Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases

Thirty new metal complexes were synthesized from the reaction of Cu(II) acetate and Ni(II) nitrate with Schiff bases derived from the condensation of amino acids (Lphenylalanine, L-valine and glycine) and different heterocyclic aldehydes and ketones. The complexes were characterized by elemental...

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Main Author:	Abdul Aziz, Nur Fadhilah
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Antibody-dependent cell cytotoxicity Amino acids
Online Access:	http://psasir.upm.edu.my/id/eprint/69275/1/FS%202016%2068%20IR.pdf
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id	my-upm-ir.69275
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spelling	my-upm-ir.692752019-06-27T01:44:21Z Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases 2016-11 Abdul Aziz, Nur Fadhilah Thirty new metal complexes were synthesized from the reaction of Cu(II) acetate and Ni(II) nitrate with Schiff bases derived from the condensation of amino acids (Lphenylalanine, L-valine and glycine) and different heterocyclic aldehydes and ketones. The complexes were characterized by elemental analysis and conductance, magnetic, IR and electronic spectroscopic measurements. The data obtained indicated that the amino acid derived Schiff bases behaved as uninegatively charged bidentate ligands and coordinated with the Cu(II) and Ni(II) ions through their azomethine nitrogen and the deprotonated carboxylate oxygen yielding stable metal complexes as evidenced in their IR spectra. In most of the Cu(II) complexes, only one amino acid derived Schiff base coordinated to the metal centre, while the third and fourth position were occupied by a bidentate -OO- acetate anion. Whereas in two other Cu(II) complexes ([Cu(ph3t)2].H2O (Cu(II) complex of 2-[(3-methylthiophene- 2-ylmethylene)-amino]-3-phenyl-propionic acid) and [Cu(glypy)2].5H2O (Cu(II) complex of [1-(1H-Pyrrol-2-yl)-ethylideneamino]-acetic acid)) and all the Ni(II) complexes, two bidentate -ON- amino acid derived Schiff bases were bonded to the metal centre. Magnetic and spectral evidence supported a four-coordinate geometry for all complexes synthesized. The thermal analysis studies proved the presence of water molecules and methanol outside the inner coordination sphere of some of the complexes synthesized. In turn, the cytotoxic activities of the metal complexes were evaluated against two bladder cancer cell lines which are EJ-28 (invasive human bladder cancer cell line) and RT-112 (minimally-invasive human bladder cancer cell line) and ten of the Ni(II) complexes showed remarkable cytotoxicity against EJ-28 cells while six of the Cu(II) complexes were found to be cytotoxic against RT-112 cells. In conclusion, it appeared that the complexes derived from glycine and 2- acetylpyrrole as their ligands had the best cytotoxic activity in both cancer cell lines. Antibody-dependent cell cytotoxicity Amino acids 2016-11 Thesis http://psasir.upm.edu.my/id/eprint/69275/ http://psasir.upm.edu.my/id/eprint/69275/1/FS%202016%2068%20IR.pdf text en public masters Universiti Putra Malaysia Antibody-dependent cell cytotoxicity Amino acids
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Antibody-dependent cell cytotoxicity Amino acids
spellingShingle	Antibody-dependent cell cytotoxicity Amino acids Abdul Aziz, Nur Fadhilah Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases
description	Thirty new metal complexes were synthesized from the reaction of Cu(II) acetate and Ni(II) nitrate with Schiff bases derived from the condensation of amino acids (Lphenylalanine, L-valine and glycine) and different heterocyclic aldehydes and ketones. The complexes were characterized by elemental analysis and conductance, magnetic, IR and electronic spectroscopic measurements. The data obtained indicated that the amino acid derived Schiff bases behaved as uninegatively charged bidentate ligands and coordinated with the Cu(II) and Ni(II) ions through their azomethine nitrogen and the deprotonated carboxylate oxygen yielding stable metal complexes as evidenced in their IR spectra. In most of the Cu(II) complexes, only one amino acid derived Schiff base coordinated to the metal centre, while the third and fourth position were occupied by a bidentate -OO- acetate anion. Whereas in two other Cu(II) complexes ([Cu(ph3t)2].H2O (Cu(II) complex of 2-[(3-methylthiophene- 2-ylmethylene)-amino]-3-phenyl-propionic acid) and [Cu(glypy)2].5H2O (Cu(II) complex of [1-(1H-Pyrrol-2-yl)-ethylideneamino]-acetic acid)) and all the Ni(II) complexes, two bidentate -ON- amino acid derived Schiff bases were bonded to the metal centre. Magnetic and spectral evidence supported a four-coordinate geometry for all complexes synthesized. The thermal analysis studies proved the presence of water molecules and methanol outside the inner coordination sphere of some of the complexes synthesized. In turn, the cytotoxic activities of the metal complexes were evaluated against two bladder cancer cell lines which are EJ-28 (invasive human bladder cancer cell line) and RT-112 (minimally-invasive human bladder cancer cell line) and ten of the Ni(II) complexes showed remarkable cytotoxicity against EJ-28 cells while six of the Cu(II) complexes were found to be cytotoxic against RT-112 cells. In conclusion, it appeared that the complexes derived from glycine and 2- acetylpyrrole as their ligands had the best cytotoxic activity in both cancer cell lines.
format	Thesis
qualification_level	Master's degree
author	Abdul Aziz, Nur Fadhilah
author_facet	Abdul Aziz, Nur Fadhilah
author_sort	Abdul Aziz, Nur Fadhilah
title	Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases
title_short	Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases
title_full	Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases
title_fullStr	Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases
title_full_unstemmed	Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases
title_sort	synthesis, characterization and cytotoxic study of cu(ii) and ni(ii) containing amino acid derived schiff bases
granting_institution	Universiti Putra Malaysia
publishDate	2016
url	http://psasir.upm.edu.my/id/eprint/69275/1/FS%202016%2068%20IR.pdf
_version_	1747812677374181376

Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases

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