Feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy

The occurrences of heart disease in cats had increased with the availability of echocardiography. These patients are often presented with congestive heart failure, feline aortic thromboembolism and sudden death. In this study, the objectives were; 1) to determine the mortality rate and survivability...

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Main Author:	Xi, Jessie Bay Ji
Format:	Thesis
Language:	English
Published:	2018
Subjects:	Cats - Diseases Heart Diseases - veterinary
Online Access:	http://psasir.upm.edu.my/id/eprint/76312/1/FPV%202018%2038%20IR.pdf
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id	my-upm-ir.76312
record_format	uketd_dc
spelling	my-upm-ir.763122020-01-28T02:18:19Z Feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy 2018-07 Xi, Jessie Bay Ji The occurrences of heart disease in cats had increased with the availability of echocardiography. These patients are often presented with congestive heart failure, feline aortic thromboembolism and sudden death. In this study, the objectives were; 1) to determine the mortality rate and survivability of cats diagnosed with congestive heart failure and, 2) to correlate the clinical progressions and outcomes of cats diagnosed with congestive heart failure that were treated with pimobendan. Information on cats presented at the University Veterinary Hospital, Universiti Putra Malaysia that were diagnosed with cardiac diseases were collected and the cat owners were contacted for follow-ups on the cats’ heart condition. The modified New York Medical Associate classification was used to stage the cats’ heart condition. The mortality rate and survivability was determined using the Kaplan-Meier estimator. Cats that showed no improvement after treatment with diuretics-ACE inhibitor combination were recruited and treated with pimobendan for two months. The clinical efficacy of the drug was monitored based on observation of clinical signs, measurement of serum cardiac troponin concentrations, blood pressure monitoring, radiography, and echocardiography. Data obtained was analysed using paired T-test and One-way ANOVA to determine the effect of pimobendan pre- and post-treatment during the 2 months therapy. As a conclusion, the mortality rate determined was 26.7% and the there was no survival benefit for the cats with compliant owners (p > 0.05) despite the class of the feline cardiac patients grouped into. Pimobendan treatment was beneficial for cats diagnosed with dilated cardiomyopathy and restrictive cardiomyopathy. Administration of pimobendan in cats with hypertrophy cardiomyopathy has to be monitored closely. Cats - Diseases Heart Diseases - veterinary 2018-07 Thesis http://psasir.upm.edu.my/id/eprint/76312/ http://psasir.upm.edu.my/id/eprint/76312/1/FPV%202018%2038%20IR.pdf text en public masters Universiti Putra Malaysia Cats - Diseases Heart Diseases - veterinary
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Cats - Diseases Heart Diseases - veterinary
spellingShingle	Cats - Diseases Heart Diseases - veterinary Xi, Jessie Bay Ji Feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy
description	The occurrences of heart disease in cats had increased with the availability of echocardiography. These patients are often presented with congestive heart failure, feline aortic thromboembolism and sudden death. In this study, the objectives were; 1) to determine the mortality rate and survivability of cats diagnosed with congestive heart failure and, 2) to correlate the clinical progressions and outcomes of cats diagnosed with congestive heart failure that were treated with pimobendan. Information on cats presented at the University Veterinary Hospital, Universiti Putra Malaysia that were diagnosed with cardiac diseases were collected and the cat owners were contacted for follow-ups on the cats’ heart condition. The modified New York Medical Associate classification was used to stage the cats’ heart condition. The mortality rate and survivability was determined using the Kaplan-Meier estimator. Cats that showed no improvement after treatment with diuretics-ACE inhibitor combination were recruited and treated with pimobendan for two months. The clinical efficacy of the drug was monitored based on observation of clinical signs, measurement of serum cardiac troponin concentrations, blood pressure monitoring, radiography, and echocardiography. Data obtained was analysed using paired T-test and One-way ANOVA to determine the effect of pimobendan pre- and post-treatment during the 2 months therapy. As a conclusion, the mortality rate determined was 26.7% and the there was no survival benefit for the cats with compliant owners (p > 0.05) despite the class of the feline cardiac patients grouped into. Pimobendan treatment was beneficial for cats diagnosed with dilated cardiomyopathy and restrictive cardiomyopathy. Administration of pimobendan in cats with hypertrophy cardiomyopathy has to be monitored closely.
format	Thesis
qualification_level	Master's degree
author	Xi, Jessie Bay Ji
author_facet	Xi, Jessie Bay Ji
author_sort	Xi, Jessie Bay Ji
title	Feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy
title_short	Feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy
title_full	Feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy
title_fullStr	Feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy
title_full_unstemmed	Feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy
title_sort	feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy
granting_institution	Universiti Putra Malaysia
publishDate	2018
url	http://psasir.upm.edu.my/id/eprint/76312/1/FPV%202018%2038%20IR.pdf
_version_	1747813155066609664

Feline congestive heart failure : mortality rate and survivability and determination of clinical efficacy of pimobendan as alternative therapy

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