Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species
Chemical investigation on the leaves of Ophiorrhiza species, O. communis and O. tomentosa, has resulted in the isolation of two indole type alkaloids, harman and strictosidinic acid. Strictosidinic acid was isolated from the butanol extract of both Ophiorrhiza communis and O. tomentosa while har...
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| Format: | Thesis |
| Language: | English English |
| Published: |
1994
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/8583/1/FSAS_1994_1_A.pdf |
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| Summary: | Chemical investigation on the leaves of Ophiorrhiza species,
O. communis and O. tomentosa, has resulted in the isolation of two
indole type alkaloids, harman and strictosidinic acid.
Strictosidinic acid was isolated from the butanol extract of both
Ophiorrhiza communis and O. tomentosa while harman was isolated
from O. communis only. The structures of these alkaloids were
elucidated using modern spectroscopic techniques such as UV, IR,
NMR, MS and also by comparison with the literature.
A study on the constituents of Hedyotis verticil lata has
resulted in the isolation of kaempferitrin and Hv2 whereas from
Hedyotis herbacea, kaempferol-3-0-rutinoside, ursolic
acid, kaempferol-3-0-arabinopyranoside and quercetin galactoside
were isolated. These structures were determined using modern
spectroscopic techniques and also by comparison with the
literature. A bioassay was also carried out using brine shrimp and anti
bacterial tests on the pure and crude compounds. The brine shrimp
tests showed that some of the compounds were very toxic whereas
the anti-bacterial tests showed that some compounds have
anti-bacterial properties and certainly these compounds have
potential for further investigations for their medicinal and
practical uses. |
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