Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths

This study aims to determine the occurrence of C. trachomatis infection across a multi-ethnic cohort of pregnant women who presented with preterm complications and stillbirths and to determine the risk factors for C. trachomatis infection. This study also detects C. trachomatis using nested PCR and...

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Main Author:	Sulaiman, Nurshahira
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Stillbirth - epidemiology - Malaysia
Online Access:	http://psasir.upm.edu.my/id/eprint/71500/1/FPSK%28M%29%202012%2044%20IR.pdf
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id	my-upm-ir.71500
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spelling	my-upm-ir.715002019-11-21T06:53:36Z Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths 2012-09 Sulaiman, Nurshahira This study aims to determine the occurrence of C. trachomatis infection across a multi-ethnic cohort of pregnant women who presented with preterm complications and stillbirths and to determine the risk factors for C. trachomatis infection. This study also detects C. trachomatis using nested PCR and PCR ELISA as the screening tools. A cross-sectional study on pregnant women less than 37 weeks of pregnancy who presented with preterm contractions, preterm premature rupture of membranes and stillbirths was carried out in two public hospitals in Southern Selangor, Malaysia. A total of 106 endocervical swabs obtained were subjected to DNA amplification using Nested PCR (BioSewoom, Korea) and PCR-ELISA (Roche, USA) for C. trachomatis detection.Self-administered questionnaires were used to collect data on demographic and behavioural factors. In addition, C. trachomatis was detected in 43% of women with preterm complications and in 62% of women with stillbirths. Multiple logistic regression analysis indicated that mothers who were less than 25 years old of age (OR 2.731; 95% CI: 1.139, 6.549) and Chinese ethnicity (OR 17.799; 95% CI: 1.406, 225.387) were significant independent risk factors for chlamydial infection (p<0.05). High prevalence of C. trachomatis infection was observed among women with preterm complications and stillbirths. This study supports the essential need to screen pregnant women with preterm complications and stillbirths for infection with C. trachomatis using highly sensitive PCR ELISA. Thus, early intervention such as antibiotic therapy can be instituted at the earliest possible time with appropriate screening guidelines to reduce the adverse outcomes of C. trachomatis infection. Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Stillbirth - epidemiology - Malaysia 2012-09 Thesis http://psasir.upm.edu.my/id/eprint/71500/ http://psasir.upm.edu.my/id/eprint/71500/1/FPSK%28M%29%202012%2044%20IR.pdf text en public masters Universiti Putra Malaysia Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Stillbirth - epidemiology - Malaysia
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Stillbirth - epidemiology - Malaysia
spellingShingle	Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Stillbirth - epidemiology - Malaysia Sulaiman, Nurshahira Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
description	This study aims to determine the occurrence of C. trachomatis infection across a multi-ethnic cohort of pregnant women who presented with preterm complications and stillbirths and to determine the risk factors for C. trachomatis infection. This study also detects C. trachomatis using nested PCR and PCR ELISA as the screening tools. A cross-sectional study on pregnant women less than 37 weeks of pregnancy who presented with preterm contractions, preterm premature rupture of membranes and stillbirths was carried out in two public hospitals in Southern Selangor, Malaysia. A total of 106 endocervical swabs obtained were subjected to DNA amplification using Nested PCR (BioSewoom, Korea) and PCR-ELISA (Roche, USA) for C. trachomatis detection.Self-administered questionnaires were used to collect data on demographic and behavioural factors. In addition, C. trachomatis was detected in 43% of women with preterm complications and in 62% of women with stillbirths. Multiple logistic regression analysis indicated that mothers who were less than 25 years old of age (OR 2.731; 95% CI: 1.139, 6.549) and Chinese ethnicity (OR 17.799; 95% CI: 1.406, 225.387) were significant independent risk factors for chlamydial infection (p<0.05). High prevalence of C. trachomatis infection was observed among women with preterm complications and stillbirths. This study supports the essential need to screen pregnant women with preterm complications and stillbirths for infection with C. trachomatis using highly sensitive PCR ELISA. Thus, early intervention such as antibiotic therapy can be instituted at the earliest possible time with appropriate screening guidelines to reduce the adverse outcomes of C. trachomatis infection.
format	Thesis
qualification_level	Master's degree
author	Sulaiman, Nurshahira
author_facet	Sulaiman, Nurshahira
author_sort	Sulaiman, Nurshahira
title	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_short	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_full	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_fullStr	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_full_unstemmed	Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
title_sort	occurrence of chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths
granting_institution	Universiti Putra Malaysia
publishDate	2012
url	http://psasir.upm.edu.my/id/eprint/71500/1/FPSK%28M%29%202012%2044%20IR.pdf
_version_	1747813015279894528

Occurrence of Chlamydia trachomatis infection in pregnant women with preterm complications and stillbirths

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