Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy

Huperzia carinata and Huperzia nummolarifolia were chosen to be studied along with Hymenophyllum javanicum due to their relation in their phylogeny. These plants have been used traditionally for the treatment of contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate...

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Main Author:	Mohd Rani, Hazwani
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Ferns Lycopodiaceae
Online Access:	http://psasir.upm.edu.my/id/eprint/69739/1/IB%202016%2027%20IR.pdf
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id	my-upm-ir.69739
record_format	uketd_dc
spelling	my-upm-ir.697392019-10-29T06:27:18Z Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy 2015-11 Mohd Rani, Hazwani Huperzia carinata and Huperzia nummolarifolia were chosen to be studied along with Hymenophyllum javanicum due to their relation in their phylogeny. These plants have been used traditionally for the treatment of contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. The purpose of this study is to isolate and purify the chemical constituents for these species and elucidate the structures of the compounds isolated. The isolation procedures were carried out by using a few separation methods such as column chromatography, Sephadex and SPE. As a result, four compounds have been isolated from both Huperzia species. They are 14β,21α-dihydroxyserrat-3β-yl acetate (S4), 14β,21β- dihydroxyserrat-3β-yl acetate (S6), serratenediol (N2211-1-4) and 14β,21β- trihydroxyserrat-3β-yl-p-dihydrocaffeate (E377). Whereas, four compounds have been isolated from Hymenophyllum javanicum which are, Hymenoside W (KS-5), [6-(3,4-dihydroxy-2-methylenebutoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2- yl)methyl-2-(3,4 dihydroxyphenyl)acetate] (KS-10-2) [6-(3,4-dihydroxy-2- methylenebutoxy)-2-{[2-(3,4-dihydroxyphenyl)acetoxy]methyl}-4,5-dihydroxytetrahydro- 2H-pyran-3-yl-2-phenylacetate] (KS-8-10-4) and [6-(3,4-dihydroxy-2- methylenebutoxy)-5-hydroxy-2-{(2-phenylacetoxy)methyl}tetrahydro-2H-pyran- 3,4-diyl-bis{2-(3,4-dihydroxyphenyl)acetate}] (KS-8-10-6). The structures of isolated compounds were identified based on spectroscopic data including 1D and 2D NMR and comparison with the literature. Ferns Lycopodiaceae 2015-11 Thesis http://psasir.upm.edu.my/id/eprint/69739/ http://psasir.upm.edu.my/id/eprint/69739/1/IB%202016%2027%20IR.pdf text en public masters Universiti Putra Malaysia Ferns Lycopodiaceae
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Ferns Lycopodiaceae
spellingShingle	Ferns Lycopodiaceae Mohd Rani, Hazwani Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy
description	Huperzia carinata and Huperzia nummolarifolia were chosen to be studied along with Hymenophyllum javanicum due to their relation in their phylogeny. These plants have been used traditionally for the treatment of contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. The purpose of this study is to isolate and purify the chemical constituents for these species and elucidate the structures of the compounds isolated. The isolation procedures were carried out by using a few separation methods such as column chromatography, Sephadex and SPE. As a result, four compounds have been isolated from both Huperzia species. They are 14β,21α-dihydroxyserrat-3β-yl acetate (S4), 14β,21β- dihydroxyserrat-3β-yl acetate (S6), serratenediol (N2211-1-4) and 14β,21β- trihydroxyserrat-3β-yl-p-dihydrocaffeate (E377). Whereas, four compounds have been isolated from Hymenophyllum javanicum which are, Hymenoside W (KS-5), [6-(3,4-dihydroxy-2-methylenebutoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2- yl)methyl-2-(3,4 dihydroxyphenyl)acetate] (KS-10-2) [6-(3,4-dihydroxy-2- methylenebutoxy)-2-{[2-(3,4-dihydroxyphenyl)acetoxy]methyl}-4,5-dihydroxytetrahydro- 2H-pyran-3-yl-2-phenylacetate] (KS-8-10-4) and [6-(3,4-dihydroxy-2- methylenebutoxy)-5-hydroxy-2-{(2-phenylacetoxy)methyl}tetrahydro-2H-pyran- 3,4-diyl-bis{2-(3,4-dihydroxyphenyl)acetate}] (KS-8-10-6). The structures of isolated compounds were identified based on spectroscopic data including 1D and 2D NMR and comparison with the literature.
format	Thesis
qualification_level	Master's degree
author	Mohd Rani, Hazwani
author_facet	Mohd Rani, Hazwani
author_sort	Mohd Rani, Hazwani
title	Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy
title_short	Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy
title_full	Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy
title_fullStr	Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy
title_full_unstemmed	Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy
title_sort	phytochemical constituents of hymenophyllum javanicum spreng., huperzia carinata (desv. ex poir.) trevis and huperzia nummolarifolia (blume) jermy
granting_institution	Universiti Putra Malaysia
publishDate	2015
url	http://psasir.upm.edu.my/id/eprint/69739/1/IB%202016%2027%20IR.pdf
_version_	1747812722864553984

Phytochemical constituents of Hymenophyllum javanicum spreng., Huperzia carinata (Desv. ex Poir.) Trevis and Huperzia nummolarifolia (Blume) Jermy

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