Synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes

Three new Schiff bases were synthesized from the condensation reaction of S-benzyldithiocarbazate (SBDTC) with acetylferrocene, and S-4-methylbenzyldithiocarbazate (S4MBDTC) with S-camphorquinone and R-camphorquinone. A series of fifteen metal complexes were successfully synthesized from the react...

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Main Author:	Elhassan, Hiba Hayder Hanza
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Schiff bases Metal complexes
Online Access:	http://psasir.upm.edu.my/id/eprint/67141/1/FS%202012%2097%20IR.pdf
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id	my-upm-ir.67141
record_format	uketd_dc
spelling	my-upm-ir.671412019-02-20T07:57:23Z Synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes 2012-12 Elhassan, Hiba Hayder Hanza Three new Schiff bases were synthesized from the condensation reaction of S-benzyldithiocarbazate (SBDTC) with acetylferrocene, and S-4-methylbenzyldithiocarbazate (S4MBDTC) with S-camphorquinone and R-camphorquinone. A series of fifteen metal complexes were successfully synthesized from the reaction of the Schiff bases with metal salts of Cobalt(II), Nickel(II), Cadmium(II), Copper(II), and Zinc(II). All the compounds were characterized using various physio-chemical and spectroscopic techniques. Two structures were determined using X-ray diffraction analysis. The crystal structure of Ni(II) complex of camphorquinone and S-4-methylbenzyldithiocarbazate showed that the complex exhibited a six coordinate octahedral geometry. The Schiff base acted as a uninegatively charged tridentate ligand coordinating to the Ni(II) ion via the azomethine nitrogen atom, thiolate sulfur atom, and carbonyl oxygen atom. Unfortunately, attempts to grow crystals of the other metal complexes were not successful. These newly synthesized compounds exhibited significant cytotoxic activities towards MCF-7 (Human breast carcinoma cells with positive estrogen receptors) and MDA-MB-231 (Human breast carcinoma cells with negative estrogen receptors). Schiff bases were found to be more active towards the tested cancer cells than their metal complexes. Schiff bases Metal complexes 2012-12 Thesis http://psasir.upm.edu.my/id/eprint/67141/ http://psasir.upm.edu.my/id/eprint/67141/1/FS%202012%2097%20IR.pdf text en public masters Universiti Putra Malaysia Schiff bases Metal complexes
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Schiff bases Metal complexes
spellingShingle	Schiff bases Metal complexes Elhassan, Hiba Hayder Hanza Synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes
description	Three new Schiff bases were synthesized from the condensation reaction of S-benzyldithiocarbazate (SBDTC) with acetylferrocene, and S-4-methylbenzyldithiocarbazate (S4MBDTC) with S-camphorquinone and R-camphorquinone. A series of fifteen metal complexes were successfully synthesized from the reaction of the Schiff bases with metal salts of Cobalt(II), Nickel(II), Cadmium(II), Copper(II), and Zinc(II). All the compounds were characterized using various physio-chemical and spectroscopic techniques. Two structures were determined using X-ray diffraction analysis. The crystal structure of Ni(II) complex of camphorquinone and S-4-methylbenzyldithiocarbazate showed that the complex exhibited a six coordinate octahedral geometry. The Schiff base acted as a uninegatively charged tridentate ligand coordinating to the Ni(II) ion via the azomethine nitrogen atom, thiolate sulfur atom, and carbonyl oxygen atom. Unfortunately, attempts to grow crystals of the other metal complexes were not successful. These newly synthesized compounds exhibited significant cytotoxic activities towards MCF-7 (Human breast carcinoma cells with positive estrogen receptors) and MDA-MB-231 (Human breast carcinoma cells with negative estrogen receptors). Schiff bases were found to be more active towards the tested cancer cells than their metal complexes.
format	Thesis
qualification_level	Master's degree
author	Elhassan, Hiba Hayder Hanza
author_facet	Elhassan, Hiba Hayder Hanza
author_sort	Elhassan, Hiba Hayder Hanza
title	Synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes
title_short	Synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes
title_full	Synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes
title_fullStr	Synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes
title_full_unstemmed	Synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes
title_sort	synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes
granting_institution	Universiti Putra Malaysia
publishDate	2012
url	http://psasir.upm.edu.my/id/eprint/67141/1/FS%202012%2097%20IR.pdf
_version_	1747812446471454720

Synthesis, characterization and biological activities of dithiocarbazate nitrogen sulfur donor ligands and their metal complexes

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