Preparation and bioactivities of Cu(II) and Ni(II) complexes containing amino acid-derived schiff bases

There is an urgent need to discover new drugs with enhanced activity, selectivity, bioavailability and fewer side effects than the current drug regime. In view of this, metal complexes containing amino acid-derived Schiff bases with potentially exciting biological activities and coordination chemist...

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Main Author:	Abas, Nur Fatihah
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Metal complexes - Analysis Schiff bases Copper
Online Access:	http://psasir.upm.edu.my/id/eprint/68668/1/FS%202018%2018%20-%20IR.pdf
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spelling	my-upm-ir.686682019-05-31T00:48:42Z Preparation and bioactivities of Cu(II) and Ni(II) complexes containing amino acid-derived schiff bases 2017-12 Abas, Nur Fatihah There is an urgent need to discover new drugs with enhanced activity, selectivity, bioavailability and fewer side effects than the current drug regime. In view of this, metal complexes containing amino acid-derived Schiff bases with potentially exciting biological activities and coordination chemistry are attractive candidates for consideration. The research reported in this thesis focused on synthesis and characterisation of new metal complexes containing amino acid-derived Schiff base. Thirty new metal complexes were synthesised from the reaction of Cu(II) chloride and Ni(II) acetate with Schiff bases derived from the condensation of amino acids (L-phenylalanine (P), L-valine (V), L-histidine (H), L-cysteine (C) and L-methionine (M) ) and different ketones (2-acetylpyrazine (2APZ), 2-acetylpyridine (2APD) and 2-benzoylpyridine (2BPD)). The synthesised complexes were characterised by various techniques including elemental analysis, molar conductance, magnetic measurements, IR, electronic spectroscopy and thermal analysis. The data obtained indicated that the amino acid-derived Schiff bases behaved as uninegatively charged tridentate NNO ligands and coordinated with the Cu(II) and Ni(II) ions via azomethine nitrogen, pyridine/pyrazine nitrogen and deprotonated carboxylate oxygen yielding stable metal complexes as evidenced in their IR Spectra. In the Cu(II) complexes, only one tridentate amino acid-derived Schiff bases was coordinated to the metal centre, while the fourth position was occupied by chloride ion. In most of the Ni(II) complexes, only one tridentate amino acid-derived Schiff bases was coordinated to the metal centre, while the fourth position was occupied by acetate ion except for [Ni(H2APZ)2].H2O, [Ni(M2APZ)2] and [Ni(M2BPD)2] complexes where they had two tridentate NNO amino acid-derived Schiff bases bonded to the metal centre. Magnetic measurements and spectral evidence supported a four coordinate geometry for Cu(II) complexes and four/six coordinate geometry for the Ni(II) complexes. The thermal analysis proved the presence of water molecules outside the coordination sphere of some of the metal complexes synthesised. The newly synthesised complexes have been screened for activity against two bladder cancer cell lines which are the invasive human bladder carcinoma cell line, EJ-28 and the minimum invasive human bladder carcinoma cell line, RT-112. It was found that the Cu(II) complexes had better cytotoxic activity against EJ-28 cells compared to RT-112 cells. In general, the Cu(II) and Ni(II) complexes containing amino acid-derived Schiff bases displayed a wide range of activity from non-active to active and could be promising candidates for selective and specific anticancer activity. Metal complexes - Analysis Schiff bases Copper 2017-12 Thesis http://psasir.upm.edu.my/id/eprint/68668/ http://psasir.upm.edu.my/id/eprint/68668/1/FS%202018%2018%20-%20IR.pdf text en public masters Universiti Putra Malaysia Metal complexes - Analysis Schiff bases Copper
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Metal complexes - Analysis Schiff bases Copper
spellingShingle	Metal complexes - Analysis Schiff bases Copper Abas, Nur Fatihah Preparation and bioactivities of Cu(II) and Ni(II) complexes containing amino acid-derived schiff bases
description	There is an urgent need to discover new drugs with enhanced activity, selectivity, bioavailability and fewer side effects than the current drug regime. In view of this, metal complexes containing amino acid-derived Schiff bases with potentially exciting biological activities and coordination chemistry are attractive candidates for consideration. The research reported in this thesis focused on synthesis and characterisation of new metal complexes containing amino acid-derived Schiff base. Thirty new metal complexes were synthesised from the reaction of Cu(II) chloride and Ni(II) acetate with Schiff bases derived from the condensation of amino acids (L-phenylalanine (P), L-valine (V), L-histidine (H), L-cysteine (C) and L-methionine (M) ) and different ketones (2-acetylpyrazine (2APZ), 2-acetylpyridine (2APD) and 2-benzoylpyridine (2BPD)). The synthesised complexes were characterised by various techniques including elemental analysis, molar conductance, magnetic measurements, IR, electronic spectroscopy and thermal analysis. The data obtained indicated that the amino acid-derived Schiff bases behaved as uninegatively charged tridentate NNO ligands and coordinated with the Cu(II) and Ni(II) ions via azomethine nitrogen, pyridine/pyrazine nitrogen and deprotonated carboxylate oxygen yielding stable metal complexes as evidenced in their IR Spectra. In the Cu(II) complexes, only one tridentate amino acid-derived Schiff bases was coordinated to the metal centre, while the fourth position was occupied by chloride ion. In most of the Ni(II) complexes, only one tridentate amino acid-derived Schiff bases was coordinated to the metal centre, while the fourth position was occupied by acetate ion except for [Ni(H2APZ)2].H2O, [Ni(M2APZ)2] and [Ni(M2BPD)2] complexes where they had two tridentate NNO amino acid-derived Schiff bases bonded to the metal centre. Magnetic measurements and spectral evidence supported a four coordinate geometry for Cu(II) complexes and four/six coordinate geometry for the Ni(II) complexes. The thermal analysis proved the presence of water molecules outside the coordination sphere of some of the metal complexes synthesised. The newly synthesised complexes have been screened for activity against two bladder cancer cell lines which are the invasive human bladder carcinoma cell line, EJ-28 and the minimum invasive human bladder carcinoma cell line, RT-112. It was found that the Cu(II) complexes had better cytotoxic activity against EJ-28 cells compared to RT-112 cells. In general, the Cu(II) and Ni(II) complexes containing amino acid-derived Schiff bases displayed a wide range of activity from non-active to active and could be promising candidates for selective and specific anticancer activity.
format	Thesis
qualification_level	Master's degree
author	Abas, Nur Fatihah
author_facet	Abas, Nur Fatihah
author_sort	Abas, Nur Fatihah
title	Preparation and bioactivities of Cu(II) and Ni(II) complexes containing amino acid-derived schiff bases
title_short	Preparation and bioactivities of Cu(II) and Ni(II) complexes containing amino acid-derived schiff bases
title_full	Preparation and bioactivities of Cu(II) and Ni(II) complexes containing amino acid-derived schiff bases
title_fullStr	Preparation and bioactivities of Cu(II) and Ni(II) complexes containing amino acid-derived schiff bases
title_full_unstemmed	Preparation and bioactivities of Cu(II) and Ni(II) complexes containing amino acid-derived schiff bases
title_sort	preparation and bioactivities of cu(ii) and ni(ii) complexes containing amino acid-derived schiff bases
granting_institution	Universiti Putra Malaysia
publishDate	2017
url	http://psasir.upm.edu.my/id/eprint/68668/1/FS%202018%2018%20-%20IR.pdf
_version_	1747812615992639488

Preparation and bioactivities of Cu(II) and Ni(II) complexes containing amino acid-derived schiff bases

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