Association between insulin resistance and cancer among patients of the diagnostic Nuclear Imaging Center at UPM and Hospital Serdang

Insulin resistance (IR) is a major risk factor for Type 2 diabetes. Type 2 diabetes among other non-communicable diseases are major public health concerns with increased significance and prevalence. Cancer on the other hand was a leading cause of death worldwide in 2008. Studies have attributed the...

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Main Author:	Korie, Ezinne Oyidia
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Insulin resistance Neoplasms - Diagnosis Neoplasms - etiology
Online Access:	http://psasir.upm.edu.my/id/eprint/75303/1/FPSK%28M%29%202013%2043%20IR.pdf
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id	my-upm-ir.75303
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spelling	my-upm-ir.753032019-11-21T07:48:52Z Association between insulin resistance and cancer among patients of the diagnostic Nuclear Imaging Center at UPM and Hospital Serdang 2013-12 Korie, Ezinne Oyidia Insulin resistance (IR) is a major risk factor for Type 2 diabetes. Type 2 diabetes among other non-communicable diseases are major public health concerns with increased significance and prevalence. Cancer on the other hand was a leading cause of death worldwide in 2008. Studies have attributed the link between carcinogenesis and insulin resistance to hyperinsulinemia. The Hyperinsulinemia Theory proposes that high levels of insulin decreases the production of insulin growth factor 1 (IGF-1) binding proteins and hence increases the levels of free IGF-1. The bioactivity of free IGF-1 has been known to increase tumor turnover rate. The main objective of this study is to determine the association between insulin resistance and cancer among patients at the Diagnostic Nuclear Imaging in University Putra Malaysia and Hospital Serdang, Malaysia. This study hypothesized significant association between insulin resistance and cancer. This case-control study was carried out at the Diagnostic Nuclear Imaging Center at the Medical Faculty in UPM (Universiti Putra Malaysia) and the surgical ward of Hospital Serdang. Based on the sample size calculation, it involved a total sample size of 100 (age and sex matched 45 cases and 55 controls). Consecutive sampling was used for patient recruitment. Insulin resistance was determined by the Homeostasis Model assessment of Insulin resistance (HOMA-IR) which is a validated index of insulin resistance. It correlates strongly and inversely with the basic Insulin Sensitivity Clamp Index; derived from the hyperinsulinemic euglycemic clamp (r = -0.572, P<0.001) and also a more practical method of measuring insulin resistance in large epidemiological studies. HOMA-IR, metabolic parameters and anthropometric measurements were collected and determined in all subjects. From the results, using logistic regression, insulin resistance was independently associated with cancer (Adjusted OR= 12.25. 95% CI = 3.20, 46.83) There was also significant association between obesity and cancer (Adjusted OR=3.33, 95% CI = 1.08, 10.31). The presence of IR in cancer cases if researched further might have the ability to show insights on the role of insulin resistance on cancer in general and also cancer prevention and treatment. Insulin resistance Neoplasms - Diagnosis Neoplasms - etiology 2013-12 Thesis http://psasir.upm.edu.my/id/eprint/75303/ http://psasir.upm.edu.my/id/eprint/75303/1/FPSK%28M%29%202013%2043%20IR.pdf text en public masters Universiti Putra Malaysia Insulin resistance Neoplasms - Diagnosis Neoplasms - etiology
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Insulin resistance Neoplasms - Diagnosis Neoplasms - etiology
spellingShingle	Insulin resistance Neoplasms - Diagnosis Neoplasms - etiology Korie, Ezinne Oyidia Association between insulin resistance and cancer among patients of the diagnostic Nuclear Imaging Center at UPM and Hospital Serdang
description	Insulin resistance (IR) is a major risk factor for Type 2 diabetes. Type 2 diabetes among other non-communicable diseases are major public health concerns with increased significance and prevalence. Cancer on the other hand was a leading cause of death worldwide in 2008. Studies have attributed the link between carcinogenesis and insulin resistance to hyperinsulinemia. The Hyperinsulinemia Theory proposes that high levels of insulin decreases the production of insulin growth factor 1 (IGF-1) binding proteins and hence increases the levels of free IGF-1. The bioactivity of free IGF-1 has been known to increase tumor turnover rate. The main objective of this study is to determine the association between insulin resistance and cancer among patients at the Diagnostic Nuclear Imaging in University Putra Malaysia and Hospital Serdang, Malaysia. This study hypothesized significant association between insulin resistance and cancer. This case-control study was carried out at the Diagnostic Nuclear Imaging Center at the Medical Faculty in UPM (Universiti Putra Malaysia) and the surgical ward of Hospital Serdang. Based on the sample size calculation, it involved a total sample size of 100 (age and sex matched 45 cases and 55 controls). Consecutive sampling was used for patient recruitment. Insulin resistance was determined by the Homeostasis Model assessment of Insulin resistance (HOMA-IR) which is a validated index of insulin resistance. It correlates strongly and inversely with the basic Insulin Sensitivity Clamp Index; derived from the hyperinsulinemic euglycemic clamp (r = -0.572, P<0.001) and also a more practical method of measuring insulin resistance in large epidemiological studies. HOMA-IR, metabolic parameters and anthropometric measurements were collected and determined in all subjects. From the results, using logistic regression, insulin resistance was independently associated with cancer (Adjusted OR= 12.25. 95% CI = 3.20, 46.83) There was also significant association between obesity and cancer (Adjusted OR=3.33, 95% CI = 1.08, 10.31). The presence of IR in cancer cases if researched further might have the ability to show insights on the role of insulin resistance on cancer in general and also cancer prevention and treatment.
format	Thesis
qualification_level	Master's degree
author	Korie, Ezinne Oyidia
author_facet	Korie, Ezinne Oyidia
author_sort	Korie, Ezinne Oyidia
title	Association between insulin resistance and cancer among patients of the diagnostic Nuclear Imaging Center at UPM and Hospital Serdang
title_short	Association between insulin resistance and cancer among patients of the diagnostic Nuclear Imaging Center at UPM and Hospital Serdang
title_full	Association between insulin resistance and cancer among patients of the diagnostic Nuclear Imaging Center at UPM and Hospital Serdang
title_fullStr	Association between insulin resistance and cancer among patients of the diagnostic Nuclear Imaging Center at UPM and Hospital Serdang
title_full_unstemmed	Association between insulin resistance and cancer among patients of the diagnostic Nuclear Imaging Center at UPM and Hospital Serdang
title_sort	association between insulin resistance and cancer among patients of the diagnostic nuclear imaging center at upm and hospital serdang
granting_institution	Universiti Putra Malaysia
publishDate	2013
url	http://psasir.upm.edu.my/id/eprint/75303/1/FPSK%28M%29%202013%2043%20IR.pdf
_version_	1747813027074277376

Association between insulin resistance and cancer among patients of the diagnostic Nuclear Imaging Center at UPM and Hospital Serdang

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