Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae)

Investigations on the leaves and stem bark of Clausena excavata (Rutaceae) have resulted in the isolation of twelve compounds. The structures of these compounds were elucidated b y using spectroscopic techniques such as NMR, MS, IR and UV and also by comparison with previous reports. The stem ba...

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Main Author:	Peh, Tian Hai
Format:	Thesis
Language:	English English
Published:	2001
Subjects:	Rutaceae Chemical elements - Spectra
Online Access:	http://psasir.upm.edu.my/id/eprint/9295/1/FSAS_2001_31.pdf
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id	my-upm-ir.9295
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spelling	my-upm-ir.92952024-02-19T05:16:31Z Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae) 2001-01 Peh, Tian Hai Investigations on the leaves and stem bark of Clausena excavata (Rutaceae) have resulted in the isolation of twelve compounds. The structures of these compounds were elucidated b y using spectroscopic techniques such as NMR, MS, IR and UV and also by comparison with previous reports. The stem bark of C. excavata collected from Jabi, Kedah yielded two new carbazole alkaloids, 1,8-dihydroxy-3-fonnyl-4-prenylcarbazole and 3- carbomethoxy-2-hydroxy-7 -methoxycarbazole, three known carbazole alkaloids, c1ausine-H, cIausine-K and cIausine-B together with one coumarin, scopoletin, two hmonoids (cIausenarin and CEA 10), and one triterpene, stigmasterol. From the leaves of C. excavata, a known carbazole alkaloid, 3-formyl-2 ,7- dimethoxycarbazole together with l3-sitosterol and safrole were isolated. The essential oils were obtained by hydrodistillatio n using fresh leaves and analysed using GC-MS spectrometry. The main essential oil components from Clausena excavata (Jabi A) were safrole and a-terpinolene, while Jabi B gave safrole and terpinolene as major constituents. The essential oils from several species of Citrus of Malaysia have also been investigated. Citronellal and citronellol were the major components of C. hystrix. The major constituents of C. aurantifolia were limonene, (z)-citral and (e)-citral. The major components of the oils of C. sinens is were found to be linalool and b-elemene . Germacrene-D, elernol and b-eudesmol were the major constituents of the oil of C. microcarpa. The oil of C. maxima (Kedah) contained significant amounts of sabinene, y-terpinene and Rutaceae Chemical elements - Spectra 2001-01 Thesis http://psasir.upm.edu.my/id/eprint/9295/ http://psasir.upm.edu.my/id/eprint/9295/1/FSAS_2001_31.pdf text en public masters Universiti Putra Malaysia Rutaceae Chemical elements - Spectra Faculty of Science and Environmental Studies Yap, Taufiq Yun Hin English
institution	Universiti Putra Malaysia
collection	PSAS Institutional Repository
language	English English
advisor	Yap, Taufiq Yun Hin
topic	Rutaceae Chemical elements - Spectra
spellingShingle	Rutaceae Chemical elements - Spectra Peh, Tian Hai Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae)
description	Investigations on the leaves and stem bark of Clausena excavata (Rutaceae) have resulted in the isolation of twelve compounds. The structures of these compounds were elucidated b y using spectroscopic techniques such as NMR, MS, IR and UV and also by comparison with previous reports. The stem bark of C. excavata collected from Jabi, Kedah yielded two new carbazole alkaloids, 1,8-dihydroxy-3-fonnyl-4-prenylcarbazole and 3- carbomethoxy-2-hydroxy-7 -methoxycarbazole, three known carbazole alkaloids, c1ausine-H, cIausine-K and cIausine-B together with one coumarin, scopoletin, two hmonoids (cIausenarin and CEA 10), and one triterpene, stigmasterol. From the leaves of C. excavata, a known carbazole alkaloid, 3-formyl-2 ,7- dimethoxycarbazole together with l3-sitosterol and safrole were isolated. The essential oils were obtained by hydrodistillatio n using fresh leaves and analysed using GC-MS spectrometry. The main essential oil components from Clausena excavata (Jabi A) were safrole and a-terpinolene, while Jabi B gave safrole and terpinolene as major constituents. The essential oils from several species of Citrus of Malaysia have also been investigated. Citronellal and citronellol were the major components of C. hystrix. The major constituents of C. aurantifolia were limonene, (z)-citral and (e)-citral. The major components of the oils of C. sinens is were found to be linalool and b-elemene . Germacrene-D, elernol and b-eudesmol were the major constituents of the oil of C. microcarpa. The oil of C. maxima (Kedah) contained significant amounts of sabinene, y-terpinene and
format	Thesis
qualification_level	Master's degree
author	Peh, Tian Hai
author_facet	Peh, Tian Hai
author_sort	Peh, Tian Hai
title	Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae)
title_short	Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae)
title_full	Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae)
title_fullStr	Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae)
title_full_unstemmed	Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae)
title_sort	chemical constituents and biological activities of clausena excavata and some citrus species (rutaceae)
granting_institution	Universiti Putra Malaysia
granting_department	Faculty of Science and Environmental Studies
publishDate	2001
url	http://psasir.upm.edu.my/id/eprint/9295/1/FSAS_2001_31.pdf
_version_	1794018817779695616

Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae)

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