Anti-Inflammatory and Antinociceptive Properties of three Local Channa Species Crude Extracts
Water extract and aqueous portion of chloroform:methanol extract of Channu striatus (haruan), Channa micropeltes (toman) and Channa luciw (bujuk) wcre tested for its anti-inflammatory and antinociceptive properties. The anti-inflammatory activity of the extracts was investigated by three chemical...
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my-upm-ir.63732023-10-25T08:06:29Z Anti-Inflammatory and Antinociceptive Properties of three Local Channa Species Crude Extracts 2005-02 Mohd Hasan, Solihah Water extract and aqueous portion of chloroform:methanol extract of Channu striatus (haruan), Channa micropeltes (toman) and Channa luciw (bujuk) wcre tested for its anti-inflammatory and antinociceptive properties. The anti-inflammatory activity of the extracts was investigated by three chemical mediators induced rat paw edema (acute inflammation) and cotton pellet granuloma in rats (chronic inflammatory modulation testing). The antinociceptive or analgesic properties were investigated by abdominal constriction test and hot plate test. The results showed that the percentage edema inhibition increased with increased in time interval and was found to be maximal at 4 hours after prostaglandin D2 injection. The effects of 60 mgkg body weight aqueous portion of chloroform:methanol extract of Channa lucius and Channa micropeltes, piroxicam (10 mg/kg) and water extract of Channa striatus (60 mg/kg) exhibited 85.4%, 79.8%, 84.3% and 78.7% edema inhibition at 4 hours respectively. However, all three local Channa spp. extracts did not show significant inhibition (p>0.05) on histamine and bradykinin induced paw edema. In the cotton pellet induced granuloma, the percentage inhibition of anti- transudative was significantly different (p<0.05) by the water extract of Channa striatus (38.1%) and Channa micropelfes (30.3%) compared to the water extract of Channa lucius (10.8%) in inhibiting wet weight of the cotton pelletinduced granuloma formation in rats. Piroxicam showed significant inhibition (p<0.05) by 30.92% and mefenamic acid (13.28%) in inhibiting wet weight granuloma. The water extract of Channa striatus and Channa micropelfes exhibited anti-transudative activity but Channa lucius was devoid of this property. Both extracts of three local Channa spp. did not show anti-proliferative activity. The aqueous portion of chloroform:methanol extract of Channa striatus (60 mglkg) and mefenamic acid (10 mg/kg) increased the serum albumin levels at 24.83 * 4.09 g/dL and 24.83 * 4.30 g/dL respectively. The water extract of Channa striatus (30 mglkg) and the aqueous portion of chloroform:methanol extract Channa lucius (1 5 mg/kg) produced antinociceptive effect on acetic acid induced abdominal constriction test. However both extracts of three local Channa spp. failed to exhibit antinociceptive effect on hot plate test. As a reference drug, the administration of morphine (0.6 mg/kg) caused significant inhibition (p<0.05) by 99.3% in acetic acid induced abdominal constriction and 5 mg/kg of morphine produced significant increased the latency time in hot plate test when compared to control and both extracts of three local Channa spp. In conclusion, this study showed that Channa striatus extracts has more potent the anti-inflammatory and antinociceptive activities compared to the other closely related snakehead fish Channa micropelfes and Channa lucius. The extracts from Channa striafus have the potential being the antiinflammatory and antinociceptive agents. 2005-02 Thesis http://psasir.upm.edu.my/id/eprint/6373/ http://psasir.upm.edu.my/id/eprint/6373/1/FPSK%28M%29_2005_24.pdf text en public masters Universiti Putra Malaysia Faculty Medicine and Health Sciences English |
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Mohd Hasan, Solihah Anti-Inflammatory and Antinociceptive Properties of three Local Channa Species Crude Extracts |
| description |
