Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes
Three series of dithiocarbazate Schiff bases derived from S-2- methylbenzyldithiocarbazate, S-3-methylbenzyldithiocarbazate and S-4- methylbenzyldithiocarbazate were synthesised using thiophene-2-carboxaldehyde, methyl-2-thienylketone, 3-methylthiophene-2-carboxaldehyde, and 5- methylthiophene-2...
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| 格式: | Thesis |
| 语言: | English |
| 出版: |
2016
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| 主题: | |
| 在线阅读: | http://psasir.upm.edu.my/id/eprint/79329/1/FS%202016%2079%20IR.pdf |
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| 总结: | Three series of dithiocarbazate Schiff bases derived from S-2-
methylbenzyldithiocarbazate, S-3-methylbenzyldithiocarbazate and S-4-
methylbenzyldithiocarbazate were synthesised using thiophene-2-carboxaldehyde,
methyl-2-thienylketone, 3-methylthiophene-2-carboxaldehyde, and 5-
methylthiophene-2-carboxaldehyde via condensation. The Schiff bases were then
complexed with respective metal salts to produce transition metal complexes. The
metal complexes formed are expected to have general formula of [M(NS)2],
[M(NS)2.H2O], [M(NS)2.2H2O],and [M(NS)(H2O)(OAc-)] where M = Cu2+, Ni2+,
dan Zn2+.These compounds were characterised by elemental analysis, molar
conductivity, magnetic susceptibility and various spectroscopy techniques including
Fourier-Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR), Mass
Spectroscopy (MS), UltraViolet/Visible (UV/Vis) and Inductively Coupled Plasma-
Atomic Emission Spectroscopy(ICP-AES) analyses. The elemental data obtained are
in good agreement with the proposed molecular formula of the Schiff bases and
metal complexes. The magnetic susceptibility measurements and spectral results
support the coordination geometry in which the Schiff bases behave as bidentate NS
donor ligand coordinating via azomethine nitrogen and thiolo sulphur atom. The
Schiff bases and metal complexes have been evaluated for their biological activities
against two bladder cancer cell lines, RT-112 (non invasive) and EJ-28 (invasive).
Only [Cu(S2T2C)(H2O)(OAc-)], [Cu(S2M2TK)2], [Cu(S4T2C)2], [Cu(S4MB5MT)2]
and[ Ni(S4M2TK)(H2O)(OAc-)] showed remarkable anticancer properties while the
other compounds were inactive against both bladder cancer cell lines. A series of
Schiff bases derived from S-4-methylbenzyldithiocarbazate were developed as self
assembled monolayers (SAMs) and were tested for the detection of Zn2+ ion in water.
All the Schiff base modified electrodes showed better response for the detection of
Zn2+ion compared with the conventional electrode, indium tin oxide. |
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