Preparations of Betulinic Acid Derivatives
Betulinic acid, 3~hydroxy-lup20(29)-ene-28-oic acid is a pentacyclic triterpene. Esterification reactions of betulinic acid were investigated. Betulinic acid esters such as 3-0-succinyl-betulinic acid, 3-0-(2',2'-dimethylsucciny1)-betulinic acid, 3-0-(3',3'-dimethylsucciny1)-b...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | أطروحة |
| اللغة: | English English |
| منشور في: |
2004
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://psasir.upm.edu.my/id/eprint/7080/1/FSAS_2004_5%28a%29.pdf |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| id |
my-upm-ir.7080 |
|---|---|
| record_format |
uketd_dc |
| spelling |
my-upm-ir.70802023-11-21T08:23:00Z Preparations of Betulinic Acid Derivatives 2004 Mohd Ali, Mohd Tajudin Betulinic acid, 3~hydroxy-lup20(29)-ene-28-oic acid is a pentacyclic triterpene. Esterification reactions of betulinic acid were investigated. Betulinic acid esters such as 3-0-succinyl-betulinic acid, 3-0-(2',2'-dimethylsucciny1)-betulinic acid, 3-0-(3',3'-dimethylsucciny1)-betulinic acid and 3-0-glutaryl-betulinic acid were prepared. Their structures were determined by spectroscopic methods. Optimization studies on the esterification reactions were carried out for betulinic acid with succinic anhydride and with 2',2'-dimethylsuccinic acid only. The effects of varying parameters such as the mole ratio, temperature, time course and mole of catalyst were investigated. Generally, the optimal conditions for preparing 3-0-succinyl-betulinic acid was obtained by mixing betulinic acid with succinic anhydride in a 1:8 ratio and refluxing in 0.124 mole of pyridine for 24 hours at a temperature of 115°C ; the optimal conditions for the preparation of 3-0-(2',2'-dimethylsucciny1)-betulinic acid was obtained by refluxing betulinic acid and Zf,2'-dimethylsuccinic acid in a 1:6 ratio with the presence of 0.124 mole of pyridine for 24 hours at a temperature of 85°C. The percentage conversions as detected by gas chromatography analysis were 53.5 and 56.2%, respectively. Betulin Esterification 2004 Thesis http://psasir.upm.edu.my/id/eprint/7080/ http://psasir.upm.edu.my/id/eprint/7080/1/FSAS_2004_5%28a%29.pdf text en public masters Universiti Putra Malaysia Betulin Esterification Faculty of Science And Environmental Studies Ahmad, Faujan English |
| institution |
Universiti Putra Malaysia |
| collection |
PSAS Institutional Repository |
| language |
English English |
| advisor |
Ahmad, Faujan |
| topic |
Betulin Esterification |
| spellingShingle |
Betulin Esterification Mohd Ali, Mohd Tajudin Preparations of Betulinic Acid Derivatives |
| description |
Betulinic acid, 3~hydroxy-lup20(29)-ene-28-oic acid is a pentacyclic triterpene.
Esterification reactions of betulinic acid were investigated. Betulinic acid
esters such as 3-0-succinyl-betulinic acid, 3-0-(2',2'-dimethylsucciny1)-betulinic
acid, 3-0-(3',3'-dimethylsucciny1)-betulinic acid and 3-0-glutaryl-betulinic acid
were prepared. Their structures were determined by spectroscopic methods.
Optimization studies on the esterification reactions were carried out for
betulinic acid with succinic anhydride and with 2',2'-dimethylsuccinic acid
only. The effects of varying parameters such as the mole ratio, temperature, time
course and mole of catalyst were investigated.
Generally, the optimal conditions for preparing 3-0-succinyl-betulinic acid was
obtained by mixing betulinic acid with succinic anhydride in a 1:8 ratio and
refluxing in 0.124 mole of pyridine for 24 hours at a temperature of 115°C ; the
optimal conditions for the preparation of 3-0-(2',2'-dimethylsucciny1)-betulinic acid was obtained by refluxing betulinic acid and Zf,2'-dimethylsuccinic acid in
a 1:6 ratio with the presence of 0.124 mole of pyridine for 24 hours at a
temperature of 85°C. The percentage conversions as detected by gas
chromatography analysis were 53.5 and 56.2%, respectively. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Mohd Ali, Mohd Tajudin |
| author_facet |
Mohd Ali, Mohd Tajudin |
| author_sort |
Mohd Ali, Mohd Tajudin |
| title |
Preparations of Betulinic Acid Derivatives |
| title_short |
Preparations of Betulinic Acid Derivatives |
| title_full |
Preparations of Betulinic Acid Derivatives |
| title_fullStr |
Preparations of Betulinic Acid Derivatives |
| title_full_unstemmed |
Preparations of Betulinic Acid Derivatives |
| title_sort |
preparations of betulinic acid derivatives |
| granting_institution |
Universiti Putra Malaysia |
| granting_department |
Faculty of Science And Environmental Studies |
| publishDate |
2004 |
| url |
http://psasir.upm.edu.my/id/eprint/7080/1/FSAS_2004_5%28a%29.pdf |
| _version_ |
1794018696388149248 |