Compaction characteristics of Ficus Deltoidea jack extract powder

In Malaysia, Ficus deltoidea is locally known as Mas Cotek and is traditionally used to treat cardiovascular diseases, diabetes, and as an aphrodisiac specifically to increase male virility. The main objective of this thesis is to investigate the compressibility and compactability of Ficus deltoidea...

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Main Author:	Mohd Salleh, Faiqa Shazeaa
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Ficus (Plants) - Analysis
Online Access:	http://psasir.upm.edu.my/id/eprint/59776/7/FK%202012%20103IR.pdf
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spelling	my-upm-ir.597762018-05-30T04:03:10Z Compaction characteristics of Ficus Deltoidea jack extract powder 2012-06 Mohd Salleh, Faiqa Shazeaa In Malaysia, Ficus deltoidea is locally known as Mas Cotek and is traditionally used to treat cardiovascular diseases, diabetes, and as an aphrodisiac specifically to increase male virility. The main objective of this thesis is to investigate the compressibility and compactability of Ficus deltoidea extract powders for tableting processes. Avicel and Acdisol powders are used as excipients. Both of these powders are essentially easily soluble and disintegrate in water. The physical, material and flow properties of the powders have been investigated as it is essential to understand the compression and compaction mechanisms. The Ficus deltoidea extract powder has a particle size of less than 40 μm and was compressed into a tablet by using a 13-mmcylindrical uniaxial die. Applied pressures between 7.53 to 73.84 MPa were adopted using a universal testing machine. To further investigate the properties, the friability and modified dissolution tests were carried out. This was aimed to provide a convenient soluble form for consumers who have difficulties in swallowing tablets and chewing difficulties, whereby the tablet can dissolve easily in water and can be drunk directly. From the tests, tablets composed of Acdisol had a faster dissolve time in the modified dissolution time test compared to Avicel. Based on these stud ies, a few recommended tablet conditions have been classified from the best conditions of compression and compaction characteristic tablet. The best formulation for the tablets was a combination of 50 % and 70 % of Avicel and Acdisol with Ficus deltoidea extract powder respectively at a pressure of 73.84 MPa. As a safety measure before consumption, these three main material powders were chosen for a toxicity test, utilizing an in vitro technique for testing cancer toxicity on human cells. Thus, this study provides information concerning the extent of the application of compression and compaction characteristics for product development of Ficus deltoidea extract as a safe and healthy supplement. Ficus (Plants) - Analysis 2012-06 Thesis http://psasir.upm.edu.my/id/eprint/59776/ http://psasir.upm.edu.my/id/eprint/59776/7/FK%202012%20103IR.pdf text en public masters Universiti Putra Malaysia Ficus (Plants) - Analysis
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Ficus (Plants) - Analysis
spellingShingle	Ficus (Plants) - Analysis Mohd Salleh, Faiqa Shazeaa Compaction characteristics of Ficus Deltoidea jack extract powder
description	In Malaysia, Ficus deltoidea is locally known as Mas Cotek and is traditionally used to treat cardiovascular diseases, diabetes, and as an aphrodisiac specifically to increase male virility. The main objective of this thesis is to investigate the compressibility and compactability of Ficus deltoidea extract powders for tableting processes. Avicel and Acdisol powders are used as excipients. Both of these powders are essentially easily soluble and disintegrate in water. The physical, material and flow properties of the powders have been investigated as it is essential to understand the compression and compaction mechanisms. The Ficus deltoidea extract powder has a particle size of less than 40 μm and was compressed into a tablet by using a 13-mmcylindrical uniaxial die. Applied pressures between 7.53 to 73.84 MPa were adopted using a universal testing machine. To further investigate the properties, the friability and modified dissolution tests were carried out. This was aimed to provide a convenient soluble form for consumers who have difficulties in swallowing tablets and chewing difficulties, whereby the tablet can dissolve easily in water and can be drunk directly. From the tests, tablets composed of Acdisol had a faster dissolve time in the modified dissolution time test compared to Avicel. Based on these stud ies, a few recommended tablet conditions have been classified from the best conditions of compression and compaction characteristic tablet. The best formulation for the tablets was a combination of 50 % and 70 % of Avicel and Acdisol with Ficus deltoidea extract powder respectively at a pressure of 73.84 MPa. As a safety measure before consumption, these three main material powders were chosen for a toxicity test, utilizing an in vitro technique for testing cancer toxicity on human cells. Thus, this study provides information concerning the extent of the application of compression and compaction characteristics for product development of Ficus deltoidea extract as a safe and healthy supplement.
format	Thesis
qualification_level	Master's degree
author	Mohd Salleh, Faiqa Shazeaa
author_facet	Mohd Salleh, Faiqa Shazeaa
author_sort	Mohd Salleh, Faiqa Shazeaa
title	Compaction characteristics of Ficus Deltoidea jack extract powder
title_short	Compaction characteristics of Ficus Deltoidea jack extract powder
title_full	Compaction characteristics of Ficus Deltoidea jack extract powder
title_fullStr	Compaction characteristics of Ficus Deltoidea jack extract powder
title_full_unstemmed	Compaction characteristics of Ficus Deltoidea jack extract powder
title_sort	compaction characteristics of ficus deltoidea jack extract powder
granting_institution	Universiti Putra Malaysia
publishDate	2012
url	http://psasir.upm.edu.my/id/eprint/59776/7/FK%202012%20103IR.pdf
_version_	1747812250578583552

Compaction characteristics of Ficus Deltoidea jack extract powder

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