Mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria

Chronic kidney disease (CKD) is commonly diagnosed in cats; especially in geriatric patients. Early management of CKD patients is up most important in order to slow down the disease progression. Management of feline CKD includes controlling proteinuria, maintaining the level of serum creatinine, ino...

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Main Author:	Manoraj, Hemadevy
Format:	Thesis
Language:	English
Published:	2018
Subjects:	Cats - Diseases - Research Chronic renal failure
Online Access:	http://psasir.upm.edu.my/id/eprint/76321/1/FPV%202018%2034%20IR.pdf
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id	my-upm-ir.76321
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spelling	my-upm-ir.763212020-01-21T06:56:38Z Mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria 2018-07 Manoraj, Hemadevy Chronic kidney disease (CKD) is commonly diagnosed in cats; especially in geriatric patients. Early management of CKD patients is up most important in order to slow down the disease progression. Management of feline CKD includes controlling proteinuria, maintaining the level of serum creatinine, inorganic phosphate level, and hypertension (if present). Greater level of proteinuria has been associated with faster progression of the kidney disease in humans and similarly in dogs and cats. A study conducted proven that telmisartan can help to reduce the degree of proteinuria in feline CKD patients. Thus the objectives of this study were; 1) to determine the mortality rate and survivability of cats diagnosed with chronic kidney disease; and 2) to determine the effectiveness of telmisartan on controlling proteinuria, blood pressure and serum creatinine level in cats diagnosed with CKD. Feline cats patients from year January 2016 to December 2017 diagnosed with chronic kidney disease were reviewed and owners were contacted for follow-up of the patient condition. Based on the information obtained, each cat patient’s kidney condition were staged, the mortality rate and estimated survivability rate were calculated. Five client-owned cats (stable CKD patients with supportive subcutaneous fluid therapy and renal supplement) were recruited for treatment with telmisartan. Baseline serum creatinine level, arterial blood pressure measurement and urine protein to creatinine ratio (UP/C) were obtained and assessed again on Day-14, -30 and -60 of post telmisartan therapy. The data will be analyzed using One-way ANOVA to compare the effect of telmisartan on proteinuria, blood pressure and serum creatinine level. Results and Conclusions This study revealed the mortality rate of cats diagnosed with CKD from year 2016 to 2017 in UVH is 81.1%. We also found out that there is no significant association between owner compliance and survivability of CKD patients in this study. In this preliminary study, telmisartan shown beneficial effects in reducing proteinuria and systolic blood pressure in feline CKD patients. Cats - Diseases - Research Chronic renal failure 2018-07 Thesis http://psasir.upm.edu.my/id/eprint/76321/ http://psasir.upm.edu.my/id/eprint/76321/1/FPV%202018%2034%20IR.pdf text en public masters Universiti Putra Malaysia Cats - Diseases - Research Chronic renal failure
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
topic	Cats - Diseases - Research Chronic renal failure
spellingShingle	Cats - Diseases - Research Chronic renal failure Manoraj, Hemadevy Mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria
description	Chronic kidney disease (CKD) is commonly diagnosed in cats; especially in geriatric patients. Early management of CKD patients is up most important in order to slow down the disease progression. Management of feline CKD includes controlling proteinuria, maintaining the level of serum creatinine, inorganic phosphate level, and hypertension (if present). Greater level of proteinuria has been associated with faster progression of the kidney disease in humans and similarly in dogs and cats. A study conducted proven that telmisartan can help to reduce the degree of proteinuria in feline CKD patients. Thus the objectives of this study were; 1) to determine the mortality rate and survivability of cats diagnosed with chronic kidney disease; and 2) to determine the effectiveness of telmisartan on controlling proteinuria, blood pressure and serum creatinine level in cats diagnosed with CKD. Feline cats patients from year January 2016 to December 2017 diagnosed with chronic kidney disease were reviewed and owners were contacted for follow-up of the patient condition. Based on the information obtained, each cat patient’s kidney condition were staged, the mortality rate and estimated survivability rate were calculated. Five client-owned cats (stable CKD patients with supportive subcutaneous fluid therapy and renal supplement) were recruited for treatment with telmisartan. Baseline serum creatinine level, arterial blood pressure measurement and urine protein to creatinine ratio (UP/C) were obtained and assessed again on Day-14, -30 and -60 of post telmisartan therapy. The data will be analyzed using One-way ANOVA to compare the effect of telmisartan on proteinuria, blood pressure and serum creatinine level. Results and Conclusions This study revealed the mortality rate of cats diagnosed with CKD from year 2016 to 2017 in UVH is 81.1%. We also found out that there is no significant association between owner compliance and survivability of CKD patients in this study. In this preliminary study, telmisartan shown beneficial effects in reducing proteinuria and systolic blood pressure in feline CKD patients.
format	Thesis
qualification_level	Master's degree
author	Manoraj, Hemadevy
author_facet	Manoraj, Hemadevy
author_sort	Manoraj, Hemadevy
title	Mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria
title_short	Mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria
title_full	Mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria
title_fullStr	Mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria
title_full_unstemmed	Mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria
title_sort	mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria
granting_institution	Universiti Putra Malaysia
publishDate	2018
url	http://psasir.upm.edu.my/id/eprint/76321/1/FPV%202018%2034%20IR.pdf
_version_	1747813155572023296

Mortality rate and survivability of cats diagnosed with chronic kidney disease and the effectiveness of telmisartan in management of proteinuria

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