Encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle

Cancer chemotherapy drugs are not specific on their metabolic pathways to the cancer cell. Therefore, there is a need to overcome this disadvantages by applying targeted drug delivery using composite nanoparticles. Similarly, tamoxifen citrate (TAM) also suffer from this disadvantages. TAM is a drug...

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Main Author:	Albert, Emmellie Laura
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Pharmaceutical technology Drugs - Coatings
Online Access:	http://psasir.upm.edu.my/id/eprint/69485/1/ITMA%202018%202%20-%20IR.pdf
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spelling	my-upm-ir.694852019-11-11T01:29:09Z Encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle 2017-05 Albert, Emmellie Laura Cancer chemotherapy drugs are not specific on their metabolic pathways to the cancer cell. Therefore, there is a need to overcome this disadvantages by applying targeted drug delivery using composite nanoparticles. Similarly, tamoxifen citrate (TAM) also suffer from this disadvantages. TAM is a drug used for breast cancer treatment. So, current investigations are proposing the usage of magnetite nanoparticles (MNP) as an anti-cancer drug carrier because of its biocompatibility, ultrafine size, and its superparamagnetic nature. In this study, poly (d,l-lactice-co-glycolide acid) (PLGA) were used to encapsulated both MNP and TAM to form a multifunctional nanoparticle which have both the superparamagnetic properties of MNP and therapeutic ability of TAM. MNP were synthesized via the co-precipitation method. Then, it was coated with oleic acid (OA) to reduce the aggregation and it was abbreviated as OAMNP. Formation of functionalized OAMNPs with TAM using PLGA (TAM-PLGA-OAMNP) was obtained by oil in water emulsion evaporation technique. The XRD pattern showed that crystalline phase of the MNP is inverse spinel cubic of Fe3O4. After modification, FTIR spectra revealed that the TAM were successfully encapsulated into the PLGA matrixes. By using TEM, the particles size is determine by 131 ± 28 nm for TAM-PLGA-OAMNP. The VSM analysis for TAM-PLGA-OAMNP showed no hysteresis loop indicating superparamagnetic characteristic. This projects also presents a discussion on the optimum condition for colloid stability for TAM-PLGA-OAMNPs based on the aggregation and sedimentation. Finally, TAM released behavior is studied. TAM-PLGA-OAMNPs followed a biphasic phase released. Pharmaceutical technology Drugs - Coatings 2017-05 Thesis http://psasir.upm.edu.my/id/eprint/69485/ http://psasir.upm.edu.my/id/eprint/69485/1/ITMA%202018%202%20-%20IR.pdf text en public masters Universiti Putra Malaysia Pharmaceutical technology Drugs - Coatings
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Pharmaceutical technology Drugs - Coatings
spellingShingle	Pharmaceutical technology Drugs - Coatings Albert, Emmellie Laura Encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle
description	Cancer chemotherapy drugs are not specific on their metabolic pathways to the cancer cell. Therefore, there is a need to overcome this disadvantages by applying targeted drug delivery using composite nanoparticles. Similarly, tamoxifen citrate (TAM) also suffer from this disadvantages. TAM is a drug used for breast cancer treatment. So, current investigations are proposing the usage of magnetite nanoparticles (MNP) as an anti-cancer drug carrier because of its biocompatibility, ultrafine size, and its superparamagnetic nature. In this study, poly (d,l-lactice-co-glycolide acid) (PLGA) were used to encapsulated both MNP and TAM to form a multifunctional nanoparticle which have both the superparamagnetic properties of MNP and therapeutic ability of TAM. MNP were synthesized via the co-precipitation method. Then, it was coated with oleic acid (OA) to reduce the aggregation and it was abbreviated as OAMNP. Formation of functionalized OAMNPs with TAM using PLGA (TAM-PLGA-OAMNP) was obtained by oil in water emulsion evaporation technique. The XRD pattern showed that crystalline phase of the MNP is inverse spinel cubic of Fe3O4. After modification, FTIR spectra revealed that the TAM were successfully encapsulated into the PLGA matrixes. By using TEM, the particles size is determine by 131 ± 28 nm for TAM-PLGA-OAMNP. The VSM analysis for TAM-PLGA-OAMNP showed no hysteresis loop indicating superparamagnetic characteristic. This projects also presents a discussion on the optimum condition for colloid stability for TAM-PLGA-OAMNPs based on the aggregation and sedimentation. Finally, TAM released behavior is studied. TAM-PLGA-OAMNPs followed a biphasic phase released.
format	Thesis
qualification_level	Master's degree
author	Albert, Emmellie Laura
author_facet	Albert, Emmellie Laura
author_sort	Albert, Emmellie Laura
title	Encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle
title_short	Encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle
title_full	Encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle
title_fullStr	Encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle
title_full_unstemmed	Encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle
title_sort	encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle
granting_institution	Universiti Putra Malaysia
publishDate	2017
url	http://psasir.upm.edu.my/id/eprint/69485/1/ITMA%202018%202%20-%20IR.pdf
_version_	1747812706381987840

Encapsulation of tamoxifen citrate conjugated with magnetite nanoparticle

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