Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae)

The species of Artocarpus altitis from the Moraceae family and Micromelum minutum from the Rutaceae family were phytochemically studied and screened for their biological activities. The first species, Artocarpus altitis (Parkinson) Fosberg was collected from Kelantan and Pahang. Micromelum Minutu...

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Main Author:	Mohamed Shamaun, Shireen Shaharina
Format:	Thesis
Language:	English English
Published:	2008
Subjects:	Breadfruit Rutaceae
Online Access:	http://psasir.upm.edu.my/id/eprint/8532/1/FS_2008_10_IR.pdf
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id	my-upm-ir.8532
record_format	uketd_dc
spelling	my-upm-ir.85322023-12-06T00:32:04Z Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae) 2008-08 Mohamed Shamaun, Shireen Shaharina The species of Artocarpus altitis from the Moraceae family and Micromelum minutum from the Rutaceae family were phytochemically studied and screened for their biological activities. The first species, Artocarpus altitis (Parkinson) Fosberg was collected from Kelantan and Pahang. Micromelum Minutum (G. Forst.) Wight & Am. was collected from Sepilok, Sabah. The crude extracts and isolated compounds were screened for antimicrobial, cytotoxic and antioxidant activities using disc diffusion method, 1, 2-Diphenyl-2-picrylhydrazyl (DPPH) and Microculture Tetrazolium Salt (MTT) assays respectively. The microbes used for antimicrobial tests were methicilin resistant Staphylococcus aureus (MRSA), Bacillus subtilis and Pseudomonas aeruginosa.Detail study on the bark of Artocarpus altilis afforded cycloartocarpin (51), artocarpin (52), morusin (53), cycloartobiloxanthone (54) and artoindonesianin V (55). Chemical investigation on the root of Artocarpus altilis have resulted in the isolation of two new flavonoids, hydroxyartocarpin (56) and artocarpinin (57). Urs-12-en-3β-ol (58) and 6- methyl-β-D-glucopyranose (60) were isolated from the leaves of Micromelum minutum along with a coumarin known as 8-hydroxyisocapnolactone-2', 3'-diol (59). The leaves crude extract of Micromelum minutum gave strong cytotoxic activity towards HL 60 cell line and exhibited free radical scavenging activity towards DPPH. However, no activity was observed in the crude extract of Artocarpus altilis. Breadfruit Rutaceae 2008-08 Thesis http://psasir.upm.edu.my/id/eprint/8532/ http://psasir.upm.edu.my/id/eprint/8532/1/FS_2008_10_IR.pdf text en public masters Universiti Putra Malaysia Breadfruit Rutaceae Faculty of Science Rahmani, Mawardi English
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English English
advisor	Rahmani, Mawardi
topic	Breadfruit Rutaceae
spellingShingle	Breadfruit Rutaceae Mohamed Shamaun, Shireen Shaharina Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae)
description	The species of Artocarpus altitis from the Moraceae family and Micromelum minutum from the Rutaceae family were phytochemically studied and screened for their biological activities. The first species, Artocarpus altitis (Parkinson) Fosberg was collected from Kelantan and Pahang. Micromelum Minutum (G. Forst.) Wight & Am. was collected from Sepilok, Sabah. The crude extracts and isolated compounds were screened for antimicrobial, cytotoxic and antioxidant activities using disc diffusion method, 1, 2-Diphenyl-2-picrylhydrazyl (DPPH) and Microculture Tetrazolium Salt (MTT) assays respectively. The microbes used for antimicrobial tests were methicilin resistant Staphylococcus aureus (MRSA), Bacillus subtilis and Pseudomonas aeruginosa.Detail study on the bark of Artocarpus altilis afforded cycloartocarpin (51), artocarpin (52), morusin (53), cycloartobiloxanthone (54) and artoindonesianin V (55). Chemical investigation on the root of Artocarpus altilis have resulted in the isolation of two new flavonoids, hydroxyartocarpin (56) and artocarpinin (57). Urs-12-en-3β-ol (58) and 6- methyl-β-D-glucopyranose (60) were isolated from the leaves of Micromelum minutum along with a coumarin known as 8-hydroxyisocapnolactone-2', 3'-diol (59). The leaves crude extract of Micromelum minutum gave strong cytotoxic activity towards HL 60 cell line and exhibited free radical scavenging activity towards DPPH. However, no activity was observed in the crude extract of Artocarpus altilis.
format	Thesis
qualification_level	Master's degree
author	Mohamed Shamaun, Shireen Shaharina
author_facet	Mohamed Shamaun, Shireen Shaharina
author_sort	Mohamed Shamaun, Shireen Shaharina
title	Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae)
title_short	Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae)
title_full	Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae)
title_fullStr	Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae)
title_full_unstemmed	Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae)
title_sort	chemical constituents and biological activity of artocarpus altilis (moraceae) and micromelum minutum (rutaceae)
granting_institution	Universiti Putra Malaysia
granting_department	Faculty of Science
publishDate	2008
url	http://psasir.upm.edu.my/id/eprint/8532/1/FS_2008_10_IR.pdf
_version_	1794018764086312960

Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae)

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