Association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in Malaysia

Malaysia is one of the Asian countries with a high incidence of nasopharyngeal carcinoma (NPC) with age-specific incidence rate (ASIR) of 7.2 per 100,000 population. Nutritional factors as well as workplace and environmental exposures have been implicated as risk factors of NPC. This case-control...

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Main Author:	Ulaganathan, Vaidehi
Format:	Thesis
Language:	English
Published:	2018
Subjects:	Nasopharyngeal Neoplasms - diagnosis Nasopharyngeal Neoplasms - therapy
Online Access:	http://psasir.upm.edu.my/id/eprint/92302/1/FPSK%28p%29%202018%2011%20-%20IR.pdf
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spelling	my-upm-ir.923022022-05-12T03:32:20Z Association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in Malaysia 2018-01 Ulaganathan, Vaidehi Malaysia is one of the Asian countries with a high incidence of nasopharyngeal carcinoma (NPC) with age-specific incidence rate (ASIR) of 7.2 per 100,000 population. Nutritional factors as well as workplace and environmental exposures have been implicated as risk factors of NPC. This case-control study was conducted to determine the association between circulating nutritional markers, diet, lifestyle factors, workplace and environmental exposure with risk and survival of NPC in the search for markers to predict risk and prognosticate survival for this disease. A total of 300 histologically confirmed NPC cases and 300 matched (age, gender, ethnicity) cancer-free controls from two local hospitals were recruited from 2012 to 2016. An interviewer-administrated questionnaire was used to capture information on sociodemographic background, dietary intake, physical activity, smoking, alcohol consumption and workplace and environmental exposures. Anthropometry measurements were taken directly after interview. The fasting blood sample was collected by a trained and qualified paramedic from respective hospitals and analyzed using relevant analysis in the laboratory. Clinical characteristics were obtained from patients’ medical records. The overall survival of NPC was 63.7% with 79.3% complete remission. Vigorous physical activity (AOR = 1.58, 95% CI = 1.09, 2.31), ex-smoking habit (AOR (quitted ≤ 2 years) = 4.69, 95% CI = 1.63, 13.5) and alcohol consumption (AOR (once a week) = 3.10, 95% CI =1.22, 7.91) significantly increased the risk of NPC. A medium consumption of high-protein dietary pattern was protective against NPC risk (AOR (Q2 vs Q1) = 0.44, 95% CI = 0.25, 0.76), while a high consumption of high-salted and processed food dietary pattern increased the risk of NPC (AOR (Q4 vs. Q1) = 9.75, 95% CI = 4.66, 20.38). Consumption of high vegetables and fruits dietary pattern showed no association with risk of NPC. Workplace exposures to leather, cloth, textiles or carpet (AOR (≥ 5 days/week) = 12.03, 95% CI = 1.39, 104.4) and dust, smoke, fumes or gases (AOR (≥ 5 days/week) = 2.50, 95% CI = 1.54, 4.07) significantly increased the risk of NPC. Environmental exposure to disinfectants or biocides significantly increased the risk of NPC (AOR = 2.84, 95% CI =1.21, 6.68). Advanced NPC stage (AOR (Stage 4C) = 5.64, 95% CI =1.13, 28.2), treatment with chemotherapy alone (AOR = 5.58, 95% CI = 2.30, 13.50) and low serum leptin level (AOR (Q1 vs. Q4) = 9.61, 95% CI = 3.36, 27.47) significantly increased risk of NPC mortality. In conclusion, the generation of risk models in this study based on these factors would not only increase understanding of NPC aetiology, but could potentially contribute to planning and implementation of clinical and public health interventions. Nasopharyngeal Neoplasms - diagnosis Nasopharyngeal Neoplasms - therapy 2018-01 Thesis http://psasir.upm.edu.my/id/eprint/92302/ http://psasir.upm.edu.my/id/eprint/92302/1/FPSK%28p%29%202018%2011%20-%20IR.pdf text en public doctoral Universiti Putra Malaysia Nasopharyngeal Neoplasms - diagnosis Nasopharyngeal Neoplasms - therapy Lye, Munn Sann
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English
advisor	Lye, Munn Sann
