Development of convenient quality control analysis method and improvement on the radiochemical yield using F-18-Labelled choline

Prostate cancer continues to be the most prevalent cancer in men in Malaysia. It is anticipated that the number of prostate cancer sufferers’ will increase in future. In the case of Positron Emission Tomography / Computed Tomography (PET/CT), clinicians cannot solely rely on F-18 Fluorodeoxyglucose...

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Main Author:	Hassan, Muhammad Hishar
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Radiochemistry Choline Quality Control
Online Access:	http://psasir.upm.edu.my/id/eprint/75302/1/FPSK%28M%29%202016%2027%20IR.pdf
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id	my-upm-ir.75302
record_format	uketd_dc
spelling	my-upm-ir.753022019-10-17T08:27:55Z Development of convenient quality control analysis method and improvement on the radiochemical yield using F-18-Labelled choline 2016-09 Hassan, Muhammad Hishar Prostate cancer continues to be the most prevalent cancer in men in Malaysia. It is anticipated that the number of prostate cancer sufferers’ will increase in future. In the case of Positron Emission Tomography / Computed Tomography (PET/CT), clinicians cannot solely rely on F-18 Fluorodeoxyglucose (F-18 FDG) as there were few studies demonstrated the use of F-18 FDG was pointless in prostate cancer imaging. Thus, this current study presents development of convenient quality control analysis method and improvement performed on the azeotropic drying of no-carrier-added (n.c.a.) F-18 Fluorine to increase the F-18 Fluorocholine (F-18 FCH) radiochemical yield. From these studies, a convenient, efficient and reliable method for quality control analysis of F-18 FCH was successfully developed and validated to comply all the release criteria even in a limited equipment set-up. As most of the equipment set-up in the quality control laboratory in the present study was meant for the routine quality control analysis of F-18 FDG, several parameters were changed in order to adapt to the F-18 FCH quality control method without affecting the routine quality control analysis of F-18 FDG. The synthesis of F-18 FCH was successfully performed on a commercial synthesis module, GE TracerLab MxFDG with fairly good radiochemical yields, between 5 to 15%, which decay is not corrected. Interestingly, the finding from this study shows the potential of improvement on the azeotropic drying condition of n.c.a F-18 Fluorine as a preferred technique to improve the radiochemical yield of F-18 FCH. Radiochemistry Choline Quality Control 2016-09 Thesis http://psasir.upm.edu.my/id/eprint/75302/ http://psasir.upm.edu.my/id/eprint/75302/1/FPSK%28M%29%202016%2027%20IR.pdf text en public masters Universiti Putra Malaysia Radiochemistry Choline Quality Control
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Radiochemistry Choline Quality Control
spellingShingle	Radiochemistry Choline Quality Control Hassan, Muhammad Hishar Development of convenient quality control analysis method and improvement on the radiochemical yield using F-18-Labelled choline
description	Prostate cancer continues to be the most prevalent cancer in men in Malaysia. It is anticipated that the number of prostate cancer sufferers’ will increase in future. In the case of Positron Emission Tomography / Computed Tomography (PET/CT), clinicians cannot solely rely on F-18 Fluorodeoxyglucose (F-18 FDG) as there were few studies demonstrated the use of F-18 FDG was pointless in prostate cancer imaging. Thus, this current study presents development of convenient quality control analysis method and improvement performed on the azeotropic drying of no-carrier-added (n.c.a.) F-18 Fluorine to increase the F-18 Fluorocholine (F-18 FCH) radiochemical yield. From these studies, a convenient, efficient and reliable method for quality control analysis of F-18 FCH was successfully developed and validated to comply all the release criteria even in a limited equipment set-up. As most of the equipment set-up in the quality control laboratory in the present study was meant for the routine quality control analysis of F-18 FDG, several parameters were changed in order to adapt to the F-18 FCH quality control method without affecting the routine quality control analysis of F-18 FDG. The synthesis of F-18 FCH was successfully performed on a commercial synthesis module, GE TracerLab MxFDG with fairly good radiochemical yields, between 5 to 15%, which decay is not corrected. Interestingly, the finding from this study shows the potential of improvement on the azeotropic drying condition of n.c.a F-18 Fluorine as a preferred technique to improve the radiochemical yield of F-18 FCH.
format	Thesis
qualification_level	Master's degree
author	Hassan, Muhammad Hishar
author_facet	Hassan, Muhammad Hishar
author_sort	Hassan, Muhammad Hishar
title	Development of convenient quality control analysis method and improvement on the radiochemical yield using F-18-Labelled choline
title_short	Development of convenient quality control analysis method and improvement on the radiochemical yield using F-18-Labelled choline
title_full	Development of convenient quality control analysis method and improvement on the radiochemical yield using F-18-Labelled choline
title_fullStr	Development of convenient quality control analysis method and improvement on the radiochemical yield using F-18-Labelled choline
title_full_unstemmed	Development of convenient quality control analysis method and improvement on the radiochemical yield using F-18-Labelled choline
title_sort	development of convenient quality control analysis method and improvement on the radiochemical yield using f-18-labelled choline
granting_institution	Universiti Putra Malaysia
publishDate	2016
url	http://psasir.upm.edu.my/id/eprint/75302/1/FPSK%28M%29%202016%2027%20IR.pdf
_version_	1747813026833104896

Development of convenient quality control analysis method and improvement on the radiochemical yield using F-18-Labelled choline

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