Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties

Previously, andrographolide, which is the major diterpenoid of Andrographis paniculata, was shown to have in vivo antitumour activity against human breast tumour xenografts. In this study, among the four compounds isolated from A. paniculata, andrographolide was the most potent compound with a me...

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Main Author:	Rao, Jada Srinivasa
Format:	Thesis
Language:	English English
Published:	2004
Subjects:
Online Access:	http://psasir.upm.edu.my/id/eprint/6584/1/FPSK%28P%29_2004_8.pdf
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id	my-upm-ir.6584
record_format	uketd_dc
spelling	my-upm-ir.65842023-11-02T07:36:57Z Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties 2004-10 Rao, Jada Srinivasa Previously, andrographolide, which is the major diterpenoid of Andrographis paniculata, was shown to have in vivo antitumour activity against human breast tumour xenografts. In this study, among the four compounds isolated from A. paniculata, andrographolide was the most potent compound with a mean ICso value of 8 IlM in MCF-7 human breast cancer cells. Neoandrographolide showed a weak cytotoxic effect, whereas 14-deoxy-ll, 12-didehydroandrographolide and 14-deoxyandrographolide failed to exhibit growth inhibitory effect at the highest tested concentration of 100 IlM. Owing to this, andrographolide was considered as the lead compound in the discovery of potent and selective antitumour agents. Using andrographolide isolated from A. paniculata as one of the starting materials, 3,19- 2004-10 Thesis http://psasir.upm.edu.my/id/eprint/6584/ http://psasir.upm.edu.my/id/eprint/6584/1/FPSK%28P%29_2004_8.pdf text en public doctoral Universiti Putra Malaysia Faculty Medicine and Health Sciences Abdul Aziz, Nasaruddin English
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English English
advisor	Abdul Aziz, Nasaruddin
topic
spellingShingle	Rao, Jada Srinivasa Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties
description	Previously, andrographolide, which is the major diterpenoid of Andrographis paniculata, was shown to have in vivo antitumour activity against human breast tumour xenografts. In this study, among the four compounds isolated from A. paniculata, andrographolide was the most potent compound with a mean ICso value of 8 IlM in MCF-7 human breast cancer cells. Neoandrographolide showed a weak cytotoxic effect, whereas 14-deoxy-ll, 12-didehydroandrographolide and 14-deoxyandrographolide failed to exhibit growth inhibitory effect at the highest tested concentration of 100 IlM. Owing to this, andrographolide was considered as the lead compound in the discovery of potent and selective antitumour agents. Using andrographolide isolated from A. paniculata as one of the starting materials, 3,19-
format	Thesis
qualification_level	Doctorate
author	Rao, Jada Srinivasa
author_facet	Rao, Jada Srinivasa
author_sort	Rao, Jada Srinivasa
title	Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties
title_short	Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties
title_full	Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties
title_fullStr	Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties
title_full_unstemmed	Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties
title_sort	semisynthesis of andrographolide derivatives and evaluation of their antitumour properties
granting_institution	Universiti Putra Malaysia
granting_department	Faculty Medicine and Health Sciences
publishDate	2004
url	http://psasir.upm.edu.my/id/eprint/6584/1/FPSK%28P%29_2004_8.pdf
_version_	1783725763548151808

Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties

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