Water extract and aqueous portion of chloroform:methanol extract of Channu striatus
(haruan), Channa micropeltes (toman) and Channa luciw (bujuk) wcre tested for its
anti-inflammatory and antinociceptive properties. The anti-inflammatory activity of the
extracts was investigated by three chemical mediators induced rat paw edema (acute
inflammation) and cotton pellet granuloma in rats (chronic inflammatory modulation
testing). The antinociceptive or analgesic properties were investigated by abdominal
constriction test and hot plate test. The results showed that the percentage edema
inhibition increased with increased in time interval and was found to be maximal at 4
hours after prostaglandin D2 injection. The effects of 60 mgkg body weight aqueous
portion of chloroform:methanol extract of Channa lucius and Channa micropeltes,
piroxicam (10 mg/kg) and water extract of Channa striatus (60 mg/kg) exhibited 85.4%,
79.8%, 84.3% and 78.7% edema inhibition at 4 hours respectively. However, all three
local Channa spp. extracts did not show significant inhibition (p>0.05) on histamine
and bradykinin induced paw edema. In the cotton pellet induced granuloma, the
percentage inhibition of anti- transudative was significantly different (p<0.05) by the
water extract of Channa striatus (38.1%) and Channa micropelfes (30.3%) compared to
the water extract of Channa lucius (10.8%) in inhibiting wet weight of the cotton pelletinduced
granuloma formation in rats. Piroxicam showed significant inhibition (p<0.05)
by 30.92% and mefenamic acid (13.28%) in inhibiting wet weight granuloma. The water
extract of Channa striatus and Channa micropelfes exhibited anti-transudative activity
but Channa lucius was devoid of this property. Both extracts of three local Channa spp.
did not show anti-proliferative activity. The aqueous portion of chloroform:methanol
extract of Channa striatus (60 mglkg) and mefenamic acid (10 mg/kg) increased the
serum albumin levels at 24.83 * 4.09 g/dL and 24.83 * 4.30 g/dL respectively. The
water extract of Channa striatus (30 mglkg) and the aqueous portion of
chloroform:methanol extract Channa lucius (1 5 mg/kg) produced antinociceptive effect
on acetic acid induced abdominal constriction test. However both extracts of three local
Channa spp. failed to exhibit antinociceptive effect on hot plate test. As a reference
drug, the administration of morphine (0.6 mg/kg) caused significant inhibition (p<0.05)
by 99.3% in acetic acid induced abdominal constriction and 5 mg/kg of morphine
produced significant increased the latency time in hot plate test when compared to
control and both extracts of three local Channa spp. In conclusion, this study showed
that Channa striatus extracts has more potent the anti-inflammatory and antinociceptive
activities compared to the other closely related snakehead fish Channa micropelfes and
Channa lucius. The extracts from Channa striafus have the potential being the antiinflammatory
and antinociceptive agents. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Mohd Hasan, Solihah |
| author_facet |
Mohd Hasan, Solihah |
| author_sort |
Mohd Hasan, Solihah |
| title |
Anti-Inflammatory and Antinociceptive Properties of three Local Channa Species Crude Extracts |
| title_short |
Anti-Inflammatory and Antinociceptive Properties of three Local Channa Species Crude Extracts |
| title_full |
Anti-Inflammatory and Antinociceptive Properties of three Local Channa Species Crude Extracts |
| title_fullStr |
Anti-Inflammatory and Antinociceptive Properties of three Local Channa Species Crude Extracts |
| title_full_unstemmed |
Anti-Inflammatory and Antinociceptive Properties of three Local Channa Species Crude Extracts |
| title_sort |
anti-inflammatory and antinociceptive properties of three local channa species crude extracts |
| granting_institution |
Universiti Putra Malaysia |
| granting_department |
Faculty Medicine and Health Sciences |
| publishDate |
2005 |
| url |
http://psasir.upm.edu.my/id/eprint/6373/1/FPSK%28M%29_2005_24.pdf |
| _version_ |
1783725738581557248 |