Comparison of Ephedrine and Dopamine to Manage Hypotension and Assessment of Arterial Pressure Waveform Analysis to Monitor Cardiac Ouput in Dogs Under Isoflurane Anesthesia

Comparison of Ephedrine and Dopamine to Manage Hypotension and Assessment of Arterial Pressure Waveform Analysis to Monitor Cardiac Ouput in Dogs Under Isoflurane Anesthesia

The first study compared the cardiovascular responses of ephedrine at 0.2 mg/kg, IV (doubled to 10µg/kg/min, IV, if inadequate response) to manage hypotension in clinical canine cases during routine anesthetic management. Treatments were randomly assigned to treat hypotension (mean arterial pressure...

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Main Author: Hui, Cheng Chen
Format: Thesis
Language:English
English
Published: 2004
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Online Access:http://psasir.upm.edu.my/id/eprint/6589/1/FPV_2004_23%281-24%29.pdf
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spelling my-upm-ir.65892013-05-27T07:30:28Z Comparison of Ephedrine and Dopamine to Manage Hypotension and Assessment of Arterial Pressure Waveform Analysis to Monitor Cardiac Ouput in Dogs Under Isoflurane Anesthesia 2004-09 Hui, Cheng Chen The first study compared the cardiovascular responses of ephedrine at 0.2 mg/kg, IV (doubled to 10µg/kg/min, IV, if inadequate response) to manage hypotension in clinical canine cases during routine anesthetic management. Treatments were randomly assigned to treat hypotension (mean arterial pressure, MAP < 60 mm Hg) in 12 cases. When MAP remained lower than 70 mm Hg at 10 minutes post treatment, the ephedrine bolus was repeated or the dopamine infusion was doubled. The pressure-elevating effect of ephedrine was found to last less than 5 minutes, with improvement in cardiac index (CI), stroke volume index (SVI) and oxygen delivery index (DO2I), but a decrease in systematic vascular resistance (SVR) at 10 minutes. Repeating the ephedrine did not produce further improvement. The infusion of dopamine at 5µg/kg/min did not improve blood pressure (BP), CI, DO2I or SVI within 10 minutes. Increasing the infusion to 10µg/kg/min improved BP within 5 minutes, and increased CI, DO2I and SVI by 10 minutes. The ephedrine boluses were less effective than the dopamine infusions to augment BP, but the improvement in CI, DO2I and SVI by the end of the 20 minute study period was not different between treatments. 2004-09 Thesis http://psasir.upm.edu.my/id/eprint/6589/ http://psasir.upm.edu.my/id/eprint/6589/1/FPV_2004_23%281-24%29.pdf application/pdf en public phd doctoral Universiti Putra Malaysia Faculty of Veterinary Medicine English
institution Universiti Putra Malaysia
collection PSAS Institutional Repository
language English
English
topic


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Hui, Cheng Chen
Comparison of Ephedrine and Dopamine to Manage Hypotension and Assessment of Arterial Pressure Waveform Analysis to Monitor Cardiac Ouput in Dogs Under Isoflurane Anesthesia
description The first study compared the cardiovascular responses of ephedrine at 0.2 mg/kg, IV (doubled to 10µg/kg/min, IV, if inadequate response) to manage hypotension in clinical canine cases during routine anesthetic management. Treatments were randomly assigned to treat hypotension (mean arterial pressure, MAP < 60 mm Hg) in 12 cases. When MAP remained lower than 70 mm Hg at 10 minutes post treatment, the ephedrine bolus was repeated or the dopamine infusion was doubled. The pressure-elevating effect of ephedrine was found to last less than 5 minutes, with improvement in cardiac index (CI), stroke volume index (SVI) and oxygen delivery index (DO2I), but a decrease in systematic vascular resistance (SVR) at 10 minutes. Repeating the ephedrine did not produce further improvement. The infusion of dopamine at 5µg/kg/min did not improve blood pressure (BP), CI, DO2I or SVI within 10 minutes. Increasing the infusion to 10µg/kg/min improved BP within 5 minutes, and increased CI, DO2I and SVI by 10 minutes. The ephedrine boluses were less effective than the dopamine infusions to augment BP, but the improvement in CI, DO2I and SVI by the end of the 20 minute study period was not different between treatments.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Hui, Cheng Chen
author_facet Hui, Cheng Chen
author_sort Hui, Cheng Chen
title Comparison of Ephedrine and Dopamine to Manage Hypotension and Assessment of Arterial Pressure Waveform Analysis to Monitor Cardiac Ouput in Dogs Under Isoflurane Anesthesia
title_short Comparison of Ephedrine and Dopamine to Manage Hypotension and Assessment of Arterial Pressure Waveform Analysis to Monitor Cardiac Ouput in Dogs Under Isoflurane Anesthesia
title_full Comparison of Ephedrine and Dopamine to Manage Hypotension and Assessment of Arterial Pressure Waveform Analysis to Monitor Cardiac Ouput in Dogs Under Isoflurane Anesthesia
title_fullStr Comparison of Ephedrine and Dopamine to Manage Hypotension and Assessment of Arterial Pressure Waveform Analysis to Monitor Cardiac Ouput in Dogs Under Isoflurane Anesthesia
title_full_unstemmed Comparison of Ephedrine and Dopamine to Manage Hypotension and Assessment of Arterial Pressure Waveform Analysis to Monitor Cardiac Ouput in Dogs Under Isoflurane Anesthesia
title_sort comparison of ephedrine and dopamine to manage hypotension and assessment of arterial pressure waveform analysis to monitor cardiac ouput in dogs under isoflurane anesthesia
granting_institution Universiti Putra Malaysia
granting_department Faculty of Veterinary Medicine
publishDate 2004
url http://psasir.upm.edu.my/id/eprint/6589/1/FPV_2004_23%281-24%29.pdf
_version_ 1747810632310194176

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