Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes

Three series of dithiocarbazate Schiff bases derived from S-2- methylbenzyldithiocarbazate, S-3-methylbenzyldithiocarbazate and S-4- methylbenzyldithiocarbazate were synthesised using thiophene-2-carboxaldehyde, methyl-2-thienylketone, 3-methylthiophene-2-carboxaldehyde, and 5- methylthiophene-2...

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Main Author:	Ramli, Syahirah
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Transition metals Electrochemical analysis
Online Access:	http://psasir.upm.edu.my/id/eprint/79329/1/FS%202016%2079%20IR.pdf
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id	my-upm-ir.79329
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spelling	my-upm-ir.793292020-07-07T03:20:56Z Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes 2016-11 Ramli, Syahirah Three series of dithiocarbazate Schiff bases derived from S-2- methylbenzyldithiocarbazate, S-3-methylbenzyldithiocarbazate and S-4- methylbenzyldithiocarbazate were synthesised using thiophene-2-carboxaldehyde, methyl-2-thienylketone, 3-methylthiophene-2-carboxaldehyde, and 5- methylthiophene-2-carboxaldehyde via condensation. The Schiff bases were then complexed with respective metal salts to produce transition metal complexes. The metal complexes formed are expected to have general formula of [M(NS)2], [M(NS)2.H2O], [M(NS)2.2H2O],and [M(NS)(H2O)(OAc-)] where M = Cu2+, Ni2+, dan Zn2+.These compounds were characterised by elemental analysis, molar conductivity, magnetic susceptibility and various spectroscopy techniques including Fourier-Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR), Mass Spectroscopy (MS), UltraViolet/Visible (UV/Vis) and Inductively Coupled Plasma- Atomic Emission Spectroscopy(ICP-AES) analyses. The elemental data obtained are in good agreement with the proposed molecular formula of the Schiff bases and metal complexes. The magnetic susceptibility measurements and spectral results support the coordination geometry in which the Schiff bases behave as bidentate NS donor ligand coordinating via azomethine nitrogen and thiolo sulphur atom. The Schiff bases and metal complexes have been evaluated for their biological activities against two bladder cancer cell lines, RT-112 (non invasive) and EJ-28 (invasive). Only [Cu(S2T2C)(H2O)(OAc-)], [Cu(S2M2TK)2], [Cu(S4T2C)2], [Cu(S4MB5MT)2] and[ Ni(S4M2TK)(H2O)(OAc-)] showed remarkable anticancer properties while the other compounds were inactive against both bladder cancer cell lines. A series of Schiff bases derived from S-4-methylbenzyldithiocarbazate were developed as self assembled monolayers (SAMs) and were tested for the detection of Zn2+ ion in water. All the Schiff base modified electrodes showed better response for the detection of Zn2+ion compared with the conventional electrode, indium tin oxide. Transition metals Electrochemical analysis 2016-11 Thesis http://psasir.upm.edu.my/id/eprint/79329/ http://psasir.upm.edu.my/id/eprint/79329/1/FS%202016%2079%20IR.pdf text en public masters Universiti Putra Malaysia Transition metals Electrochemical analysis Begum, Thahira
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
advisor	Begum, Thahira
topic	Transition metals Electrochemical analysis
spellingShingle	Transition metals Electrochemical analysis Ramli, Syahirah Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes
description	Three series of dithiocarbazate Schiff bases derived from S-2- methylbenzyldithiocarbazate, S-3-methylbenzyldithiocarbazate and S-4- methylbenzyldithiocarbazate were synthesised using thiophene-2-carboxaldehyde, methyl-2-thienylketone, 3-methylthiophene-2-carboxaldehyde, and 5- methylthiophene-2-carboxaldehyde via condensation. The Schiff bases were then complexed with respective metal salts to produce transition metal complexes. The metal complexes formed are expected to have general formula of [M(NS)2], [M(NS)2.H2O], [M(NS)2.2H2O],and [M(NS)(H2O)(OAc-)] where M = Cu2+, Ni2+, dan Zn2+.These compounds were characterised by elemental analysis, molar conductivity, magnetic susceptibility and various spectroscopy techniques including Fourier-Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR), Mass Spectroscopy (MS), UltraViolet/Visible (UV/Vis) and Inductively Coupled Plasma- Atomic Emission Spectroscopy(ICP-AES) analyses. The elemental data obtained are in good agreement with the proposed molecular formula of the Schiff bases and metal complexes. The magnetic susceptibility measurements and spectral results support the coordination geometry in which the Schiff bases behave as bidentate NS donor ligand coordinating via azomethine nitrogen and thiolo sulphur atom. The Schiff bases and metal complexes have been evaluated for their biological activities against two bladder cancer cell lines, RT-112 (non invasive) and EJ-28 (invasive). Only [Cu(S2T2C)(H2O)(OAc-)], [Cu(S2M2TK)2], [Cu(S4T2C)2], [Cu(S4MB5MT)2] and[ Ni(S4M2TK)(H2O)(OAc-)] showed remarkable anticancer properties while the other compounds were inactive against both bladder cancer cell lines. A series of Schiff bases derived from S-4-methylbenzyldithiocarbazate were developed as self assembled monolayers (SAMs) and were tested for the detection of Zn2+ ion in water. All the Schiff base modified electrodes showed better response for the detection of Zn2+ion compared with the conventional electrode, indium tin oxide.
format	Thesis
qualification_level	Master's degree
author	Ramli, Syahirah
author_facet	Ramli, Syahirah
author_sort	Ramli, Syahirah
title	Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes
title_short	Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes
title_full	Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes
title_fullStr	Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes
title_full_unstemmed	Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes
title_sort	synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate schiff bases and their metal (ni, cu,and zn) complexes
granting_institution	Universiti Putra Malaysia
publishDate	2016
url	http://psasir.upm.edu.my/id/eprint/79329/1/FS%202016%2079%20IR.pdf
_version_	1747813316552556544

Synthesis, electrochemical and cytotoxic studies of bidentate dithiocarbazate Schiff bases and their metal (Ni, Cu,and Zn) complexes

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