Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy
Huperzia carinata and Huperzia nummolarifolia were chosen to be studied along with Hymenophyllum javanicum due to their relation in their phylogeny. These plants have been used traditionally for the treatment of contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate...
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| Format: | Thesis |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/69739/1/IB%202016%2027%20IR.pdf |
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| Summary: | Huperzia carinata and Huperzia nummolarifolia were chosen to be studied along
with Hymenophyllum javanicum due to their relation in their phylogeny. These
plants have been used traditionally for the treatment of contusions, strains, swellings,
schizophrenia, myasthenia gravis and organophosphate poisoning. The purpose of
this study is to isolate and purify the chemical constituents for these species and
elucidate the structures of the compounds isolated. The isolation procedures were
carried out by using a few separation methods such as column chromatography,
Sephadex and SPE. As a result, four compounds have been isolated from both
Huperzia species. They are 14β,21α-dihydroxyserrat-3β-yl acetate (S4), 14β,21β-
dihydroxyserrat-3β-yl acetate (S6), serratenediol (N2211-1-4) and 14β,21β-
trihydroxyserrat-3β-yl-p-dihydrocaffeate (E377). Whereas, four compounds have
been isolated from Hymenophyllum javanicum which are, Hymenoside W (KS-5),
[6-(3,4-dihydroxy-2-methylenebutoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-
yl)methyl-2-(3,4 dihydroxyphenyl)acetate] (KS-10-2) [6-(3,4-dihydroxy-2-
methylenebutoxy)-2-{[2-(3,4-dihydroxyphenyl)acetoxy]methyl}-4,5-dihydroxytetrahydro-
2H-pyran-3-yl-2-phenylacetate] (KS-8-10-4) and [6-(3,4-dihydroxy-2-
methylenebutoxy)-5-hydroxy-2-{(2-phenylacetoxy)methyl}tetrahydro-2H-pyran-
3,4-diyl-bis{2-(3,4-dihydroxyphenyl)acetate}] (KS-8-10-6). The structures of
isolated compounds were identified based on spectroscopic data including 1D and
2D NMR and comparison with the literature. |
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