Cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial

Fish intake may be cardioprotective, with omega-3 fatty acid as the possible major contributing nutrient. However, intervention study determining the cardioprotective effects of omega-3 rich fish is scarce. It is unclear whether yellowstripe scad (YSS) as compared with salmon, both rich in omega-...

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Main Author:	Chang, Wei Lin
Format:	Thesis
Language:	English
Published:	2019
Subjects:	Cardiovascular Diseases
Online Access:	http://psasir.upm.edu.my/id/eprint/79352/1/FPSK%28m%29%202019%205%20ir.pdf
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id	my-upm-ir.79352
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spelling	my-upm-ir.793522022-01-12T02:20:28Z Cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial 2019-01 Chang, Wei Lin Fish intake may be cardioprotective, with omega-3 fatty acid as the possible major contributing nutrient. However, intervention study determining the cardioprotective effects of omega-3 rich fish is scarce. It is unclear whether yellowstripe scad (YSS) as compared with salmon, both rich in omega-3 fatty acids, have effects on cardiovascular disease (CVD) risk factors. The objective of this study was to compare the effects of YSS and salmon on selected CVD risk factors among healthy overweight adults. A randomized crossover trial with two diet periods was conducted among healthy overweight (with BMI 23.0-27.4 kg/m2) Malaysian adults aged 21-55 years. Steamed whole YSS fish or salmon fillet was given for eight weeks (3 days per week), retaining approximately 1000 mg eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) per day. Diets were switched after an 8-week washout period. Fasting blood samples were collected before and after each diet period. Biochemical changes in serum and plasma were analysed. About 98 subjects were screened for eligibility and 49 subjects were participated in the intervention (35% male and 65% female; mean age 29±7 years). Results showed that P-selectin and erythrocyte sedimentation rate (ESR) were significantly reduced from baseline following the consumption of YSS (-13.024% and - 14.76% respectively, p< .05). Conversely, salmon group had significant improvement on lipid profile [triglycerides (-15.09%), HDL-cholesterol (+3.85%), and VLDLcholesterol (-14.58%)] and inflammatory cytokines [IL-6 (-5.88%) and TNF-α (-2.19%)] (p< .05). Uric acid was increased significantly by salmon diet from 0.32±0.10 mmol/L to 0.35±0.09 mmol/L (p< .05). Greater favourable effects on triglycerides (0.09 mmol/L, 95% CI=0.06-0.22, p= .01), VLDL-cholesterol (0.04 mmol/L, 95% CI=0.03- 0.11, p= .01), and IL-6 (0.01 pg/ml, 95% CI=-0.04-0.07, p= .03) were noted in salmon group as compared with YSS. These outcomes demonstrated that short-term consumption of salmon showed more pronounced effect on lipid profile and inflammatory factors as compared with YSS. Nevertheless, the favourable changes on haematological factors exerted by YSS group might deserve same attention. The beneficial effects of YSS and salmon on selected cardiovascular risk factors were unlikely to be similar despite their comparable EPA+DHA content. Cardiovascular Diseases 2019-01 Thesis http://psasir.upm.edu.my/id/eprint/79352/ http://psasir.upm.edu.my/id/eprint/79352/1/FPSK%28m%29%202019%205%20ir.pdf text en public masters Universiti Putra Malaysia Cardiovascular Diseases Loh, Su Peng
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
advisor	Loh, Su Peng
topic	Cardiovascular Diseases
spellingShingle	Cardiovascular Diseases Chang, Wei Lin Cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial
description	Fish intake may be cardioprotective, with omega-3 fatty acid as the possible major contributing nutrient. However, intervention study determining the cardioprotective effects of omega-3 rich fish is scarce. It is unclear whether yellowstripe scad (YSS) as compared with salmon, both rich in omega-3 fatty acids, have effects on cardiovascular disease (CVD) risk factors. The objective of this study was to compare the effects of YSS and salmon on selected CVD risk factors among healthy overweight adults. A randomized crossover trial with two diet periods was conducted among healthy overweight (with BMI 23.0-27.4 kg/m2) Malaysian adults aged 21-55 years. Steamed whole YSS fish or salmon fillet was given for eight weeks (3 days per week), retaining approximately 1000 mg eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) per day. Diets were switched after an 8-week washout period. Fasting blood samples were collected before and after each diet period. Biochemical changes in serum and plasma were analysed. About 98 subjects were screened for eligibility and 49 subjects were participated in the intervention (35% male and 65% female; mean age 29±7 years). Results showed that P-selectin and erythrocyte sedimentation rate (ESR) were significantly reduced from baseline following the consumption of YSS (-13.024% and - 14.76% respectively, p< .05). Conversely, salmon group had significant improvement on lipid profile [triglycerides (-15.09%), HDL-cholesterol (+3.85%), and VLDLcholesterol (-14.58%)] and inflammatory cytokines [IL-6 (-5.88%) and TNF-α (-2.19%)] (p< .05). Uric acid was increased significantly by salmon diet from 0.32±0.10 mmol/L to 0.35±0.09 mmol/L (p< .05). Greater favourable effects on triglycerides (0.09 mmol/L, 95% CI=0.06-0.22, p= .01), VLDL-cholesterol (0.04 mmol/L, 95% CI=0.03- 0.11, p= .01), and IL-6 (0.01 pg/ml, 95% CI=-0.04-0.07, p= .03) were noted in salmon group as compared with YSS. These outcomes demonstrated that short-term consumption of salmon showed more pronounced effect on lipid profile and inflammatory factors as compared with YSS. Nevertheless, the favourable changes on haematological factors exerted by YSS group might deserve same attention. The beneficial effects of YSS and salmon on selected cardiovascular risk factors were unlikely to be similar despite their comparable EPA+DHA content.
format	Thesis
qualification_level	Master's degree
author	Chang, Wei Lin
author_facet	Chang, Wei Lin
author_sort	Chang, Wei Lin
title	Cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial
title_short	Cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial
title_full	Cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial
title_fullStr	Cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial
title_full_unstemmed	Cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial
title_sort	cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial
granting_institution	Universiti Putra Malaysia
publishDate	2019
url	http://psasir.upm.edu.my/id/eprint/79352/1/FPSK%28m%29%202019%205%20ir.pdf
_version_	1747813317793021952

Cardioprotective effects of yellowstripe scad compared to salmon among healthy overweight adults in a randomized crossover trial

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