Studies on coordination chemistry and bioactivity of complexes of Ni(II) and Cu(II) containing some nitrogen-sulphur donor ligands

Several Schiff bases of S-benzyldithiocarbazate (SBDTC) and Smethyldithiocarbazate (SMDTC) have been synthesised. Complexes of NiCll) and Cu(IT) were prepared. These compounds were characterised by elemental analyses and various physico-chemical techniques. The Schiff bases and their metal comple...

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主要作者: Nagalingam, Saravanan
格式: Thesis
语言:English
English
出版: 2001
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在线阅读:http://psasir.upm.edu.my/id/eprint/9300/1/FSAS_2001_37_A.pdf
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总结:Several Schiff bases of S-benzyldithiocarbazate (SBDTC) and Smethyldithiocarbazate (SMDTC) have been synthesised. Complexes of NiCll) and Cu(IT) were prepared. These compounds were characterised by elemental analyses and various physico-chemical techniques. The Schiff bases and their metal complexes were tested to evaluate their cytotoxic, antimicrobial and antioxidant activities. Cytotoxic screening was carried out against the T-Iymphoblastic leukemic cells (CEM-SS) and colon cancer cells (HT-29). Antimicrobial screening was carried out against four bacteria and four fungi. The nickelCTI) complexes are four- and five- coordinated while the copper(TI) complex is five-coordinated.