nitrogen, and thiolo sulphur atom while the imidazole or benzimidazole coordinates as a unidentate N-donor ligand. Single Crystal X-ray crystallographic analysis of five new mixed-ligand Cu(II) and Ni(II) complexes containing imidazole or benzimidazole shows that the complex exhibit a distorted square planar structure. The Schiff bases and their metal complexes have been evaluated for their biological activities against estrogen receptor positive breast cancer cell line (MCF-7) and estrogen receptor negative breast cancer cell line (MDA-MB-231). All of the Cu(II) complexes from salicylaldehyde and 3-methoxy salicylaldehyde derivatives with five Ni(II) complexes showed marked cytotoxicity against the cell lines while all except MTSali Schiff bases and most Ni(II) complexes were found to be inactive. Ligands Imidazole Benzimidazoles 2014-06 Thesis http://psasir.upm.edu.my/id/eprint/52096/ http://psasir.upm.edu.my/id/eprint/52096/1/FS%202014%2010RR.pdf application/pdf en public masters Universiti Putra Malaysia Ligands Imidazole Benzimidazoles
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Ligands Imidazole Benzimidazoles
spellingShingle	Ligands Imidazole Benzimidazoles Mazlan, Nurul Ain Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole
description	Breast cancer is the most common cancer diagnosed and the second leading cause of cancer death among women after lung cancer. This fact had led the researchers to continuously synthesize new drugs to treat breast cancer. Thus, with this aim, new mixed-ligand metal complexes have been synthesized and evaluated for their biological activities in this research. Three series of tridentate Schiff bases derived from 4-methyl-3-thiosemicarbazide, 4-ethyl-3-thiosemicarbazide and 4-phenyl-3-thiosemicarbazide were synthesized using three aldehydes via condensation reactions, to form tridentate Oxygen-Nitrogen-Sulphur (ONS) containing ligands. The Schiff bases were then complexed with the imidazole or benzimidazole and Cu(II) and Ni(II) salts to produce new mixed-ligand transition metal complexes. These compounds were characterized by elemental analysis, molar conductivity,magnetic susceptibility and various spectroscopic techniques including Fourier- Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR),UltraViolet/Visible (UV/Vis) and Inductively Coupled Plasma – Atomic Emission Spectroscopy (ICP-AES) analyses. The elemental analyses support the proposed formulae for the synthesized compounds while the molar conductance values indicated that the metal complexes were essentially non-electrolytes in DMSO solution. The magnetic susceptibility measurements and spectral results support the four-coordinate (square planar) geometry in which the Schiff bases behave as the tridentate ONS donor ligand coordinating via the hydroxyl oxygen, azomethine nitrogen, and thiolo sulphur atom while the imidazole or benzimidazole coordinates as a unidentate N-donor ligand. Single Crystal X-ray crystallographic analysis of five new mixed-ligand Cu(II) and Ni(II) complexes containing imidazole or benzimidazole shows that the complex exhibit a distorted square planar structure. The Schiff bases and their metal complexes have been evaluated for their biological activities against estrogen receptor positive breast cancer cell line (MCF-7) and estrogen receptor negative breast cancer cell line (MDA-MB-231). All of the Cu(II) complexes from salicylaldehyde and 3-methoxy salicylaldehyde derivatives with five Ni(II) complexes showed marked cytotoxicity against the cell lines while all except MTSali Schiff bases and most Ni(II) complexes were found to be inactive.
format	Thesis
qualification_level	Master's degree
author	Mazlan, Nurul Ain
author_facet	Mazlan, Nurul Ain
author_sort	Mazlan, Nurul Ain
title	Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole
title_short	Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole
title_full	Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole
title_fullStr	Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole
title_full_unstemmed	Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole
title_sort	synthesis, characterization and biological activities of tridentate ons schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole
granting_institution	Universiti Putra Malaysia
publishDate	2014
url	http://psasir.upm.edu.my/id/eprint/52096/1/FS%202014%2010RR.pdf
_version_	1747812091209711616

Synthesis, characterization and biological activities of tridentate ons Schiff bases and their mixed-ligand metal complexes containing imidazole or benzimidazole

Similar Items