Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species

Chemical investigation on the leaves of Ophiorrhiza species, O. communis and O. tomentosa, has resulted in the isolation of two indole type alkaloids, harman and strictosidinic acid. Strictosidinic acid was isolated from the butanol extract of both Ophiorrhiza communis and O. tomentosa while har...

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Main Author:	Hamzah, Ahmad Sazali
Format:	Thesis
Language:	English English
Published:	1994
Subjects:	Chemical elements Ophiorrhiza Hedyotis
Online Access:	http://psasir.upm.edu.my/id/eprint/8583/1/FSAS_1994_1_A.pdf
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id	my-upm-ir.8583
record_format	uketd_dc
spelling	my-upm-ir.85832012-05-07T07:08:55Z Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species 1994 Hamzah, Ahmad Sazali Chemical investigation on the leaves of Ophiorrhiza species, O. communis and O. tomentosa, has resulted in the isolation of two indole type alkaloids, harman and strictosidinic acid. Strictosidinic acid was isolated from the butanol extract of both Ophiorrhiza communis and O. tomentosa while harman was isolated from O. communis only. The structures of these alkaloids were elucidated using modern spectroscopic techniques such as UV, IR, NMR, MS and also by comparison with the literature. A study on the constituents of Hedyotis verticil lata has resulted in the isolation of kaempferitrin and Hv2 whereas from Hedyotis herbacea, kaempferol-3-0-rutinoside, ursolic acid, kaempferol-3-0-arabinopyranoside and quercetin galactoside were isolated. These structures were determined using modern spectroscopic techniques and also by comparison with the literature. A bioassay was also carried out using brine shrimp and anti bacterial tests on the pure and crude compounds. The brine shrimp tests showed that some of the compounds were very toxic whereas the anti-bacterial tests showed that some compounds have anti-bacterial properties and certainly these compounds have potential for further investigations for their medicinal and practical uses. Chemical elements Ophiorrhiza Hedyotis 1994 Thesis http://psasir.upm.edu.my/id/eprint/8583/ http://psasir.upm.edu.my/id/eprint/8583/1/FSAS_1994_1_A.pdf application/pdf en public masters Universiti Pertanian Malaysia Chemical elements Ophiorrhiza Hedyotis Faculty of Environmental Studies English
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English English
topic	Chemical elements Ophiorrhiza Hedyotis
spellingShingle	Chemical elements Ophiorrhiza Hedyotis Hamzah, Ahmad Sazali Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species
description	Chemical investigation on the leaves of Ophiorrhiza species, O. communis and O. tomentosa, has resulted in the isolation of two indole type alkaloids, harman and strictosidinic acid. Strictosidinic acid was isolated from the butanol extract of both Ophiorrhiza communis and O. tomentosa while harman was isolated from O. communis only. The structures of these alkaloids were elucidated using modern spectroscopic techniques such as UV, IR, NMR, MS and also by comparison with the literature. A study on the constituents of Hedyotis verticil lata has resulted in the isolation of kaempferitrin and Hv2 whereas from Hedyotis herbacea, kaempferol-3-0-rutinoside, ursolic acid, kaempferol-3-0-arabinopyranoside and quercetin galactoside were isolated. These structures were determined using modern spectroscopic techniques and also by comparison with the literature. A bioassay was also carried out using brine shrimp and anti bacterial tests on the pure and crude compounds. The brine shrimp tests showed that some of the compounds were very toxic whereas the anti-bacterial tests showed that some compounds have anti-bacterial properties and certainly these compounds have potential for further investigations for their medicinal and practical uses.
format	Thesis
qualification_level	Master's degree
author	Hamzah, Ahmad Sazali
author_facet	Hamzah, Ahmad Sazali
author_sort	Hamzah, Ahmad Sazali
title	Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species
title_short	Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species
title_full	Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species
title_fullStr	Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species
title_full_unstemmed	Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species
title_sort	isolation, characterization and biological activities of chemical constituents of ophiorrhiza and hedyotis species
granting_institution	Universiti Pertanian Malaysia
granting_department	Faculty of Environmental Studies
publishDate	1994
url	http://psasir.upm.edu.my/id/eprint/8583/1/FSAS_1994_1_A.pdf
_version_	1747810831847915520

Isolation, Characterization and Biological Activities of Chemical Constituents of Ophiorrhiza and Hedyotis Species

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