Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties
Previously, andrographolide, which is the major diterpenoid of Andrographis paniculata, was shown to have in vivo antitumour activity against human breast tumour xenografts. In this study, among the four compounds isolated from A. paniculata, andrographolide was the most potent compound with a me...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English English |
| Published: |
2004
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/6584/1/FPSK%28P%29_2004_8.pdf |
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| Summary: | Previously, andrographolide, which is the major diterpenoid of Andrographis
paniculata, was shown to have in vivo antitumour activity against human breast tumour
xenografts. In this study, among the four compounds isolated from A. paniculata,
andrographolide was the most potent compound with a mean ICso value of 8 IlM in
MCF-7 human breast cancer cells. Neoandrographolide showed a weak cytotoxic effect,
whereas 14-deoxy-ll, 12-didehydroandrographolide and 14-deoxyandrographolide failed
to exhibit growth inhibitory effect at the highest tested concentration of 100 IlM. Owing
to this, andrographolide was considered as the lead compound in the discovery of potent
and selective antitumour agents.
Using andrographolide isolated from A. paniculata as one of the starting materials, 3,19- |
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