Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action

The objective of the present study is to evaluate the antinociceptive activity of the new chalcone derivative, the 3-(2,3 dimethoxyphenyl)-1 (methylfuran-2-yl) prop-2- en-1-one (DMPF), using the chemical- and thermal-induced nociception test together with the mechanisms of actions. It was demo...

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Main Author:	Ismail, Nur Izzati
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Chalcones - biosynthesis Chalcones - toxicity Chalcones - adverse effects
Online Access:	http://psasir.upm.edu.my/id/eprint/67634/1/FPSK%202015%2076%20IR.pdf
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id	my-upm-ir.67634
record_format	uketd_dc
spelling	my-upm-ir.676342019-03-18T06:58:21Z Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action 2015-02 Ismail, Nur Izzati The objective of the present study is to evaluate the antinociceptive activity of the new chalcone derivative, the 3-(2,3 dimethoxyphenyl)-1 (methylfuran-2-yl) prop-2- en-1-one (DMPF), using the chemical- and thermal-induced nociception test together with the mechanisms of actions. It was demonstrated that, administration of DMPF given by the i.p route produced a significant dose-dependent inhibition on acetic acidinduced writhing test, increased in response latency time for the hot plate test and reduction in time spent licking the injected paw for both neurogenic and inflammatory phases in formalin-induced paw licking test. Furthermore, the antinociceptive effect of DMPF in the acetic acid-induced writhing and the hot plate test was not reversed by non-selective opioid receptor antagonist, naloxone, that shown the non-involvement of the opioidergic system in antinociceptive activity of DPMF. Contrarily, administration of DMPF produced significant dose-dependent inhibition in capsaicin-induced paw licking test, glutamate-induced paw licking test, and PMA-induced paw licking test proven the involvement of TRPV1 receptor, glutamatergic system and PKC system. Antinociception caused by DPMF in the acetic acid test reversed the treatment with LNOARG (nitric oxide synthase inhibitor) and charybdotoxin (a large-conductance ca2+-sensitive K+ channels blocker). However, antinociception of DPMF was enhanced by ODQ (a specific guanylyl cyclase inhibitor). To sum up, the results indicate that DPMF produced pronounced central and peripheral antinociception by inhibition on glutamate receptors, TRPV1 receptors and protein kinase C. It is also strongly suggested that the L-arginine/NO/cGMP/BKca channel pathway plays a significant role in DPMF-induced antinociception. Chalcones - biosynthesis Chalcones - toxicity Chalcones - adverse effects 2015-02 Thesis http://psasir.upm.edu.my/id/eprint/67634/ http://psasir.upm.edu.my/id/eprint/67634/1/FPSK%202015%2076%20IR.pdf text en public masters Universiti Putra Malaysia Chalcones - biosynthesis Chalcones - toxicity Chalcones - adverse effects
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Chalcones - biosynthesis Chalcones - toxicity Chalcones - adverse effects
spellingShingle	Chalcones - biosynthesis Chalcones - toxicity Chalcones - adverse effects Ismail, Nur Izzati Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action
description	The objective of the present study is to evaluate the antinociceptive activity of the new chalcone derivative, the 3-(2,3 dimethoxyphenyl)-1 (methylfuran-2-yl) prop-2- en-1-one (DMPF), using the chemical- and thermal-induced nociception test together with the mechanisms of actions. It was demonstrated that, administration of DMPF given by the i.p route produced a significant dose-dependent inhibition on acetic acidinduced writhing test, increased in response latency time for the hot plate test and reduction in time spent licking the injected paw for both neurogenic and inflammatory phases in formalin-induced paw licking test. Furthermore, the antinociceptive effect of DMPF in the acetic acid-induced writhing and the hot plate test was not reversed by non-selective opioid receptor antagonist, naloxone, that shown the non-involvement of the opioidergic system in antinociceptive activity of DPMF. Contrarily, administration of DMPF produced significant dose-dependent inhibition in capsaicin-induced paw licking test, glutamate-induced paw licking test, and PMA-induced paw licking test proven the involvement of TRPV1 receptor, glutamatergic system and PKC system. Antinociception caused by DPMF in the acetic acid test reversed the treatment with LNOARG (nitric oxide synthase inhibitor) and charybdotoxin (a large-conductance ca2+-sensitive K+ channels blocker). However, antinociception of DPMF was enhanced by ODQ (a specific guanylyl cyclase inhibitor). To sum up, the results indicate that DPMF produced pronounced central and peripheral antinociception by inhibition on glutamate receptors, TRPV1 receptors and protein kinase C. It is also strongly suggested that the L-arginine/NO/cGMP/BKca channel pathway plays a significant role in DPMF-induced antinociception.
format	Thesis
qualification_level	Master's degree
author	Ismail, Nur Izzati
author_facet	Ismail, Nur Izzati
author_sort	Ismail, Nur Izzati
title	Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action
title_short	Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action
title_full	Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action
title_fullStr	Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action
title_full_unstemmed	Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action
title_sort	antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action
granting_institution	Universiti Putra Malaysia
publishDate	2015
url	http://psasir.upm.edu.my/id/eprint/67634/1/FPSK%202015%2076%20IR.pdf
_version_	1747812492125405184

Antinociceptive effect of 3-(2, 3 dimethoxyphenyl)-1(methylfuran-2-yl) prop-2-en-1-one in mice and its mechanisms of action

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