topic	Nasopharyngeal Neoplasms - diagnosis Nasopharyngeal Neoplasms - therapy
spellingShingle	Nasopharyngeal Neoplasms - diagnosis Nasopharyngeal Neoplasms - therapy Ulaganathan, Vaidehi Association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in Malaysia
description	Malaysia is one of the Asian countries with a high incidence of nasopharyngeal carcinoma (NPC) with age-specific incidence rate (ASIR) of 7.2 per 100,000 population. Nutritional factors as well as workplace and environmental exposures have been implicated as risk factors of NPC. This case-control study was conducted to determine the association between circulating nutritional markers, diet, lifestyle factors, workplace and environmental exposure with risk and survival of NPC in the search for markers to predict risk and prognosticate survival for this disease. A total of 300 histologically confirmed NPC cases and 300 matched (age, gender, ethnicity) cancer-free controls from two local hospitals were recruited from 2012 to 2016. An interviewer-administrated questionnaire was used to capture information on sociodemographic background, dietary intake, physical activity, smoking, alcohol consumption and workplace and environmental exposures. Anthropometry measurements were taken directly after interview. The fasting blood sample was collected by a trained and qualified paramedic from respective hospitals and analyzed using relevant analysis in the laboratory. Clinical characteristics were obtained from patients’ medical records. The overall survival of NPC was 63.7% with 79.3% complete remission. Vigorous physical activity (AOR = 1.58, 95% CI = 1.09, 2.31), ex-smoking habit (AOR (quitted ≤ 2 years) = 4.69, 95% CI = 1.63, 13.5) and alcohol consumption (AOR (once a week) = 3.10, 95% CI =1.22, 7.91) significantly increased the risk of NPC. A medium consumption of high-protein dietary pattern was protective against NPC risk (AOR (Q2 vs Q1) = 0.44, 95% CI = 0.25, 0.76), while a high consumption of high-salted and processed food dietary pattern increased the risk of NPC (AOR (Q4 vs. Q1) = 9.75, 95% CI = 4.66, 20.38). Consumption of high vegetables and fruits dietary pattern showed no association with risk of NPC. Workplace exposures to leather, cloth, textiles or carpet (AOR (≥ 5 days/week) = 12.03, 95% CI = 1.39, 104.4) and dust, smoke, fumes or gases (AOR (≥ 5 days/week) = 2.50, 95% CI = 1.54, 4.07) significantly increased the risk of NPC. Environmental exposure to disinfectants or biocides significantly increased the risk of NPC (AOR = 2.84, 95% CI =1.21, 6.68). Advanced NPC stage (AOR (Stage 4C) = 5.64, 95% CI =1.13, 28.2), treatment with chemotherapy alone (AOR = 5.58, 95% CI = 2.30, 13.50) and low serum leptin level (AOR (Q1 vs. Q4) = 9.61, 95% CI = 3.36, 27.47) significantly increased risk of NPC mortality. In conclusion, the generation of risk models in this study based on these factors would not only increase understanding of NPC aetiology, but could potentially contribute to planning and implementation of clinical and public health interventions.
format	Thesis
qualification_level	Doctorate
author	Ulaganathan, Vaidehi
author_facet	Ulaganathan, Vaidehi
author_sort	Ulaganathan, Vaidehi
title	Association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in Malaysia
title_short	Association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in Malaysia
title_full	Association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in Malaysia
title_fullStr	Association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in Malaysia
title_full_unstemmed	Association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in Malaysia
title_sort	association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in malaysia
granting_institution	Universiti Putra Malaysia
publishDate	2018
url	http://psasir.upm.edu.my/id/eprint/92302/1/FPSK%28p%29%202018%2011%20-%20IR.pdf
_version_	1747813725395484672

Association of circulating nutritional markers, diets, lifestyle, workplace and environmental exposures with nasopharyngeal carcinoma in two public hospitals in Malaysia

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