Synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin

Eighteen tridentate Schiff bases derived from thiosemicarbazide were synthesized using various aldehydes and ketones via condensation reaction. Eighteen new mixedligand metal complexes were synthesized by reacting copper saccharinate with the appropriate Schiff bases in water-ethanol mixtures and ha...

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Main Author:	Mohd Mokhtaruddin, Nur Shuhada
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Saccharin Copper
Online Access:	http://psasir.upm.edu.my/id/eprint/75484/1/FS%202016%2024%20-%20IR.pdf
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id	my-upm-ir.75484
record_format	uketd_dc
spelling	my-upm-ir.754842019-10-18T08:10:49Z Synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin 2016-01 Mohd Mokhtaruddin, Nur Shuhada Eighteen tridentate Schiff bases derived from thiosemicarbazide were synthesized using various aldehydes and ketones via condensation reaction. Eighteen new mixedligand metal complexes were synthesized by reacting copper saccharinate with the appropriate Schiff bases in water-ethanol mixtures and have been characterized by elemental analysis and conductance, magnetic susceptibility, FTIR and electronic spectroscopic measurements. The complexes formed with general formula [Cu(sac)(NNS)]/[Cu(sac)(NNS)(H₂O)] or [Cu(sac)(ONS)]/[Cu(sac)(ONS)(H₂O)] where NNS and ONS are tridentate ligands. Magnetic and spectral evidence support a four or five-coordinate geometry for the complexes in which the Schiff bases coordinate to the Cu(II) ion as a uninegative charged tridentate ligand through the pyridine nitrogen or phenoxide oxygen atom, azomethine nitrogen atom and thiolate sulphur atom. The saccharinate anion coordinates as a unidentate N-donor ligand. The fifth coordination positions are occupied by the oxygen atom of the aqua ligand. The molar conductance results indicate that the metal complexes were non-electrolytes in DMSO solution. The cytotoxic activities of the complexes and the Schiff bases were evaluated against two breast cancer cell lines, MCF-7 (Estrogen Receptor Positive Human Breast Carcinoma Cells) and MDA-MB-231 (Estrogen Receptor Negative Human Breast Carcinoma Cells). Most of the complexes showed a higher potential compared than their ligands towards both cancer cell lines. The copper complexes were also deposited into copper oxide thin films by using Aerosol-Assisted Chemical Vapour Deposition technique and characterized by XRD and FESEM. The photocurrent activity of the copper oxide thin films was carried out but showed negative results. Saccharin Copper 2016-01 Thesis http://psasir.upm.edu.my/id/eprint/75484/ http://psasir.upm.edu.my/id/eprint/75484/1/FS%202016%2024%20-%20IR.pdf text en public masters Universiti Putra Malaysia Saccharin Copper
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Saccharin Copper
spellingShingle	Saccharin Copper Mohd Mokhtaruddin, Nur Shuhada Synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin
description	Eighteen tridentate Schiff bases derived from thiosemicarbazide were synthesized using various aldehydes and ketones via condensation reaction. Eighteen new mixedligand metal complexes were synthesized by reacting copper saccharinate with the appropriate Schiff bases in water-ethanol mixtures and have been characterized by elemental analysis and conductance, magnetic susceptibility, FTIR and electronic spectroscopic measurements. The complexes formed with general formula [Cu(sac)(NNS)]/[Cu(sac)(NNS)(H₂O)] or [Cu(sac)(ONS)]/[Cu(sac)(ONS)(H₂O)] where NNS and ONS are tridentate ligands. Magnetic and spectral evidence support a four or five-coordinate geometry for the complexes in which the Schiff bases coordinate to the Cu(II) ion as a uninegative charged tridentate ligand through the pyridine nitrogen or phenoxide oxygen atom, azomethine nitrogen atom and thiolate sulphur atom. The saccharinate anion coordinates as a unidentate N-donor ligand. The fifth coordination positions are occupied by the oxygen atom of the aqua ligand. The molar conductance results indicate that the metal complexes were non-electrolytes in DMSO solution. The cytotoxic activities of the complexes and the Schiff bases were evaluated against two breast cancer cell lines, MCF-7 (Estrogen Receptor Positive Human Breast Carcinoma Cells) and MDA-MB-231 (Estrogen Receptor Negative Human Breast Carcinoma Cells). Most of the complexes showed a higher potential compared than their ligands towards both cancer cell lines. The copper complexes were also deposited into copper oxide thin films by using Aerosol-Assisted Chemical Vapour Deposition technique and characterized by XRD and FESEM. The photocurrent activity of the copper oxide thin films was carried out but showed negative results.
format	Thesis
qualification_level	Master's degree
author	Mohd Mokhtaruddin, Nur Shuhada
author_facet	Mohd Mokhtaruddin, Nur Shuhada
author_sort	Mohd Mokhtaruddin, Nur Shuhada
title	Synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin
title_short	Synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin
title_full	Synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin
title_fullStr	Synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin
title_full_unstemmed	Synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin
title_sort	synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin
granting_institution	Universiti Putra Malaysia
publishDate	2016
url	http://psasir.upm.edu.my/id/eprint/75484/1/FS%202016%2024%20-%20IR.pdf
_version_	1747813057663336448

Synthesis, characterization and applications of mixed-ligand copper(ii) complexes containing saccharin

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