Clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease

Feline lower urinary tract disease (FLUTD) is an inflammatory condition involving the bladder and urethra of the cat. Although there are many possible causes of FLUTD, cats generally exhibit similar clinical signs of stranguria, dysuria, pollakiuria, and haematuria. Obstructive FLUTD is an emergency...

Full description

Saved in:

Bibliographic Details
Main Author:	Phoon, Melissa Hoi-Ee
Format:	Thesis
Language:	English
Published:	2014
Subjects:	Urinary tract infections Cats
Online Access:	http://psasir.upm.edu.my/id/eprint/77411/1/FPV%202014%203%20ir.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-upm-ir.77411
record_format	uketd_dc
spelling	my-upm-ir.774112022-01-28T01:48:28Z Clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease 2014-06 Phoon, Melissa Hoi-Ee Feline lower urinary tract disease (FLUTD) is an inflammatory condition involving the bladder and urethra of the cat. Although there are many possible causes of FLUTD, cats generally exhibit similar clinical signs of stranguria, dysuria, pollakiuria, and haematuria. Obstructive FLUTD is an emergency as it is potentially life-threatening and requires intensive monitoring during hospitalisation. Death most frequently occurs as a result of impaired renal function leading to failure of toxin removal and maintenance of adequate fluid and electrolyte balance in the body. The purpose of this prospective study was to determine assess the changes inelectrolytes, renal parameters, urinalysis, electrocardiogram, and the presence of bacteriuria in cats diagnosed with obstructive FLUTD in University Veterinary Hospital, Universiti Putra Malaysia (UVH-UPM) from January to April 2014.Twenty hospitalised male cats presented with obstructive FLUTD and incompressible urinary bladders were recruited. The breeds included Domestic shorthair (n=1 0), Siamese (n= 1) and Persians (n=8) with the mean age of 36 months. Laboratory results (specifically renal parameters, urinalysis, urine culture), systolic blood pressure and electrocardiogram changes were obtained pre- and post-catheterisation. White blood cells count, urea, creatinine, potassium, and inorganic phosphate were significantly higher in obstructive FLUTD group compared to healthy group. No cats were found hypotensive in this study. Common finding in urinalysis were haematuria, leucocytes, and proteinuria. Interestingly, majority of the urine (n=13/17, 76%) was found no crystaluria.Triple phosphate (n=3/17, 18%) was the most common crystal in urinalysis. Urine bacteria culture revealed that 57% of urine samples collected on the first day of admission had no growth (n=8114). Bacteriuria was evident in 79.6% (n=11/14) of urine samples collected by day 3 post-catheterisation. The most common bacteria cultured were Escherichia coli and Kleibsella pneumoniae. 81% (n=13116) were hyperkalaemic (serum potassium> 5.5mmoI/L). There was significant relationship between serum potassium level and changes on electrocardiography (r= 0.75, P(l-tailed) <0.001). Statistically, the serum potassium level was significantly related to ventricular heart rate (r=> 0.40, P=0.015). From this study, catheterisation related urinary tract infection was evident. Despite electrolyte derangement, these obstructive FLUTD cats were not affected with hypotension. Future prospective studies that with a larger sample size and duration that includes urine bacterial culture and antibiotic sensitivity test is recommended. Urinary tract infections Cats 2014-06 Thesis http://psasir.upm.edu.my/id/eprint/77411/ http://psasir.upm.edu.my/id/eprint/77411/1/FPV%202014%203%20ir.pdf text en public masters Universiti Putra Malaysia Urinary tract infections Cats Khor, Kuan Hua
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
advisor	Khor, Kuan Hua
topic	Urinary tract infections Cats
spellingShingle	Urinary tract infections Cats Phoon, Melissa Hoi-Ee Clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease
description	Feline lower urinary tract disease (FLUTD) is an inflammatory condition involving the bladder and urethra of the cat. Although there are many possible causes of FLUTD, cats generally exhibit similar clinical signs of stranguria, dysuria, pollakiuria, and haematuria. Obstructive FLUTD is an emergency as it is potentially life-threatening and requires intensive monitoring during hospitalisation. Death most frequently occurs as a result of impaired renal function leading to failure of toxin removal and maintenance of adequate fluid and electrolyte balance in the body. The purpose of this prospective study was to determine assess the changes inelectrolytes, renal parameters, urinalysis, electrocardiogram, and the presence of bacteriuria in cats diagnosed with obstructive FLUTD in University Veterinary Hospital, Universiti Putra Malaysia (UVH-UPM) from January to April 2014.Twenty hospitalised male cats presented with obstructive FLUTD and incompressible urinary bladders were recruited. The breeds included Domestic shorthair (n=1 0), Siamese (n= 1) and Persians (n=8) with the mean age of 36 months. Laboratory results (specifically renal parameters, urinalysis, urine culture), systolic blood pressure and electrocardiogram changes were obtained pre- and post-catheterisation. White blood cells count, urea, creatinine, potassium, and inorganic phosphate were significantly higher in obstructive FLUTD group compared to healthy group. No cats were found hypotensive in this study. Common finding in urinalysis were haematuria, leucocytes, and proteinuria. Interestingly, majority of the urine (n=13/17, 76%) was found no crystaluria.Triple phosphate (n=3/17, 18%) was the most common crystal in urinalysis. Urine bacteria culture revealed that 57% of urine samples collected on the first day of admission had no growth (n=8114). Bacteriuria was evident in 79.6% (n=11/14) of urine samples collected by day 3 post-catheterisation. The most common bacteria cultured were Escherichia coli and Kleibsella pneumoniae. 81% (n=13116) were hyperkalaemic (serum potassium> 5.5mmoI/L). There was significant relationship between serum potassium level and changes on electrocardiography (r= 0.75, P(l-tailed) <0.001). Statistically, the serum potassium level was significantly related to ventricular heart rate (r=> 0.40, P=0.015). From this study, catheterisation related urinary tract infection was evident. Despite electrolyte derangement, these obstructive FLUTD cats were not affected with hypotension. Future prospective studies that with a larger sample size and duration that includes urine bacterial culture and antibiotic sensitivity test is recommended.
format	Thesis
qualification_level	Master's degree
author	Phoon, Melissa Hoi-Ee
author_facet	Phoon, Melissa Hoi-Ee
author_sort	Phoon, Melissa Hoi-Ee
title	Clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease
title_short	Clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease
title_full	Clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease
title_fullStr	Clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease
title_full_unstemmed	Clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease
title_sort	clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease
granting_institution	Universiti Putra Malaysia
publishDate	2014
url	http://psasir.upm.edu.my/id/eprint/77411/1/FPV%202014%203%20ir.pdf
_version_	1747813222204833792

Clinicopathological changes and bacteriuria in pre- and post-relief of urethral obstruction in cats with lower urinary tract disease

Similar Items